Adult Cognitive DiseaseThe research corpus Monographs

Cytoskeletal Collapse Node

Actin and microtubule cytoskeleton attacked by multiple mechanisms, leading to dendritic spine loss and synaptic failure.

Converging Mechanisms

  • LIMK1 hyperactivation and cofilin inactivation (Ramsden: GSK3beta cascade)
  • Ephexin5-RhoA-ROCK-mediated actin-myosin contraction (Margolis)
  • Competitive synaptic plasticity dysregulation (Huang)
  • Complement-mediated dendritic spine destruction (Shatz/Brott)

Key Molecules

GSK3beta, LIMK1, cofilin, Ephexin5, RhoA, ROCK, PSD95

To be populated after CSC grading.

See Also

Papers converging on this axis

8
Causal and Common 6 concepts · 1 gene shared The Vascular Dimension 6 concepts shared From Synapse Loss to Neuronal Death in Alzheimer's Disease 5 concepts · 2 genes shared Convergent Synaptic Collapse (CSC) — Grading Reference 4 concepts · 4 genes shared The Architect's Understudy 5 concepts · 1 gene shared The Compressed Architecture 5 concepts · 1 gene shared The Trojan Neuroblast 5 concepts · 1 gene shared The Load-Bearing Neuron 4 concepts · 3 genes shared

Concepts on this axis

374
Abeta aggregation as necessary initiating eventAbeta as molecular prime moverAcyloxyacyl Hydrolase NeuroprotectionAD as a double prion disorderAD as accelerated aging of Abeta managementAD as accelerated normal agingAD as accumulation of insults exceeding homeostasisAD as clinical syndrome not diseaseAD as systemic disease not limited to brainAD caused by APP dysregulation not Abeta per seAdult hippocampal neurogenesis restorationAdult NeurogenesisAge-dependent feedback loops in neurodegenerationAge-dependent threshold modelAge-related immune dysfunction enables neurotropic virusesAging accelerators and deceleratorsAging as MechanismAging as root cause of ADAging-epigenetic-genetic interactionAI Disease Model DiscoveryAI Neurotherapeutic DiscoveryAI-based early diagnosisAluminum as primary environmental causeAluminum driving amyloid productionAmyloid and tau as secondary byproductsAmyloid and tau as secondary phenomenaAmyloid as age-related phenomenonAmyloid as antimicrobial defenseAmyloid as downstream secondaryAmyloid as secondary to synaptic dysfunctionAmyloid clearance as important as depositionAmyloid Clinical DisconnectAmyloid plaques as fibrotic scar tissue from BBB repairAmyloid structural diversity and toxicityAmyloid-beta as innate immune defenseAnti Ferroptotic BotanicalsAnti-prion therapeutics as novel drug strategyAntibody Target SpecificityAntimicrobial hypothesis of amyloidApoE isoform-heparin binding differences
Source: kb/wiki/convergence-nodes/cytoskeletal-collapse.md