Wiki · Index
Gene Index
Every gene the corpus names, re-scanned across the 848 published pages of this edition. Each entry carries its mention count and links straight to the papers and concept pages that discuss it — search a symbol or alias, or filter by cluster.
530
Genes
33,962
Mentions
848
Pages scanned
18
Clusters
APOE Amyloid & Tau core 496 docs
Matched on
apoe[234]? apo[- ]?E[234]? apolipoprotein E- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper291
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper153
- The Genetic Architecture of Neurodegeneration (PhD)paper109
- The Narrow Gate Every Mitochondrial Protein Must Passpaper101
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper87
- Mapping the Vascular onto the Genetic Dimension (PhD)paper80
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper77
- Choline, Phosphatidylcholine and APOE4 in Alzheimer's Diseasepaper76
- The Vascular Phasing (PhD Thesis)paper65
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper62
- The Genes That Protect — Phenocopy the Fortunatepaper58
- LRP1 and the Templated Spread of Misfolded Proteinpaper57
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper57
- Seth Margolis Revisitedpaper48
- Vascular Pathology as a Substrate Across Phasespaper47
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper45
- Tau Kindling in the Locus Coeruleuspaper44
- Cofilin Serine 3paper37
- Can a Drug Copy the Luckiest Mutation?paper34
- Estela Area-Gómez's MAM Theorypaper34
- The Brain's Architect and the Brake It Puts on Taupaper34
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper32
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper31
- The Losing Axonpaper30
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper29
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper29
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper26
- Reelin-ApoE receptor axis disruptionconcept22
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper21
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper21
- Restoring Autophagy in Neurodegenerationpaper21
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper21
- The Load-Bearing Neuronpaper21
- Gouraspaper20
- Margolispaper20
- ApoE4 structural vulnerabilityconcept18
- From Gut Ecology to the Failed Antidepressant Trialpaper18
- Peroxidized ApoE as proximate causeconcept18
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper18
- Microglial Restraint as Resiliencepaper17
- Todd Golde's Amyloid Cascade, Read for What It Addspaper17
- Immune-pathogen interaction modelconcept16
- Lipid peroxidation cascade at synapseconcept16
- Multi-cellular pathologyconcept16
- Neurovascular dysfunction as initiating eventconcept16
- Post-translational modification dysregulationconcept16
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper16
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper15
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper15
- PARP Inhibitors and the Locus Coeruleuspaper14
- APOE4 Pathogen Interactionconcept12
- Moosmann & Sohrepaper12
- TOMM40 Import Gateconcept12
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper11
- APOE4 Hubnode11
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper10
- Iron Chelation and GPX4 Stabilizationpaper10
- Lipid Transportconcept10
- Plaques Are Tombstones, Not Killerspaper10
- Rappoportpaper10
- Chronic Excitatory Insufficiencyconcept9
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper9
- The Lipid That Kills Neurons and Spares Tumourspaper9
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper9
- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper9
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper8
- Anne Eckert's Neuroendocrine Theory and the Withdrawal of Protection in the Ageing Brainpaper8
- Cholesterol Homeostasisconcept8
- Dietary Fatty Acid APOE4 Rescueconcept8
- Endolysosomal Dysfunctionconcept8
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper8
- Gene Environment Interactionconcept8
- Lipid Metabolismconcept8
- The Microglial Thesis (Downloadable PDF)paper8
- ApoE-centric unified modelconcept7
- APOE4 Endolysosomal Dysfunctionconcept7
- Endosomal Traffickingconcept7
- Excitatory–Inhibitory Balance in Alzheimer'spaper7
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper7
- Lipid Peroxidationconcept7
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper7
- Templated Tau Misfolding Across the Three Phasespaper7
- The Microglion That Silences Tau's Phosphatasepaper7
- Alzheimer's Disease — A Process in Timepaper6
- Brain Lipid Homeostasis Restorationconcept6
- Cholesterol Transportconcept6
- Chronic intracellular infection modelconcept6
- Convergent Autophagic Collapsepaper6
- Cortical Immature Neurons of Layer IIpaper6
- Dual Pathogen AD Pathogenesisconcept6
- Epigenetic Repressionconcept6
- Fischer's Sixth Stage and the Leptomeningeal Compartment It Never Enteredpaper6
- Infectious etiology of late-onset ADconcept6
- Matrix Sulfation Nodeconcept6
- Membrane Biologyconcept6
- Norepinephrine as a Two-Armed Pincer on Taupaper6
- Olfactory Route Neuroinvasionconcept6
- Olfactory vector hypothesisconcept6
- One Sugar Lattice, Three Jobspaper6
- Ordered Attrition and Resilience as the Two Human-Evidence Anchors of Alzheimer'spaper6
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper6
- Selective Tau Disruptionconcept6
- Smallpaper6
- Tau Scaffolding Interactionsconcept6
- Vesicular Traffickingconcept6
- Antibody Target Specificityconcept5
- ApoE isoform-heparin binding differencesconcept5
- Cholesterol deficiency driving AD pathologyconcept5
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper5
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper5
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper5
- Plaque IgG Sequestrationconcept5
- Scott Small's Retromer and Endosomal Theorypaper5
- Systemic to Central Immune Signalingconcept5
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper5
- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper5
- The Enzyme That Cuts the Protective Latticepaper5
- The Indifferent Neuronpaper5
- The Inflammasome Versus the Reelin Brakepaper5
- The Mitochondrion as Nexus (PhD Thesis)paper5
- Trauma Induced Viral Reactivationconcept5
- Vessel Associated Microglial Activationconcept5
- Viral Pathogenesisconcept5
- Abeta aggregation as necessary initiating eventconcept4
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper4
- Autophagy Dysfunctionconcept4
- Compensatory Homeostasisconcept4
- Endosomal Nexusnode4
- Environmental Toxicologyconcept4
- Excitatory Neurotransmissionconcept4
- Fischer's Eighth Stage as a Measurement of Rate Against Host Capacitypaper4
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper4
- Genetic evidence as gold standard for causalityconcept4
- Innate Immunityconcept4
- Long preclinical phase of AD pathologyconcept4
- Multifactorial modulation of disease trajectoryconcept4
- Pavel Kalvach's Case That Alzheimer's Is Not a Disease, Gradedpaper4
- PERK DLX1 Tau Axisconcept4
- Synaptic Physiologyconcept4
- Synaptic Plasticityconcept4
- Translational Regulation in Tauopathyconcept4
- Why Exercise Prevents but Does Not Curepaper4
- AD as accumulation of insults exceeding homeostasisconcept3
- Age-dependent feedback loops in neurodegenerationconcept3
- AI Neurotherapeutic Discoveryconcept3
- Amyloid Nucleationconcept3
- Antioxidant defense failureconcept3
- Autophagic Flux in Alzheimer's Diseasepaper3
- Autophagy-lysosomal failureconcept3
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper3
- Beth Stevens's Complement-Pruning Programpaper3
- BIN1 Autophagic Regulationconcept3
- Blood-based biomarker discoveryconcept3
- cGAS–STING in Alzheimer's Diseasepaper3
- Chronobiologic neuroprotection via melatoninconcept3
- Cognitive resilience as dynamic protective conceptconcept3
- Dietary Sodium Neurodegenerationconcept3
- Entropy as organizing principleconcept3
- Environmental and socioeconomic risk factorsconcept3
- Environmental toxicology of neurodegenerationconcept3
- Epigenetic regulation of AD genesconcept3
- ESCRT III Membrane Scissionconcept3
- Evolutionary framework for AD causationconcept3
- Evolutionary mismatch between genes and modern lifestyleconcept3
- Evolutionary mismatch hypothesisconcept3
- Extracellular Matrix Pathologyconcept3
- Familial vs sporadic ADconcept3
- Fischer's Staged Deposit, 1907–1912paper3
- GAG-driven AD pathogenesisconcept3
- Glycobiologyconcept3
- Gut-brain axis in neuroinflammationconcept3
- Health disparities in ADconcept3
- Infectious etiology of LOADconcept3
- Innate immunity failure in sporadic ADconcept3
- Inside Out Plaqueconcept3
- Intracellular Amyloidconcept3
- Lipid-driven neurodegenerationconcept3
- Lipid-glycan crosstalk in ADconcept3
- Liver-brain metabolic axisconcept3
- Lysosomal Acidificationconcept3
- Lysosomal Storage Diseaseconcept3
- Membrane lipid pathology in ADconcept3
- Mercury as primary AD causeconcept3
- Metabolic dysfunction in neurodegenerationconcept3
- Metal-protein interaction in diseaseconcept3
- Microglial Protein Biomarkersconcept3
- Modifiability of AD riskconcept3
- Morphological analysis methodologyconcept3
- Mosaic model of aging brainconcept3
- Multi-pathway AD pathophysiology reviewconcept3
- Multifactorial causal networkconcept3
- Multifactorial prevention through modifiable risk factorsconcept3
- Neurotransmitter disruption cascadeconcept3
- Non-optimal aging rather than normal aging processconcept3
- Onset vs Progressionconcept3
- Oxidative stress as unifying mechanismconcept3
- Phase IIpaper3
- Population-specific AD genetic signaturesconcept3
- Precision medicine for ADconcept3
- Production-clearance equilibriumconcept3
- Proteasome Tau Feedbackconcept3
- Proteoglycan role in amyloid formationconcept3
- Quality Control Collapseconcept3
- Risk factor convergenceconcept3
- SorLA Lipid ER Regulationconcept3
- The Brain's Border Gatepaper3
- The Calcium Hypothesis and the Systems Failure Model of Alzheimer's Diseasepaper3
- The Immunometabolic Nexus of Neurodegenerationpaper3
- The Locus Coeruleus as Phase Bridgepaper3
- The Matrix as the Seventh Axis of Collapsepaper3
- The Phase II → III Transitionpaper3
- The Strongest Case FOR the Amyloid Cascadepaper3
- Transcriptional Pause Releaseconcept3
- Unified theory of AD etiologyconcept3
- Vascular Amyloid Interactionconcept3
- Vascular dysfunction as earliest detectable changeconcept3
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper2
- Abeta as stress response markerconcept2
- Acyloxyacyl Hydrolase Neuroprotectionconcept2
- AD as accelerated aging of Abeta managementconcept2
- AD as clinical syndrome not diseaseconcept2
- AD caused by APP dysregulation not Abeta per seconcept2
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper2
- Adult Neurogenesisconcept2
- Age-dependent threshold modelconcept2
- Age-related immune dysfunction enables neurotropic virusesconcept2
- Aging accelerators and deceleratorsconcept2
- Aging as Mechanismconcept2
- Aging as root cause of ADconcept2
- Aging-epigenetic-genetic interactionconcept2
- AI Disease Model Discoveryconcept2
- AI-based early diagnosisconcept2
- Aluminum as primary environmental causeconcept2
- Aluminum driving amyloid productionconcept2
- Amyloid and tau as secondary byproductsconcept2
- Amyloid as antimicrobial defenseconcept2
- Amyloid as downstream secondaryconcept2
- Amyloid clearance as important as depositionconcept2
- Amyloid Clinical Disconnectconcept2
- Amyloid plaques as fibrotic scar tissue from BBB repairconcept2
- Amyloid-beta as innate immune defenseconcept2
- Anti Ferroptotic Botanicalsconcept2
- Antimicrobial Defenseconcept2
- Antimicrobial hypothesis of amyloidconcept2
- APP and tau pathology linked through transport disruptionconcept2
- APP as dependence receptorconcept2
- Astrocyte network management hypothesisconcept2
- Astrocyte-driven amyloid buildupconcept2
- Asymptomatic AD Phenotypingconcept2
- ATN biomarker classification systemconcept2
