Adult Cognitive DiseaseThe research corpus Monographs
124 companion films

Videos

Most papers in the corpus have a short film on the Adult Cognitive Disease channel. They are laid out here the way the wiki is — along the disease's own fifty-year timeline. Every thumbnail opens the film; the title opens the paper.

Watch the full channel on YouTube →

Start Here 6

The 50-Year Front — The Temporal Architecture of Alzheimer's
The Master Theory: Why All Roads Lead to the Same Failure
One Mechanism, Many Diseases (AD, PD, ALS, HD)

The Record 8

The Eight Stages
Disciplinary Silos in AD Research, 1950–2020
Fischer's Sidelining: A Biographical–Intellectual History
Fischer's Matrix: The Founder Axis Rediscovered
What If We'd Listened to Fischer?

Groundwork 26

The Fifty-Year Prescription
The Uncleared Signal
The Load-Bearing Lipid
The Wrong Half of the Molecule
The Fifth Surface
The Crowded Cleft
The Unthrown Switch
The Mitochondrion as Nexus
The Vascular Phasing (PhD Thesis)
Vascular Pathology as a Substrate Across Phases
The Genetic Architecture of Neurodegeneration (PhD)
The Narrow Gate Every Mitochondrial Protein Must Pass
Where the Lipid Disorder and the Energy Disorder Are One
The Lipid That Kills Neurons and Spares Tumours
The Genes That Protect — Phenocopy the Fortunate
Down Syndrome as the Disease Run in Fast-Forward
The Cell Biology of the Word 'Ageing'
The Reversible Layer — Erosion of the Cell's Memory
Why Exercise Prevents but Does Not Cure
When the Brain's Trophic Subsidy Is Withdrawn
The Glial Consortium and the Timeline of Collapse
Huang: Aβ as a Two-Faced Molecule
Beyond Hebb
Khachaturian: The Calcium Hypothesis & Systems Failure
Khachaturian: Calcium × Autolysosomal Acidification

Phase I — The Silent Brainstem Erosion 21

Where the First Tangle Is Lit
When the Gut Writes the First Depression
The Unpicked Seam
The Price and the Permission
The Standing Relay
The Coerulean Clock
The Single Cut
The Bioenergetic Thesis (Downloadable PDF)
The Tryptophan Partition (PhD Thesis)
NAD⁺ Restoration and CD38 Inhibition
Norepinephrine as a Two-Armed Pincer on Tau
The Enzyme That Cuts the Protective Lattice
The Gut Ecosystem as the Upstream Origin
The Failing Clock That Stops Defending the Brainstem
Sleep as the Shared Off-Line State of Every Collapse Axis
The Coerulean Interface — The Brainstem Origin of Alzheimer's
Anatomy of a Neurodegenerative Conduit — The Vagal Interface
The Locus Coeruleus & the Noradrenergic Prodrome

Phase II — The Hippocampal Bridgehead 21

The Inflammasome Versus the Reelin Brake
The Double Release
The Gardener's Restraint
The Unnetted Governor
The Locus Coeruleus as Phase Bridge
The Innate-Immune Sensor That Converts the Disease
When the Inflammasome Turns on the Matrix
One Sensor, Two Collapses — Which Arm Matters More?
Everything That Corrupts the Brain's Gardener, Ranked
The Microglion That Silences Tau's Phosphatase
The Immune Cells That Keep the Peace — Until They Don't
The Brain's Border Gate: Source, Sieve, and Sentinel
The Matrix as the Seventh Axis of Collapse
When the Attack Turns Proteolytic
Iron Chelation and GPX4 Stabilization
Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer's
Homeostatic Microglial Collapse
The Peripheral Arm of Homeostatic Collapse

Phase III — The Synaptic Disintegration 17

Can a Drug Copy the Luckiest Mutation?
The Brain's Architect and the Brake It Puts on Tau
The Three-Body Clasp at the Membrane
The Quiet Death
The Homeward Vector
The Losing Axon
The Switch and the Sieve
The Brake and the Blade
The Load-Bearing Neuron
The Licensing Tyrosine
The Contested Serine
Ramsden: When Oxidative Damage Reaches the Synapse
Small: The Endosomal Traffic Jam
Gouras: Intraneuronal Aβ and the Inside-Out Paradigm
Margolis: How Synapses Are Dismantled from Within
Shatz & Brott: Complement-Mediated Synaptic Pruning

The Convergence 10

How the Brain Washes Itself — and Why That Fails
Viral Reactivation Across Three Phases (PhD)
The Acid Test
The Clearance Collapse — One Machinery, Three Failures
How Plaques Actually Form: A Timeline
How Free Radicals Disable the Recycling System
How Viruses Sabotage Brain Cleanup
Can Vaccines Protect Against Dementia?
Many Causes, One Bottleneck
How to Fix the Broken Recycling System

The Synthesis 12

Terminal Collapse: Naming the Death
The Spectrum of Collapse
The Biomarker Cascade (PhD Thesis)
The Whole Architecture, Graded by Evidence
The Ketamine Paradox
The Homeostatic–Matrix–Synaptic (HMS) Collapse Model

The Frontier 2

Vaccines That May Prevent Dementia
The Therapeutic Landscape of Collapse

The Prize Entries 1

The Synapse That Could Not Switch Off

Important noticeThis is a research platform, not a medical site. Nothing here is medical advice, a diagnosis, or a treatment recommendation, and none of it has been reviewed by a regulator. The drugs, doses and trials discussed are research literature, not prescriptions. If dementia affects you or someone you care about, speak to a doctor.

Compiled from the knowledge base and the research corpus under the Organic Network Synthesis methodology · the research corpus of Adult Cognitive Disease · the seven monographs are here. 2026.

827 interlinked articles · 120 papers in full · 53 as typeset PDFs · 635 concepts · 7 convergence nodes · 5 temporal stages.

Discussion

Corrections and disagreements are welcome here, and citation corrections most of all. Posting needs a GitHub account. Please read Taking Part first — in particular, nothing here is medical advice.