Causation pyramid model

Causation Pyramid Model enters the Adult Cognitive Disease corpus through the work of Prashant Joshi (submission 107), and is indexed here as one of the concepts that submission puts to work.

The argument it belongs to

Prashant Joshi's submission is summarised in this corpus as:

AD results from the disruption of multiple interconnected homeostatic metabolic processes that can be systematically catalogued and structured. The author identifies 132 interacting factors organized into a navigable database structure with causation levels and connectivity axes to map the complex web of AD pathogenesis.

Where it sits

The submission scores against the framework's convergence nodes as: neuroimmune interface 4 · compensatory paradigm 3 · ApoE4 hub 3 · transcriptional / epigenetic 3 · endosomal nexus 2 · cytoskeletal collapse 2.

Its declared subject matter: systems-biology, multifactorial, database-model, homeostasis, metabolic-dysfunction, factor-network, literature-review.

Named by the same submission

3 other concepts enter the corpus through the same paper, so they cover adjacent ground: Factor classification and connectivity · Interconnected homeostatic disruption · Navigable database of AD factors.


Assembled from the corpus rather than written: the summary is quoted from the submission that named it; the node scores are read from its dossier. It has not yet been expanded into an article.

Source: kb/wiki/concepts/Causation pyramid model.md