- ATP-chaperone-protein folding axisconcept2
- Autoimmune contribution via BBB compromiseconcept2
- Autoimmune Neurodegenerationconcept2
- Autophagic Collapseconcept2
- Autophagyconcept2
- Autophagy-amyloid couplingconcept2
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper2
- Axon initial segment as key disease locusconcept2
- Axonal atheroma hypothesisconcept2
- Axonal transport failure as unifying mechanismconcept2
- Bacterial exudate-driven neurodegenerationconcept2
- Barrier dysfunction pathologyconcept2
- BBB as gatekeeper failureconcept2
- BBB breakdown cascadeconcept2
- BBB degradation and pathogen invasionconcept2
- BBB-mediated vascular contributionconcept2
- BCG Immune Checkpoint Modulationconcept2
- Beta Alanine Neurotransmissionconcept2
- Bimodal brain (inference vs training)concept2
- Bioenergetic defects as early eventsconcept2
- Blood-based biomarker panels for preclinical detectionconcept2
- Blood-based lipid and protein module biomarkersconcept2
- Brain DNA blueprint is altered in AD neuronsconcept2
- Calcium-mediated tauopathyconcept2
- Cannabinoid Neuroprotectionconcept2
- Causation pyramid modelconcept2
- CDK3 Cell Cycle Toxicityconcept2
- Cellular Identityconcept2
- Cellular Vectorsconcept2
- Cholinergic network failure in ADconcept2
- Chronic intracellular pathogen-driven neurodegenerationconcept2
- Chronic neuroinflammation from infectionconcept2
- Chronic neuroinflammation from peripheryconcept2
- Circadian Immune Regulationconcept2
- Circadian regulation of glial functionconcept2
- Clearance failure vs. overproductionconcept2
- Collapse, Traced Cell Type by Cell Typepaper2
- Comparing Different Viral Triggerspaper2
- Computational AD Subtypingconcept2
- Convergent risk factor pathwaysconcept2
- Convergent signaling through Wnt-PCP-RhoA-ROCKconcept2
- Convergent Synaptic Collapseconcept2
- Cumulative axonal defect accumulationconcept2
- Cytoskeletal disorder as core pathologyconcept2
- Cytoskeletal Dynamicsconcept2
- Dark Genome Variationconcept2
- Double-hit mutation hypothesisconcept2
- Dynamic and region-independent disease mechanismsconcept2
- Eight factors of dementia frameworkconcept2
- Endosomal Lysosomal Networkconcept2
- Energy metabolism declineconcept2
- Environmental neurotoxicologyconcept2
- Environmental toxin contributionconcept2
- Epigenetic and genetic interplayconcept2
- Epigenetic Regulationconcept2
- Equilibrium at criticalityconcept2
- Existing HIV RT inhibitors as potential AD therapeuticsconcept2
- Exponential exposure-prevalence correlationconcept2
- Factor classification and connectivityconcept2
- Ferroptosisconcept2
- Ferroptosis in Neurodegenerationconcept2
- Functional model of neuron-glia interactionconcept2
- Gene dosage of APP directly causes pathogenesisconcept2
- Genetic shortcuts in FAD vs LOADconcept2
- GI-tract microbiome neurotoxicityconcept2
- Glial Biologyconcept2
- Glial contribution to neurodegenerationconcept2
- Glial inflammatory responseconcept2
- Glymphatic clearance failure amplifies pathologyconcept2
- Gut Brain Axisconcept2
- Gut Microbiome Lipid AD Axisconcept2
- Gut-brain axis in ADconcept2
- Human-germ interaction modelconcept2
- IDE-insulin-Abeta competitionconcept2
- Immunometabolismconcept2
- Immunosenescence as central aging mechanismconcept2
- Infection as co-factor in neurodegenerationconcept2
- Infectious etiology of ADconcept2
- Infectious origin of Alzheimer's diseaseconcept2
- Infectious-toxic-genetic synergyconcept2
- Inflamm-aging as disease driverconcept2
- Inflammaging integrates hallmarks of agingconcept2
- Information Theoretic Transcriptomicsconcept2
- Innate immune-mediated plaque formationconcept2
- Innate immunity network dysregulation in ADconcept2
- Integrated molecular-to-network perspectiveconcept2
- Integrative treatment across medical traditionsconcept2
- Interconnected homeostatic disruptionconcept2
- Intraneuronal amyloid accumulation as primary eventconcept2
- Iron Brain Paradoxconcept2
- Iron Dyshomeostasisconcept2
- Khachaturianpaper2
- Kinase Inhibitor Neuroprotectionconcept2
- Lifestyle and behavioral factorsconcept2
- Lifestyle as causal anchorconcept2
- Lifestyle intervention for cognitive reversalconcept2
- Lifestyle Microglial Modulationconcept2
- Limbic brain as circavital clock locusconcept2
- Lipid Dysregulationconcept2
- Lipid homeostasis as AD driverconcept2
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper2
- Locus coeruleus as ground zeroconcept2
- Membrane Biophysicsconcept2
- Membrane Lipid Dysregulationconcept2
- Memory building frameworkconcept2
- Memory construction disease modelconcept2
- Metabolic dysfunction as AD driverconcept2
- Metabolic-neurodegenerative disease connectionconcept2
- Microbial Pathogenesisconcept2
- Microbleeds as initiating vascular event in ADconcept2
- Microglial dysfunction as early eventconcept2
- Microglial Immunometabolismconcept2
- Microglial Lipid Regulationconcept2
- Microglial senescence as AD triggerconcept2
- Mitochondrial Dysfunctionconcept2
- Mitochondrial inheritance and ADconcept2
- Mitochondrial theory of agingconcept2
- Moving brain hypothesisconcept2
- MTHFR as catalytic pre-existing factorconcept2
- Multi-level heterogeneity of ADconcept2
- Multi-omics network approach to ADconcept2
- Multi-system medicine approach to ADconcept2
- Multidomain AD Interventionconcept2
- Multifactorial convergence modelconcept2
- Multifactorial etiologyconcept2
- Multifactorial risk accumulation modelconcept2
- Multipathology convergence theoryconcept2
- Multiple chronic stressorsconcept2
- Multiple converging factors in unified tauopathy frameworkconcept2
- NAD+ depletion drives neurodegenerationconcept2
- Navigable database of AD factorsconcept2
- Necrotic Cell Deathconcept2
- Need to understand normal APP functionconcept2
- Network-based combination therapyconcept2
- Neural Oscillationsconcept2
- Neuroendocrine shift at menopauseconcept2
- Neuroimmune Surveillanceconcept2
- Neuroinflammation as primary driver connecting all AD subsystemsconcept2
- Neuronal Excitabilityconcept2
- Neuronal lysis forming extracellular plaquesconcept2
- Neuronal network degradation as substrate of dementiaconcept2
- Neurovascular injury-repair cycle driving disease progressionconcept2
- Neurovascular unit as disease originconcept2
- NF-kB-miRNA inflammatory cascadeconcept2
- Nuclear pathology as early AD mechanismconcept2
- Omics Driven Profilingconcept2
- Omnigenic AD architectureconcept2
- Oral-brain infection axisconcept2
- Oxidative and nitrative stress as primary driverconcept2
- Oxidative Stressconcept2
- Oxygen deficiency as root causeconcept2
- P. gingivalis as keystone pathogenconcept2
- Peripheral Immunocyte Regulationconcept2
- Peripheral Lipid Biomarkersconcept2
- Peroxynitrite-mediated neurodegenerationconcept2
- Personalized multifactorial etiologyconcept2
- Phase IIIpaper2
- Polymicrobial brain infectionconcept2
- Polymicrobial causation of ADconcept2
- Precision genomics approachconcept2
- Precision Medicine ADconcept2
- Precision medicine protocolconcept2
- Preclinical Phase Activityconcept2
- Presymptomatic Lipidomic Signaturesconcept2
- Probabilistic multi-cause disease etiologyconcept2
- Programmed aging clock model of ADconcept2
- Proteostasis Collapseconcept2
- Proteostasis disruptionconcept2
- Psychosocial Risk Factorsconcept2
- Re-evaluating Tsai's 40 Hz Gamma Programpaper2
- Receptor-mediated amyloid internalizationconcept2
- Resilience as key to understanding AD clinical expressionconcept2
- Retrotransposon Activationconcept2
- Retroviral-like mechanisms drive disease propagationconcept2
- RNA-based diagnostics and therapeuticsconcept2
- Sex Dimorphic AD Mechanismsconcept2
- Sex Specific MiRNA Signaturesconcept2
- Sex-based hemoglobin differentialconcept2
- Sex-specific AD vulnerabilityconcept2
- Sex-specific disease mechanismsconcept2
- Signal Insufficiency Model (SIM)concept2
- Silica water as protective interventionconcept2
- Single Cell AD Signaturesconcept2
- Small ncRNA regulation of neurodegenerationconcept2
- Solomon Carter Fuller's 1911 Plaque Audit, Read Beside Oskar Fischer'spaper2
- Somatic Mosaicism in ADconcept2
- Somatic mutations as novel therapeutic targetsconcept2
- Somatic recombination creates pathogenic gene variantsconcept2
- SORL1 Lysosomal Functionconcept2
- Sphingolipid Signalingconcept2
- Stanley Prusiner's Prion Theory and Templated Neurodegeneration, Critically Evaluatedpaper2
- SuperAgers demonstrate pathology-cognition dissociationconcept2
- Synapse loss as primary eventconcept2
- Synaptic Competitionconcept2
- Synaptic Pathologyconcept2
- Synaptoblastic vs synaptoclastic balanceconcept2
- Syndromic Complexityconcept2
- Systemic circulating factors governing neurodegenerationconcept2
- Systemic disease beyond CNSconcept2
- Systemic disease interaction modelconcept2
- Systems approach to interconnected AD pathological hallmarksconcept2
- Tau as primary causative factor over amyloidconcept2
- Tau Biomarkersconcept2
- The Clearance Collapse — One Machinery, Three Failurespaper2
- The Failing Clock That Stops Defending the Brainstempaper2
- The Synaptic Thesis (Downloadable PDF)paper2
- Theory integration across domainsconcept2
- Three-actor-group pathogenesisconcept2
- Toxic Abeta species and PTMsconcept2
- Trained Immunityconcept2
- Transcriptomic Isoform Complexityconcept2
- TXNIP as therapeutic targetconcept2
- Vascular and inflammatory contributionsconcept2
- Vascular-metabolic-infectious convergenceconcept2
- Viral infection triggers chronic brain inflammationconcept2
- Wnt-GSK3-beta pathway integrating amyloid and tau pathologyconcept2
- Adrenergic Signalingconcept1
- Amyloid-β Restrains Microglia Twicepaper1
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper1
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper1
- BCG Vaccination in Alzheimer's Diseasepaper1
- Calcium Homeostasisconcept1
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper1
- Depression as Reversible Collapsepaper1
- Down Syndrome as the Disease Run in Fast-Forwardpaper1
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper1
- Fischer's Matrixpaper1
- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper1
- Neuroimmune Interfacenode1
- Neuroinflammationconcept1
- Oskar Fischer's Eight Stages of Plaque Formationpaper1
- Perineuronal Netsconcept1
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper1
- Re-evaluating Chini's CD38–NAD Programpaper1
- Re-evaluating Höglinger's Complex I → Tau Programpaper1
- The Biomarker Cascade (PhD Thesis)paper1
- The Cell Biology of the Word 'Ageing'paper1
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper1
- The Pedunculopontine Nucleus in Alzheimer's Diseasepaper1
- The Plaque Was Staged Before It Was Countedpaper1
- The Somatostatin Interneuron in Alzheimer's Diseasepaper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
- Wandering in Alzheimer's Diseasepaper1
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper1
- Zhen Huang's Competitive Synaptic Plasticity and the Amyloid-β Monomer Depletion Modelpaper1
- α-Synuclein Templating and Synucleinopathy Propagationpaper1
RELN Reelin, synapse & ECM–PNN 56 docs
Matched on
RELN reelin- The Brain's Architect and the Brake It Puts on Taupaper277
- Can a Drug Copy the Luckiest Mutation?paper197
- The Enzyme That Cuts the Protective Latticepaper187
- The Load-Bearing Neuronpaper177
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper163
- The Inflammasome Versus the Reelin Brakepaper134
- One Sugar Lattice, Three Jobspaper116
- Tau Kindling in the Locus Coeruleuspaper107
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper93
- Cofilin Serine 3paper87
- Norepinephrine as a Two-Armed Pincer on Taupaper85
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper80
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper62
- Reelin-ApoE receptor axis disruptionconcept53
- Cofilin Serine 3 in Alzheimer's Diseasepaper48
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper32
- Cortical Immature Neurons of Layer IIpaper30
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper29
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper29
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper26
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper25
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper21
- The Genes That Protect — Phenocopy the Fortunatepaper21
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper20
- Matrix Sulfation Nodeconcept17
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper16
- Microglial Restraint as Resiliencepaper16
- The Genetic Architecture of Neurodegeneration (PhD)paper16
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper15
- Perineuronal Netsconcept14
- The Somatostatin Interneuron in Alzheimer's Diseasepaper13
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper11
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper11
- Alzheimer's Disease — A Process in Timepaper8
- Chronic Excitatory Insufficiencyconcept8
- From Gut Ecology to the Failed Antidepressant Trialpaper8
- APOE4 Hubnode7
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper6
- The Indifferent Neuronpaper6
- Excitatory–Inhibitory Balance in Alzheimer'spaper5
- The Microglion That Silences Tau's Phosphatasepaper4
- ApoE4 structural vulnerabilityconcept3
- Immune-pathogen interaction modelconcept3
- Lipid peroxidation cascade at synapseconcept3
- Multi-cellular pathologyconcept3
- Neurovascular dysfunction as initiating eventconcept3
- Ordered Attrition and Resilience as the Two Human-Evidence Anchors of Alzheimer'spaper3
- Peroxidized ApoE as proximate causeconcept3
- Post-translational modification dysregulationconcept3
- Todd Golde's Amyloid Cascade, Read for What It Addspaper3
- Adrenergic Signalingconcept2
- Synaptic Plasticityconcept2
- Templated Tau Misfolding Across the Three Phasespaper2
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper2
- Moosmann & Sohrepaper1
- The Losing Axonpaper1
APP Amyloid & Tau core 214 docs
Matched on
amyloid precursor protein APP- Down Syndrome as the Disease Run in Fast-Forwardpaper60
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper60
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper52
- Convergent Autophagic Collapsepaper44
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper33
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper32
- Amyloid-β Restrains Microglia Twicepaper28
- The Mitochondrion as Nexus (PhD Thesis)paper26
- Scott Small's Retromer and Endosomal Theorypaper24
- Estela Area-Gómez's MAM Theorypaper23
- Gouraspaper23
- Restoring Autophagy in Neurodegenerationpaper22
- The Narrow Gate Every Mitochondrial Protein Must Passpaper22
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper20
- Autophagic Flux in Alzheimer's Diseasepaper20
- Oxidative Stress and Autophagy Failure in Alzheimer's Diseasepaper20
- The Strongest Case FOR the Amyloid Cascadepaper20
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper19
- The Genetic Architecture of Neurodegeneration (PhD)paper19
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper18
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper16
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper16
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper16
- Smallpaper16
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper16
- The Genes That Protect — Phenocopy the Fortunatepaper16
- The Losing Axonpaper16
- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper16
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper15
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper15
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper15
- From Gut Ecology to the Failed Antidepressant Trialpaper14
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper14
- The Indifferent Neuronpaper14
- Todd Golde's Amyloid Cascade, Read for What It Addspaper14
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper13
- Comparing Different Viral Triggerspaper13
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper12
- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper12
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper12
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper12
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper11
- Moosmann & Sohrepaper11
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper11
- Can Vaccines Protect Against Dementia?paper10
- Proving That Misfolded Proteins Spread Like Prionspaper10
- Ralph Nixon's Inside-Out Thesispaper10
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper10
- Fischer's Staged Deposit, 1907–1912paper9
- Iron Chelation and GPX4 Stabilizationpaper9
- Zhen Huang's Competitive Synaptic Plasticity and the Amyloid-β Monomer Depletion Modelpaper9
- Lithium in Alzheimer's Diseasepaper8
- Seth Margolis Revisitedpaper8
- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper8
- The Lipid That Kills Neurons and Spares Tumourspaper8
- The Somatostatin Interneuron in Alzheimer's Diseasepaper8
- AD caused by APP dysregulation not Abeta per seconcept7
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper7
- APP and tau pathology linked through transport disruptionconcept7
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper7
- Gene dosage of APP directly causes pathogenesisconcept7
- Mapping the Vascular onto the Genetic Dimension (PhD)paper7
- Need to understand normal APP functionconcept7
- Structural Instructions at the Synapse Are Terminated by Destruction, Not Dephosphorylationpaper7
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper6
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper6
- Cofilin Serine 3paper6
- Endosomal Traffickingconcept6
- Khachaturianpaper6
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper6
- Plaques Are Tombstones, Not Killerspaper6
- Rappoportpaper6
- APP as dependence receptorconcept5
- Axon initial segment as key disease locusconcept5
- Axonal transport failure as unifying mechanismconcept5
- CDK3 Cell Cycle Toxicityconcept5
- Dynamic and region-independent disease mechanismsconcept5
- Kinase Inhibitor Neuroprotectionconcept5
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper5
- Neuronal network degradation as substrate of dementiaconcept5
- Plaque Origin What is Establishedconcept5
- APP processing pathwayconcept4
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper4
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper4
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper4
- Chronic Excitatory Insufficiencyconcept4
- Excitatory–Inhibitory Balance in Alzheimer'spaper4
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper4
- Pavel Kalvach's Case That Alzheimer's Is Not a Disease, Gradedpaper4
- Phase IIIpaper4
- Prenatally Generated Immature Neurons and the Cellular Origin of Alzheimer's Diseasepaper4
- Stanley Prusiner's Prion Theory and Templated Neurodegeneration, Critically Evaluatedpaper4
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper4
- The Brain's Architect and the Brake It Puts on Taupaper4
- The Calcium Hypothesis and the Systems Failure Model of Alzheimer's Diseasepaper4
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper4
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper4
- The Ventral Tegmental Area in Alzheimer's Diseasepaper4
- TOMM40 Import Gateconcept4
- Vaccines That May Prevent Dementiapaper4
- Alzheimer's Disease — A Process in Timepaper3
- Anne Eckert's Neuroendocrine Theory and the Withdrawal of Protection in the Ageing Brainpaper3
- Astrocytespaper3
- Brain DNA blueprint is altered in AD neuronsconcept3
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper3
- Endosomal Nexusnode3
- Existing HIV RT inhibitors as potential AD therapeuticsconcept3
- Fischer's Sideliningpaper3
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper3
- Multidomain AD Interventionconcept3
- Ordered Attrition and Resilience as the Two Human-Evidence Anchors of Alzheimer'spaper3
- Precision Medicine ADconcept3
- Precision medicine protocolconcept3
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper3
- Retroviral-like mechanisms drive disease propagationconcept3
- Signal Insufficiency Model (SIM)concept3
- Somatic Mosaicism in ADconcept3
- Somatic recombination creates pathogenic gene variantsconcept3
- Synaptoblastic vs synaptoclastic balanceconcept3
- The Inflammasome Versus the Reelin Brakepaper3
- The Innate-Immune Sensor That Converts the Diseasepaper3
- The Load-Bearing Neuronpaper3
- Transcriptomic Isoform Complexityconcept3
- Amyloid structural diversity and toxicityconcept2
- Autophagyconcept2
- Can a Drug Copy the Luckiest Mutation?paper2
- Collapse, Traced Cell Type by Cell Typepaper2
- Denervation supersensitivityconcept2
- Depression as Reversible Collapsepaper2
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper2
- Endolysosomal Dysfunctionconcept2
- Epigenetic Repressionconcept2
- Ferroptosisconcept2
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper2
- Lipid Metabolismconcept2
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper2
- LRP1 and the Templated Spread of Misfolded Proteinpaper2
- Lysosomal Acidificationconcept2
- Margolispaper2
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper2
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper2
- Oligomer hypothesis of neurotoxicityconcept2
- One Sensor, Two Collapses — Which Arm Matters More?paper2
- Plaque-cognition dissociationconcept2
- Selective Tau Disruptionconcept2
- Standard Diagnostic Biomarkers Explainedpaper2
- Tau Scaffolding Interactionsconcept2
- Templated Tau Misfolding Across the Three Phasespaper2
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper2
- The Clearance Collapse — One Machinery, Three Failurespaper2
- The Coerulean Interface — The Brainstem Origin of Alzheimer'spaper2
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper2
- The Immune Cells That Keep the Peace — Until They Don'tpaper2
- Vesicular Traffickingconcept2
- A Counterfactual History of Alzheimer's Research Had Fischer's 1907 Findings Prevailedpaper1
- Abeta aggregation as necessary initiating eventconcept1
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper1
- Aluminum as primary environmental causeconcept1
- Aluminum driving amyloid productionconcept1
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Amyloid and tau as secondary phenomenaconcept1
- Autophagy-lysosomal failureconcept1
- Axonal Transportconcept1
- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper1
- Blocking the Aβ–ABAD Complex — A Pharmacologypaper1
- cGAS–STING in Alzheimer's Diseasepaper1
- Cholesterol Homeostasisconcept1
- Cholinergic primacy in ADconcept1
- Cofilin Serine 3 in Alzheimer's Diseasepaper1
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper1
- Cortical Immature Neurons of Layer IIpaper1
- Epigenetic regulation of AD genesconcept1
- ER Stressconcept1
- Exponential exposure-prevalence correlationconcept1
- Ferroptosis in Neurodegenerationconcept1
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper1
- Genetic evidence as gold standard for causalityconcept1
- Gut-brain axis in neuroinflammationconcept1
- Iron Brain Paradoxconcept1
- Iron Dyshomeostasisconcept1
- Long preclinical phase of AD pathologyconcept1
- Lysosomal Dysfunctionconcept1
- Microglial Lipid Regulationconcept1
- Mitochondrial Dysfunctionconcept1
- Multi-pathway AD pathophysiology reviewconcept1
- Multifactorial modulation of disease trajectoryconcept1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- Norepinephrine as a Two-Armed Pincer on Taupaper1
- One Sugar Lattice, Three Jobspaper1
- Oxidative Stressconcept1
- PANTHOSconcept1
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper1
- Peripheral Lipid Biomarkersconcept1
- PERK DLX1 Tau Axisconcept1
- Presymptomatic Lipidomic Signaturesconcept1
- Receptor-based therapeutic approachconcept1
- Silica water as protective interventionconcept1
- Sleep as the Shared Off-Line State of Every Collapse Axispaper1
- Solomon Carter Fuller's 1911 Plaque Audit, Read Beside Oskar Fischer'spaper1
- Tau Kindling in the Locus Coeruleuspaper1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Enzyme That Cuts the Protective Latticepaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper1
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper1
- The Locus Coeruleus as Phase Bridgepaper1
- The Microglion That Silences Tau's Phosphatasepaper1
- The Phase II → III Transitionpaper1
- The Synaptic Thesis (Downloadable PDF)paper1
- Translational Regulation in Tauopathyconcept1
- Vascular Pathology as a Substrate Across Phasespaper1
- Wandering in Alzheimer's Diseasepaper1
- When the Gut Writes the First Depressionpaper1
TREM2 GWAS / LOAD risk 99 docs
Matched on
s?TREM2- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper61
- The Microglial Thesis (Downloadable PDF)paper61
- The Genetic Architecture of Neurodegeneration (PhD)paper59
- The Biomarker Cascade (PhD Thesis)paper56
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper49
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper44
- Microglial Restraint as Resiliencepaper33
- The Genes That Protect — Phenocopy the Fortunatepaper33
- The Losing Axonpaper33
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper31
- Amyloid-β Restrains Microglia Twicepaper28
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper28
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper27
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper26
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper24
- The Immunometabolic Nexus of Neurodegenerationpaper22
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper20
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper17
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper13
- The Plaque Was Staged Before It Was Countedpaper13
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper11
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper10
- Mapping the Vascular onto the Genetic Dimension (PhD)paper9
- Shatz & Brottpaper9
- The Microglion That Silences Tau's Phosphatasepaper9
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper8
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper7
- Alzheimer's Disease — A Process in Timepaper7
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper7
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper7
- Oskar Fischer's Eight Stages of Plaque Formationpaper7
- The Clearance Collapse — One Machinery, Three Failurespaper7
- Cortical Immature Neurons of Layer IIpaper6
- The Mitochondrion as Nexus (PhD Thesis)paper6
- Collapse, Traced Cell Type by Cell Typepaper5
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper5
- Metabolic-Homeostatic Axisnode5
- The Bredesen ReCODE Protocol Evaluatedpaper5
- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper5
- The Innate-Immune Sensor That Converts the Diseasepaper5
- Autophagic Flux in Alzheimer's Diseasepaper4
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper4
- Neuroinflammationconcept4
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper4
- Phase IIpaper4
- Phase IIIpaper4
- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper4
- Smallpaper3
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper3
- Todd Golde's Amyloid Cascade, Read for What It Addspaper3
- Zhen Huang's Competitive Synaptic Plasticity and the Amyloid-β Monomer Depletion Modelpaper3
- Bioenergeticsconcept2
- Chronobiologic neuroprotection via melatoninconcept2
- Cognitive resilience as dynamic protective conceptconcept2
- Fischer's Eighth Stage as a Measurement of Rate Against Host Capacitypaper2
- Fischer's Staged Deposit, 1907–1912paper2
- Homeostatic Microglial Collapseconcept2
- Multifactorial prevention through modifiable risk factorsconcept2
- Neuroimmune Interfacenode2
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper2
- Plaques Are Tombstones, Not Killerspaper2
- Population-specific AD genetic signaturesconcept2
- Restoring Autophagy in Neurodegenerationpaper2
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper2
- The Phase II → III Transitionpaper2
- The Synaptic Thesis (Downloadable PDF)paper2
- The Vascular Phasing (PhD Thesis)paper2
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Age-related immune dysfunction enables neurotropic virusesconcept1
- BCG Vaccination in Alzheimer's Diseasepaper1
- Beth Stevens's Complement-Pruning Programpaper1
- Can Vaccines Protect Against Dementia?paper1
- cognitive resilienceconcept1
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper1
- Depression as Reversible Collapsepaper1
- Eight factors of dementia frameworkconcept1
- Glymphatic clearance failure amplifies pathologyconcept1
- Innate Immunityconcept1
- Integrative treatment across medical traditionsconcept1
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper1
- Microglial dysfunction as early eventconcept1
- Moosmann & Sohrepaper1
- Multi-system medicine approach to ADconcept1
- Multiple converging factors in unified tauopathy frameworkconcept1
- Neuroimmunologyconcept1
- Neuroinflammation as primary driver connecting all AD subsystemsconcept1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- Perineuronal Netsconcept1
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper1
- Rappoportpaper1
- Scott Small's Retromer and Endosomal Theorypaper1
- Standard Diagnostic Biomarkers Explainedpaper1
- Systems approach to interconnected AD pathological hallmarksconcept1
- Tau as primary causative factor over amyloidconcept1
- The Somatostatin Interneuron in Alzheimer's Diseasepaper1
- Vaccines That May Prevent Dementiapaper1
- Vascular and inflammatory contributionsconcept1
- Viral infection triggers chronic brain inflammationconcept1
NLRP3 Microglia & innate immunity 75 docs
Matched on
NLRP3- The Innate-Immune Sensor That Converts the Diseasepaper94
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper69
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper42
- Autophagic Flux in Alzheimer's Diseasepaper35
- One Sensor, Two Collapses — Which Arm Matters More?paper35
- The Mitochondrion as Nexus (PhD Thesis)paper35
- The Inflammasome Versus the Reelin Brakepaper34
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper33
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper27
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper27
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper22
- The Bredesen ReCODE Protocol Evaluatedpaper22
- The Microglion That Silences Tau's Phosphatasepaper22
- Depression as Reversible Collapsepaper21
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper19
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper14
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper14
- The Phase II → III Transitionpaper12
- Restoring Autophagy in Neurodegenerationpaper9
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper7
- The Clearance Collapse — One Machinery, Three Failurespaper7
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper6
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper6
- Autophagy as the Driver of System-Wide Agingpaper5
- Ralph Nixon's Inside-Out Thesispaper5
- The Ventral Tegmental Area in Alzheimer's Diseasepaper5
- The Immunometabolic Nexus of Neurodegenerationpaper4
- When the Gut Writes the First Depressionpaper4
- Can Vaccines Protect Against Dementia?paper3
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper3
- The Losing Axonpaper3
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper2
- Age-related immune dysfunction enables neurotropic virusesconcept2
- Alzheimer's Disease — A Process in Timepaper2
- Amyloid-β Restrains Microglia Twicepaper2
- Beth Stevens's Complement-Pruning Programpaper2
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper2
- Down Syndrome as the Disease Run in Fast-Forwardpaper2
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper2
- Homeostatic Microglial Collapseconcept2
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper2
- Neuroinflammationconcept2
- Neuroinflammation as primary driver connecting all AD subsystemsconcept2
- Systems approach to interconnected AD pathological hallmarksconcept2
- Tau Pathologyconcept2
- Viral infection triggers chronic brain inflammationconcept2
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Alzheimer's Disease as a Fifty-Year Process in Time and Spacepaper1
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper1
- Astrocytespaper1
- Autophagyconcept1
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper1
- BCG Vaccination in Alzheimer's Diseasepaper1
- Cellular Senescenceconcept1
- cGAS–STING in Alzheimer's Diseasepaper1
- Cholesterol Homeostasisconcept1
- Collapse, Traced Cell Type by Cell Typepaper1
- Energy metabolism declineconcept1
- Epigenetic and genetic interplayconcept1
- Innate Immunityconcept1
- Lifestyle and behavioral factorsconcept1
- Multifactorial etiologyconcept1
- Neuroimmunologyconcept1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- Ordered Attrition and Resilience as the Two Human-Evidence Anchors of Alzheimer'spaper1
- Phase IIpaper1
- Re-evaluating Tsai's 40 Hz Gamma Programpaper1
- Sleep as the Shared Off-Line State of Every Collapse Axispaper1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- The Cell Biology of the Word 'Ageing'paper1
- The Microglial Thesis (Downloadable PDF)paper1
- The Somatostatin Interneuron in Alzheimer's Diseasepaper1
ARHGEF15 (Ephexin5) Reelin, synapse & ECM–PNN 19 docs
Matched on
Ephexin-?5 ARHGEF15- Seth Margolis Revisitedpaper137
- Cofilin Serine 3paper96
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper71
- Margolispaper67
- Structural Instructions at the Synapse Are Terminated by Destruction, Not Dephosphorylationpaper45
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper40
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper36
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper35
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper33
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper30
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper27
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper23
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper10
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper8
- The Load-Bearing Neuronpaper7
- The Matrix as the Seventh Axis of Collapsepaper5
- The Synaptic Thesis (Downloadable PDF)paper3
- Cytoskeletal Collapse Nodenode2
- APOE4 Hubnode1
LILRB2 GWAS / LOAD risk 38 docs
Matched on
LILRB2 PirB- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper159
- The Load-Bearing Neuronpaper74
- Shatz & Brottpaper71
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper53
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper52
- Cofilin Serine 3 in Alzheimer's Diseasepaper36
- The Losing Axonpaper36
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper35
- Cofilin Serine 3paper34
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper18
- Seth Margolis Revisitedpaper13
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper13
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper8
- The Matrix as the Seventh Axis of Collapsepaper8
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper6
- The Microglial Thesis (Downloadable PDF)paper6
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper5
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper4
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper4
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper3
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper3
- Alzheimer's Disease — A Process in Timepaper2
- Collapse, Traced Cell Type by Cell Typepaper2
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper2
- Neuroimmune Interfacenode2
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper2
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper2
- The Synaptic Thesis (Downloadable PDF)paper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Endolysosomal Dysfunctionconcept1
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper1
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper1
- Microglial Immunometabolismconcept1
- Neuroimmunologyconcept1
- Perineuronal Netsconcept1
- Synaptic Competitionconcept1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- Zhen Huang's Competitive Synaptic Plasticity and the Amyloid-β Monomer Depletion Modelpaper1
PVALB (parvalbumin) Reelin, synapse & ECM–PNN 81 docs
Matched on
PVALB parvalbumin- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper44
- The Proteolytic Degradation of the Perineuronal Net and the Loss of PV Interneuronspaper44
- The Somatostatin Interneuron in Alzheimer's Diseasepaper42
- Collapse, Traced Cell Type by Cell Typepaper31
- The Matrix as the Seventh Axis of Collapsepaper30
- Fischer's Matrixpaper23
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper23
- The Perineuronal Matrix and Cortical Layer Twopaper22
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper20
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper19
- The Load-Bearing Neuronpaper18
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper17
- One Sensor, Two Collapses — Which Arm Matters More?paper14
- The Genetic Architecture of Neurodegeneration (PhD)paper14
- The Vascular Phasing (PhD Thesis)paper14
- The Ventral Tegmental Area in Alzheimer's Diseasepaper14
- Wandering in Alzheimer's Diseasepaper14
- The Phase II → III Transitionpaper13
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper12
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper11
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper11
- The Cell Biology of the Word 'Ageing'paper11
- Excitatory–Inhibitory Balance in Alzheimer'spaper10
- The Bredesen ReCODE Protocol Evaluatedpaper10
- Cofilin Serine 3 in Alzheimer's Diseasepaper8
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper8
- One Sugar Lattice, Three Jobspaper8
- Phase IIIpaper8
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper8
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper7
- Down Syndrome as the Disease Run in Fast-Forwardpaper6
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper6
- When the Gut Writes the First Depressionpaper6
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper5
- Sleep as the Shared Off-Line State of Every Collapse Axispaper5
- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper5
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper5
- The Microglial Thesis (Downloadable PDF)paper5
- Vascular Pathology as a Substrate Across Phasespaper5
- Cofilin Serine 3paper4
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper3
- Alzheimer's Disease as a Fifty-Year Process in Time and Spacepaper3
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper3
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper3
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper3
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper3
- Mapping the Vascular onto the Genetic Dimension (PhD)paper3
- Oskar Fischer's Eight Stages of Plaque Formationpaper3
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper3
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper3
- Re-evaluating Tsai's 40 Hz Gamma Programpaper3
- Templated Tau Misfolding Across the Three Phasespaper3
- The Inflammasome Versus the Reelin Brakepaper3
- The Locus Coeruleus as Phase Bridgepaper3
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper2
- Convergent Synaptic Collapseconcept2
- Homeostatic Microglial Collapseconcept2
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper2
- Ordered Attrition and Resilience as the Two Human-Evidence Anchors of Alzheimer'spaper2
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper2
- The Biomarker Cascade (PhD Thesis)paper2
- Adrenergic Signalingconcept1
- Alzheimer's Disease — A Process in Timepaper1
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Bioenergetic Collapseconcept1
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper1
- Ecce Homopaper1
- Energy Metabolismconcept1
- LC Morphology What is Establishedconcept1
- Moosmann & Sohrepaper1
- Neural Oscillationsconcept1
- PARP Inhibitors and the Locus Coeruleuspaper1
- Perineuronal Netsconcept1
- Phase Measurabilityconcept1
- Prenatally Generated Immature Neurons and the Cellular Origin of Alzheimer's Diseasepaper1
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper1
- Reelin-ApoE receptor axis disruptionconcept1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The Plaque Was Staged Before It Was Countedpaper1
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper1
PSEN1 Amyloid & Tau core 156 docs
Matched on
PSEN1 PS1 presenilin[- ]?1- Convergent Autophagic Collapsepaper44
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper37
- Restoring Autophagy in Neurodegenerationpaper25
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper23
- Estela Area-Gómez's MAM Theorypaper20
- The Genetic Architecture of Neurodegeneration (PhD)paper19
- Iron Chelation and GPX4 Stabilizationpaper15
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper14
- Khachaturianpaper13
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper12
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper12
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper12
- Comparing Different Viral Triggerspaper11
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper11
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper11
- The Calcium Hypothesis and the Systems Failure Model of Alzheimer's Diseasepaper11
- The Mitochondrion as Nexus (PhD Thesis)paper11
- Autophagic Flux in Alzheimer's Diseasepaper10
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper10
- Moosmann & Sohrepaper10
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper10
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper10
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper9
- Oxidative Stress and Autophagy Failure in Alzheimer's Diseasepaper8
- The Indifferent Neuronpaper8
- A Counterfactual History of Alzheimer's Research Had Fischer's 1907 Findings Prevailedpaper7
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper7
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper7
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper7
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper6
- Fischer's Staged Deposit, 1907–1912paper6
- From Gut Ecology to the Failed Antidepressant Trialpaper6
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper6
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper6
- Can a Drug Copy the Luckiest Mutation?paper5
- Can Vaccines Protect Against Dementia?paper5
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper4
- Cofilin Serine 3paper4
- Mapping the Vascular onto the Genetic Dimension (PhD)paper4
- Pavel Kalvach's Case That Alzheimer's Is Not a Disease, Gradedpaper4
- The Brain's Architect and the Brake It Puts on Taupaper4
- The Losing Axonpaper4
- Todd Golde's Amyloid Cascade, Read for What It Addspaper4
- Vaccines That May Prevent Dementiapaper4
- Astrocytespaper3
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper3
- Ralph Nixon's Inside-Out Thesispaper3
- Templated Tau Misfolding Across the Three Phasespaper3
- The Clearance Collapse — One Machinery, Three Failurespaper3
- The Innate-Immune Sensor That Converts the Diseasepaper3
- The Load-Bearing Neuronpaper3
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper3
- The Somatostatin Interneuron in Alzheimer's Diseasepaper3
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper3
- Amyloid-β Restrains Microglia Twicepaper2
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Calcium Homeostasisconcept2
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper2
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper2
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper2
- Cofilin Serine 3 in Alzheimer's Diseasepaper2
- Compensatory Homeostasisconcept2
- Depression as Reversible Collapsepaper2
- Excitatory Neurotransmissionconcept2
- Ferroptosisconcept2
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper2
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper2
- Lysosomal Acidificationconcept2
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper2
- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper2
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper2
- One Sensor, Two Collapses — Which Arm Matters More?paper2
- Phase IIIpaper2
- Plaques Are Tombstones, Not Killerspaper2
- Scott Small's Retromer and Endosomal Theorypaper2
- Smallpaper2
- Standard Diagnostic Biomarkers Explainedpaper2
- Synaptic Physiologyconcept2
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper2
- The Genes That Protect — Phenocopy the Fortunatepaper2
- The Immune Cells That Keep the Peace — Until They Don'tpaper2
- The Inflammasome Versus the Reelin Brakepaper2
- The Strongest Case FOR the Amyloid Cascadepaper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Abeta aggregation as necessary initiating eventconcept1
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper1
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Anne Eckert's Neuroendocrine Theory and the Withdrawal of Protection in the Ageing Brainpaper1
- APOE4 Hubnode1
- APP and tau pathology linked through transport disruptionconcept1
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper1
- Autophagic Collapseconcept1
- Autophagyconcept1
- Autophagy-lysosomal failureconcept1
- Axonal transport failure as unifying mechanismconcept1
- Blocking the Aβ–ABAD Complex — A Pharmacologypaper1
- Chronic Excitatory Insufficiencyconcept1
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper1
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- Cortical Immature Neurons of Layer IIpaper1
- Dynamic and region-independent disease mechanismsconcept1
- Endosomal Nexusnode1
- Environmental neurotoxicologyconcept1
- Epigenetic regulation of AD genesconcept1
- Ferroptosis in Neurodegenerationconcept1
- Fischer's Sideliningpaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- Gene dosage of APP directly causes pathogenesisconcept1
- Genetic evidence as gold standard for causalityconcept1
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper1
- Gut-brain axis in ADconcept1
- Gut-brain axis in neuroinflammationconcept1
- Iron Brain Paradoxconcept1
- Iron Dyshomeostasisconcept1
- Lipid Metabolismconcept1
- Lipid Peroxidationconcept1
- Lithium in Alzheimer's Diseasepaper1
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper1
- Long preclinical phase of AD pathologyconcept1
- LRP1 and the Templated Spread of Misfolded Proteinpaper1
- Lysosomal Dysfunctionconcept1
- Mapping Fischer's 1907 Histopathological Terms onto Modern Autophagy Sciencepaper1
- Metabolic-neurodegenerative disease connectionconcept1
- Microglial Restraint as Resiliencepaper1
- Multi-pathway AD pathophysiology reviewconcept1
- Multifactorial modulation of disease trajectoryconcept1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- Norepinephrine as a Two-Armed Pincer on Taupaper1
- One Sugar Lattice, Three Jobspaper1
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper1
- PERK DLX1 Tau Axisconcept1
- Rappoportpaper1
- Re-evaluating Tsai's 40 Hz Gamma Programpaper1
- Reelin-ApoE receptor axis disruptionconcept1
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper1
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper1
- Sleep as the Shared Off-Line State of Every Collapse Axispaper1
- Solomon Carter Fuller's 1911 Plaque Audit, Read Beside Oskar Fischer'spaper1
- Synaptic Pathologyconcept1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Coerulean Interface — The Brainstem Origin of Alzheimer'spaper1
- The Enzyme That Cuts the Protective Latticepaper1
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper1
- The Lipid That Kills Neurons and Spares Tumourspaper1
- The Locus Coeruleus as Phase Bridgepaper1
- The Microglion That Silences Tau's Phosphatasepaper1
- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper1
- The Phase II → III Transitionpaper1
- The Ventral Tegmental Area in Alzheimer's Diseasepaper1
- Translational Regulation in Tauopathyconcept1
- TXNIP as therapeutic targetconcept1
- When the Gut Writes the First Depressionpaper1
V-ATPase (ATP6V) Autophagy / lysosome / clearance 82 docs
Matched on
V-ATPase ATP6V vacuolar[- ]?(?:type )?ATPase- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper59
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper42
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper37
- Oxidative Stress and Autophagy Failure in Alzheimer's Diseasepaper29
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper23
- Khachaturianpaper23
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper22
- Convergent Autophagic Collapsepaper21
- Lysosomal Acidificationconcept21
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper20
- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper20
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper17
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper15
- Re-evaluating Tsai's 40 Hz Gamma Programpaper15
- Comparing Different Viral Triggerspaper13
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper12
- Restoring Autophagy in Neurodegenerationpaper12
- The Mitochondrion as Nexus (PhD Thesis)paper12
- The Clearance Collapse — One Machinery, Three Failurespaper11
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper8
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper8
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper8
- The Bredesen ReCODE Protocol Evaluatedpaper8
- Bioenergeticsconcept7
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper7
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper7
- Autophagyconcept6
- Calcium Homeostasisconcept6
- Cholesterol Homeostasisconcept5
- Ferroptosisconcept5
- Fischer's Staged Deposit, 1907–1912paper5
- Lysosomal Dysfunctionconcept5
- The Genetic Architecture of Neurodegeneration (PhD)paper5
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper5
- Mitochondrial Dysfunctionconcept4
- Plaques Are Tombstones, Not Killerspaper4
- Autophagic Flux in Alzheimer's Diseasepaper3
- Endosomal Traffickingconcept3
- Gouraspaper3
- Lipid Metabolismconcept3
- Lipid Peroxidationconcept3
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper3
- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper3
- Anti Ferroptotic Botanicalsconcept2
- Antimicrobial Defenseconcept2
- Autophagic Collapseconcept2
- BCG Immune Checkpoint Modulationconcept2
- Brain Lipid Homeostasis Restorationconcept2
- Cannabinoid Neuroprotectionconcept2
- Dietary Fatty Acid APOE4 Rescueconcept2
- Endolysosomal Dysfunctionconcept2
- Endosomal Nexusnode2
- Estela Area-Gómez's MAM Theorypaper2
- Gut Brain Axisconcept2
- Immunometabolismconcept2
- Lipid Transportconcept2
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper2
- Membrane Biologyconcept2
- Microglial Immunometabolismconcept2
- Neuroinflammationconcept2
- Oxidative Stressconcept2
- Peripheral Immunocyte Regulationconcept2
- Prenatally Generated Immature Neurons and the Cellular Origin of Alzheimer's Diseasepaper2
- Synaptic Competitionconcept2
- The Biomarker Cascade (PhD Thesis)paper2
- Trained Immunityconcept2
- Viral Pathogenesisconcept2
- Autophagic Fluxconcept1
- Energy Metabolismconcept1
- ER Stressconcept1
- Fischer's Sideliningpaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- Glial Biologyconcept1
- Iron Chelation and GPX4 Stabilizationpaper1
- Metabolic-Homeostatic Axisnode1
- Microbial Pathogenesisconcept1
- Neural Oscillationsconcept1
- Proteostasis Collapseconcept1
- The Immunometabolic Nexus of Neurodegenerationpaper1
- The Synaptic Thesis (Downloadable PDF)paper1
- TOMM40 Import Gateconcept1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
SST (somatostatin) Neuromodulator / circadian / kynurenine 30 docs
Matched on
SST somatostatin- The Somatostatin Interneuron in Alzheimer's Diseasepaper264
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper118
- Wandering in Alzheimer's Diseasepaper79
- The Load-Bearing Neuronpaper41
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper17
- Collapse, Traced Cell Type by Cell Typepaper12
- The Proteolytic Degradation of the Perineuronal Net and the Loss of PV Interneuronspaper12
- The Matrix as the Seventh Axis of Collapsepaper8
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper7
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper7
- Alzheimer's Disease as a Fifty-Year Process in Time and Spacepaper4
- Ordered Attrition and Resilience as the Two Human-Evidence Anchors of Alzheimer'spaper4
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper3
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper3
- Cofilin Serine 3 in Alzheimer's Diseasepaper2
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper2
- Reelin-ApoE receptor axis disruptionconcept2
- Cofilin Serine 3paper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- Matrix Sulfation Nodeconcept1
- Microglial Restraint as Resiliencepaper1
- One Sensor, Two Collapses — Which Arm Matters More?paper1
- One Sugar Lattice, Three Jobspaper1
- Perineuronal Netsconcept1
- Phase Measurabilityconcept1
- Templated Tau Misfolding Across the Three Phasespaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper1
LRP8 (ApoER2) Reelin, synapse & ECM–PNN 60 docs
Matched on
LRP8 ApoER2 APOER2- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper82
- The Load-Bearing Neuronpaper51
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper46
- Can a Drug Copy the Luckiest Mutation?paper37
- The Enzyme That Cuts the Protective Latticepaper35
- Cofilin Serine 3paper32
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper32
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper31
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper19
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper18
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper17
- The Brain's Architect and the Brake It Puts on Taupaper17
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper14
- Norepinephrine as a Two-Armed Pincer on Taupaper13
- The Inflammasome Versus the Reelin Brakepaper12
- Iron Chelation and GPX4 Stabilizationpaper11
- Cofilin Serine 3 in Alzheimer's Diseasepaper10
- Reelin-ApoE receptor axis disruptionconcept10
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper9
- One Sugar Lattice, Three Jobspaper7
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper6
- Alzheimer's Disease — A Process in Timepaper5
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper5
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper5
- Chronic Excitatory Insufficiencyconcept4
- Tau Kindling in the Locus Coeruleuspaper4
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper3
- Excitatory–Inhibitory Balance in Alzheimer'spaper3
- Lipid Peroxidationconcept3
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper3
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- The Matrix as the Seventh Axis of Collapsepaper3
- APOE4 Hubnode2
- Cortical Immature Neurons of Layer IIpaper2
- Endosomal Nexusnode2
- Ferroptosisconcept2
- The Synaptic Thesis (Downloadable PDF)paper2
- Adrenergic Signalingconcept1
- ApoE4 structural vulnerabilityconcept1
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper1
- Cholesterol Homeostasisconcept1
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper1
- Convergent Synaptic Collapseconcept1
- Ferroptosis in Neurodegenerationconcept1
- From Gut Ecology to the Failed Antidepressant Trialpaper1
- Immune-pathogen interaction modelconcept1
- Iron Brain Paradoxconcept1
- Iron Dyshomeostasisconcept1
- Lipid peroxidation cascade at synapseconcept1
- Matrix Sulfation Nodeconcept1
- Moosmann & Sohrepaper1
- Multi-cellular pathologyconcept1
- Neurovascular dysfunction as initiating eventconcept1
- Perineuronal Netsconcept1
- Peroxidized ApoE as proximate causeconcept1
- Post-translational modification dysregulationconcept1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Genes That Protect — Phenocopy the Fortunatepaper1
- The Somatostatin Interneuron in Alzheimer's Diseasepaper1
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper1
CGAS Microglia & innate immunity 14 docs
Matched on
cGAS CGAS- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper184
- cGAS–STING in Alzheimer's Diseasepaper127
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper124
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper74
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper8
- Mapping the Vascular onto the Genetic Dimension (PhD)paper5
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper4
- The Mitochondrion as Nexus (PhD Thesis)paper4
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper3
- The Immunometabolic Nexus of Neurodegenerationpaper2
- Autophagy as the Driver of System-Wide Agingpaper1
- Comparing Different Viral Triggerspaper1
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper1
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper1
CAMP (LL-37) Microglia & innate immunity 22 docs
Matched on
LL-?37 cathelicidin- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper297
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper110
- The Inflammasome Versus the Reelin Brakepaper36
- The Gut Ecosystem as the Upstream Originpaper21
- Gut Brain Axisconcept9
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper8
- Innate Immunityconcept7
- When the Gut Writes the First Depressionpaper5
- Anatomy of a Neurodegenerative Conduit — The Vagal Interfacepaper4
- Host Defense Peptidesconcept4
- The Losing Axonpaper4
- Oral Microbiomeconcept3
- Pathogen Driven Neurodegenerationconcept3
- Antimicrobial Defenseconcept2
- BCG Immune Checkpoint Modulationconcept2
- Immunometabolismconcept2
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper2
- Peripheral Immunocyte Regulationconcept2
- Trained Immunityconcept2
- Autophagic Fluxconcept1
- BCG Vaccination in Alzheimer's Diseasepaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
DAB1 Reelin, synapse & ECM–PNN 41 docs
Matched on
DAB1 Disabled-1- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper56
- Can a Drug Copy the Luckiest Mutation?paper47
- Cofilin Serine 3paper47
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper30
- The Enzyme That Cuts the Protective Latticepaper26
- The Load-Bearing Neuronpaper26
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper25
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper25
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper25
- The Brain's Architect and the Brake It Puts on Taupaper20
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper19
- Norepinephrine as a Two-Armed Pincer on Taupaper18
- The Inflammasome Versus the Reelin Brakepaper18
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper15
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper15
- One Sugar Lattice, Three Jobspaper12
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper11
- Cofilin Serine 3 in Alzheimer's Diseasepaper11
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper9
- Reelin-ApoE receptor axis disruptionconcept9
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper8
- Tau Kindling in the Locus Coeruleuspaper7
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper4
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper3
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper3
- Cortical Immature Neurons of Layer IIpaper3
- The Matrix as the Seventh Axis of Collapsepaper3
- Endosomal Nexusnode2
- Perineuronal Netsconcept2
- The Genes That Protect — Phenocopy the Fortunatepaper2
- The Genetic Architecture of Neurodegeneration (PhD)paper2
- The Somatostatin Interneuron in Alzheimer's Diseasepaper2
- The Synaptic Thesis (Downloadable PDF)paper2
- APOE4 Hubnode1
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Convergent Synaptic Collapseconcept1
- From Gut Ecology to the Failed Antidepressant Trialpaper1
- Lipid Peroxidationconcept1
- Matrix Sulfation Nodeconcept1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper1
MMP9 Reelin, synapse & ECM–PNN 58 docs
Matched on
MMP-?9- The Enzyme That Cuts the Protective Latticepaper92
- Phase IIIpaper91
- Mapping the Vascular onto the Genetic Dimension (PhD)paper30
- Telling Different Dementias Apartpaper30
- Amyloid-β Restrains Microglia Twicepaper23
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper23
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper20
- The Genetic Architecture of Neurodegeneration (PhD)paper20
- The Losing Axonpaper19
- The Phase II → III Transitionpaper18
- The Vascular Phasing (PhD Thesis)paper15
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper11
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper6
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper6
- Vascular Pathology as a Substrate Across Phasespaper6
- The Matrix as the Seventh Axis of Collapsepaper5
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper5
- Zhen Huang's Competitive Synaptic Plasticity and the Amyloid-β Monomer Depletion Modelpaper5
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper4
- One Sugar Lattice, Three Jobspaper4
- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper4
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper4
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper3
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper3
- Depression as Reversible Collapsepaper3
- Down Syndrome as the Disease Run in Fast-Forwardpaper3
- Fischer's Matrixpaper3
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper3
- Norepinephrine as a Two-Armed Pincer on Taupaper3
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper3
- The Microglial Thesis (Downloadable PDF)paper3
- Adrenergic Signalingconcept2
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper2
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper2
- Perineuronal Netsconcept2
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper2
- The Cell Biology of the Word 'Ageing'paper2
- The Load-Bearing Neuronpaper2
- The Locus Coeruleus as Phase Bridgepaper2
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- AD as accelerated aging of Abeta managementconcept1
- Aging accelerators and deceleratorsconcept1
- Alzheimer's Disease — A Process in Timepaper1
- Alzheimer's Disease as a Fifty-Year Process in Time and Spacepaper1
- Beth Stevens's Complement-Pruning Programpaper1
- Clearance failure vs. overproductionconcept1
- Collapse, Traced Cell Type by Cell Typepaper1
- Convergent Synaptic Collapseconcept1
- Fischer's Sideliningpaper1
- Inflamm-aging as disease driverconcept1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- Oskar Fischer's Eight Stages of Plaque Formationpaper1
- Re-evaluating Tsai's 40 Hz Gamma Programpaper1
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper1
- The Inflammasome Versus the Reelin Brakepaper1
CD38 Bioenergetic / mito / NAD 30 docs
Matched on
CD38- NAD⁺ Restoration and CD38 Inhibitionpaper118
- Re-evaluating Chini's CD38–NAD Programpaper62
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper41
- The Mitochondrion as Nexus (PhD Thesis)paper36
- PARP Inhibitors and the Locus Coeruleuspaper21
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper20
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper19
- The Cell Biology of the Word 'Ageing'paper18
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper15
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper12
- Iron Chelation and GPX4 Stabilizationpaper10
- The Genetic Architecture of Neurodegeneration (PhD)paper10
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper9
- Cellular Senescenceconcept9
- The Clearance Collapse — One Machinery, Three Failurespaper7
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper5
- Aging as root cause of ADconcept3
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper3
- Amyloid-beta as innate immune defenseconcept3
- Inflammaging integrates hallmarks of agingconcept3
- Mapping the Vascular onto the Genetic Dimension (PhD)paper3
- NAD+ depletion drives neurodegenerationconcept3
- Brain Immune Interfaceconcept1
- Immune Checkpoint Therapyconcept1
- Immunometabolic Checkpointsconcept1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Meningeal T Cell Regulationconcept1
- Necrotic Cell Deathconcept1
- Phagocytic Clearanceconcept1
- Re-evaluating Tsai's 40 Hz Gamma Programpaper1
STING Microglia & innate immunity 15 docs
Matched on
TMEM173 STING- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper212
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper118
- cGAS–STING in Alzheimer's Diseasepaper49
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper27
- Mapping the Vascular onto the Genetic Dimension (PhD)paper5
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper4
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper3
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper3
- The Immunometabolic Nexus of Neurodegenerationpaper2
- The Mitochondrion as Nexus (PhD Thesis)paper2
- Autophagy as the Driver of System-Wide Agingpaper1
- Comparing Different Viral Triggerspaper1
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper1
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
LRP1 Reelin, synapse & ECM–PNN 32 docs
Matched on
LRP1- LRP1 and the Templated Spread of Misfolded Proteinpaper168
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper72
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper43
- Different Tau Strains Cause Different Diseasespaper20
- Mapping the Vascular onto the Genetic Dimension (PhD)paper20
- Stanley Prusiner's Prion Theory and Templated Neurodegeneration, Critically Evaluatedpaper12
- Vascular Pathology as a Substrate Across Phasespaper9
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper8
- α-Synuclein Templating and Synucleinopathy Propagationpaper7
- Proving That Misfolded Proteins Spread Like Prionspaper5
- The Locus Coeruleus as Phase Bridgepaper5
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper5
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper4
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper4
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper3
- Templated Tau Misfolding Across the Three Phasespaper3
- The Vascular Phasing (PhD Thesis)paper3
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper2
- Alzheimer's Disease — A Process in Timepaper2
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper2
- Endosomal Traffickingconcept2
- Restoring Autophagy in Neurodegenerationpaper2
- The Brain's Border Gatepaper2
- The Indifferent Neuronpaper2
- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper2
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Can a Drug Copy the Luckiest Mutation?paper1
- Cholesterol Homeostasisconcept1
- Glymphatic Clearance Failure in Alzheimer's Disease and the Noradrenergic Switchpaper1
- Gouraspaper1
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper1
- The Cell Biology of the Word 'Ageing'paper1
SORL1 GWAS / LOAD risk 47 docs
Matched on
SORL1 SORLA- Scott Small's Retromer and Endosomal Theorypaper88
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper55
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper46
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper40
- Smallpaper30
- Beth Stevens's Complement-Pruning Programpaper24
- Cofilin Serine 3paper13
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper9
- The Genetic Architecture of Neurodegeneration (PhD)paper9
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper9
- SORL1 Lysosomal Functionconcept5
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper5
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper4
- Endosomal Traffickingconcept4
- SorLA Lipid ER Regulationconcept4
- Antimicrobial hypothesis of amyloidconcept3
- BBB breakdown cascadeconcept3
- Circadian Immune Regulationconcept3
- Human-germ interaction modelconcept3
- Neuroimmune Surveillanceconcept3
- Neurovascular unit as disease originconcept3
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper2
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper2
- Endosomal Nexusnode2
- Entropy as organizing principleconcept2
- Evolutionary mismatch hypothesisconcept2
- Microglial Protein Biomarkersconcept2
- Modifiability of AD riskconcept2
- Mosaic model of aging brainconcept2
- Seth Margolis Revisitedpaper2
- The Mitochondrion as Nexus (PhD Thesis)paper2
- The Synaptic Thesis (Downloadable PDF)paper2
- Transcriptional Pause Releaseconcept2
- Autophagic Collapseconcept1
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper1
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper1
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper1
- Convergent Autophagic Collapsepaper1
- Estela Area-Gómez's MAM Theorypaper1
- Gouraspaper1
- Khachaturianpaper1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Moosmann & Sohrepaper1
- Rappoportpaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Clearance Collapse — One Machinery, Three Failurespaper1
C4 (complement) Microglia & innate immunity 37 docs
Matched on
C4d C4b- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper80
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper62
- Shatz & Brottpaper57
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper25
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper23
- The Load-Bearing Neuronpaper23
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper14
- The Matrix as the Seventh Axis of Collapsepaper10
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper9
- Cofilin Serine 3 in Alzheimer's Diseasepaper9
- The Losing Axonpaper9
- Cofilin Serine 3paper8
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper6
- The Microglial Thesis (Downloadable PDF)paper6
- Collapse, Traced Cell Type by Cell Typepaper5
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper4
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper4
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper4
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper4
- The Phase II → III Transitionpaper4
- Seth Margolis Revisitedpaper3
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper2
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper2
- Neuroimmune Interfacenode2
- The Genetic Architecture of Neurodegeneration (PhD)paper2
- The Synaptic Thesis (Downloadable PDF)paper2
- Alzheimer's Disease — A Process in Timepaper1
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper1
- Down Syndrome as the Disease Run in Fast-Forwardpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper1
- Neuroimmunologyconcept1
- Neuroinflammationconcept1
- Perineuronal Netsconcept1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Cell Biology of the Word 'Ageing'paper1
ACAN (aggrecan) Reelin, synapse & ECM–PNN 63 docs
Matched on
ACAN aggrecan- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper26
- The Perineuronal Matrix and Cortical Layer Twopaper23
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper16
- The Proteolytic Degradation of the Perineuronal Net and the Loss of PV Interneuronspaper15
- The Matrix as the Seventh Axis of Collapsepaper13
- The Phase II → III Transitionpaper13
- The Plaque Was Staged Before It Was Countedpaper13
- One Sugar Lattice, Three Jobspaper12
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper12
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper10
- From Gut Ecology to the Failed Antidepressant Trialpaper10
- One Sensor, Two Collapses — Which Arm Matters More?paper9
- Phase IIIpaper9
- Templated Tau Misfolding Across the Three Phasespaper9
- The Genetic Architecture of Neurodegeneration (PhD)paper9
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper9
- Fischer's Matrixpaper8
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper8
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper8
- Tau Kindling in the Locus Coeruleuspaper7
- The Enzyme That Cuts the Protective Latticepaper7
- The Load-Bearing Neuronpaper7
- Down Syndrome as the Disease Run in Fast-Forwardpaper6
- Oskar Fischer's Eight Stages of Plaque Formationpaper6
- Perineuronal Netsconcept6
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper6
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper5
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper5
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper5
- The Microglial Thesis (Downloadable PDF)paper5
- Collapse, Traced Cell Type by Cell Typepaper4
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper4
- Alzheimer's Disease — A Process in Timepaper3
- Can a Drug Copy the Luckiest Mutation?paper3
- cognitive resilienceconcept3
- Fischer's Eighth Stage as a Measurement of Rate Against Host Capacitypaper3
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper3
- Norepinephrine as a Two-Armed Pincer on Taupaper3
- The Inflammasome Versus the Reelin Brakepaper3
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper3
- Depression as Reversible Collapsepaper2
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper2
- Microglial Restraint as Resiliencepaper2
- The Biomarker Cascade (PhD Thesis)paper2
- The Brain's Architect and the Brake It Puts on Taupaper2
- The Somatostatin Interneuron in Alzheimer's Diseasepaper2
- Adrenergic Signalingconcept1
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper1
- Alzheimer's Disease as a Fifty-Year Process in Time and Spacepaper1
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper1
- Cofilin Serine 3 in Alzheimer's Diseasepaper1
- Convergent Synaptic Collapseconcept1
- Cortical Immature Neurons of Layer IIpaper1
- Ecce Homopaper1
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Homeostatic Microglial Collapseconcept1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- Ordered Attrition and Resilience as the Two Human-Evidence Anchors of Alzheimer'spaper1
- The Cell Biology of the Word 'Ageing'paper1
- The Locus Coeruleus as Phase Bridgepaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
BDNF Trophic / exercise / resilience 32 docs
Matched on
BDNF- BDNF and the Trophic Failure of the Synapse in Alzheimer's Diseasepaper186
- Depression as Reversible Collapsepaper29
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper16
- Lithium in Alzheimer's Diseasepaper13
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper12
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper11
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper10
- Why Exercise Prevents but Does Not Curepaper8
- The Indifferent Neuronpaper7
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper5
- Restoring Autophagy in Neurodegenerationpaper5
- When the Gut Writes the First Depressionpaper4
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper3
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper3
- Autophagy-metabolism crosstalk in ADconcept2
- cognitive resilienceconcept2
- Energy failure as primary AD driverconcept2
- From Gut Ecology to the Failed Antidepressant Trialpaper2
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper2
- Sigma-1 receptor-mediated neuroprotectionconcept2
- SSRI repurposing for neurodegenerationconcept2
- Synaptic Plasticityconcept2
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- Adult Neurogenesisconcept1
- Can Vaccines Protect Against Dementia?paper1
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper1
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper1
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- Plaques Are Tombstones, Not Killerspaper1
- Prenatally Generated Immature Neurons and the Cellular Origin of Alzheimer's Diseasepaper1
MTOR Autophagy / lysosome / clearance 59 docs
Matched on
mTOR MTOR mTORC1 mTORC2- Restoring Autophagy in Neurodegenerationpaper29
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper26
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper22
- Autophagic Flux in Alzheimer's Diseasepaper20
- The Clearance Collapse — One Machinery, Three Failurespaper18
- Depression as Reversible Collapsepaper17
- Autophagy as the Driver of System-Wide Agingpaper13
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper12
- The Bredesen ReCODE Protocol Evaluatedpaper12
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper11
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper10
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper9
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper7
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper6
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper6
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper6
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper6
- BCG Vaccination in Alzheimer's Diseasepaper5
- Metabolic-Homeostatic Axisnode5
- The Immunometabolic Nexus of Neurodegenerationpaper5
- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper4
- Comparing Different Viral Triggerspaper4
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper4
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper4
- The Mitochondrion as Nexus (PhD Thesis)paper4
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper3
- Can Vaccines Protect Against Dementia?paper3
- Lithium in Alzheimer's Diseasepaper3
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper3
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper3
- When the Gut Writes the First Depressionpaper3
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper2
- Bioenergeticsconcept2
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper2
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper2
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper2
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper2
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper2
- The Biomarker Cascade (PhD Thesis)paper2
- The Genetic Architecture of Neurodegeneration (PhD)paper2
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Astrocytespaper1
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper1
- Cellular Senescenceconcept1
- Convergent Autophagic Collapsepaper1
- Iron Chelation and GPX4 Stabilizationpaper1
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- Ralph Nixon's Inside-Out Thesispaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Losing Axonpaper1
- The Microglial Thesis (Downloadable PDF)paper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
- Vaccines That May Prevent Dementiapaper1
TARDBP (TDP-43) Neurodegeneration overlap 57 docs
Matched on
TARDBP TDP-?43- The Indifferent Neuronpaper30
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper25
- The Mitochondrion as Nexus (PhD Thesis)paper19
- Proving That Misfolded Proteins Spread Like Prionspaper17
- The Genetic Architecture of Neurodegeneration (PhD)paper17
- Restoring Autophagy in Neurodegenerationpaper16
- Telling Different Dementias Apartpaper15
- Estela Area-Gómez's MAM Theorypaper13
- Pavel Kalvach's Case That Alzheimer's Is Not a Disease, Gradedpaper9
- Stanley Prusiner's Prion Theory and Templated Neurodegeneration, Critically Evaluatedpaper9
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper8
- Neurotropic Viral Invasion of the Central Nervous Systempaper7
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper6
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper6
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper5
- Prenatally Generated Immature Neurons and the Cellular Origin of Alzheimer's Diseasepaper5
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper4
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper3
- Convergent Autophagic Collapsepaper3
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper3
- Mapping the Vascular onto the Genetic Dimension (PhD)paper3
- The Load-Bearing Neuronpaper3
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper3
- The Somatostatin Interneuron in Alzheimer's Diseasepaper3
- Todd Golde's Amyloid Cascade, Read for What It Addspaper3
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper2
- cGAS–STING in Alzheimer's Diseasepaper2
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper2
- From Gut Ecology to the Failed Antidepressant Trialpaper2
- LRP1 and the Templated Spread of Misfolded Proteinpaper2
- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper2
- Phase Measurabilityconcept2
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper2
- Scott Small's Retromer and Endosomal Theorypaper2
- Templated Tau Misfolding Across the Three Phasespaper2
- A Counterfactual History of Alzheimer's Research Had Fischer's 1907 Findings Prevailedpaper1
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Astrocytespaper1
- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper1
- Different Tau Strains Cause Different Diseasespaper1
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
- Fischer's Sideliningpaper1
- Khachaturianpaper1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper1
- Microglial Lipid Regulationconcept1
- Peripheral Lipid Biomarkersconcept1
- Phase IIIpaper1
- Presymptomatic Lipidomic Signaturesconcept1
- Standard Diagnostic Biomarkers Explainedpaper1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- The Calcium Hypothesis and the Systems Failure Model of Alzheimer's Diseasepaper1
- The Glial Consortium and the Temporal Architecture of Neurodegenerationpaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Losing Axonpaper1
- Three Subtractive Alzheimer's Trials That Engaged Their Target and Left Patients Worsepaper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
PARP1 Bioenergetic / mito / NAD 34 docs
Matched on
PARP-?1 PARP1- PARP Inhibitors and the Locus Coeruleuspaper82
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper39
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper22
- NAD⁺ Restoration and CD38 Inhibitionpaper13
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper13
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper12
- Re-evaluating Chini's CD38–NAD Programpaper8
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper7
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper7
- The Vascular Phasing (PhD Thesis)paper7
- cGAS–STING in Alzheimer's Diseasepaper6
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper6
- The Cell Biology of the Word 'Ageing'paper6
- The Genetic Architecture of Neurodegeneration (PhD)paper6
- Plaques Are Tombstones, Not Killerspaper5
- The Locus Coeruleus as Phase Bridgepaper4
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper3
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper2
- Alzheimer's Disease — A Process in Timepaper2
- Bioenergetic Collapseconcept2
- Collapse, Traced Cell Type by Cell Typepaper2
- Down Syndrome as the Disease Run in Fast-Forwardpaper2
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper2
- The Clearance Collapse — One Machinery, Three Failurespaper2
- Vascular Pathology as a Substrate Across Phasespaper2
- Alzheimer's Disease as a Fifty-Year Process in Time and Spacepaper1
- Anatomy of a Neurodegenerative Conduit — The Vagal Interfacepaper1
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper1
- Energy Metabolismconcept1
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Re-evaluating Höglinger's Complex I → Tau Programpaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
RHOA Reelin, synapse & ECM–PNN 27 docs
Matched on
RhoA RHOA- Cofilin Serine 3paper39
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper36
- Seth Margolis Revisitedpaper31
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper24
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper17
- Margolispaper17
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper13
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper12
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper10
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper10
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper6
- The Load-Bearing Neuronpaper6
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper6
- Convergent signaling through Wnt-PCP-RhoA-ROCKconcept5
- Structural Instructions at the Synapse Are Terminated by Destruction, Not Dephosphorylationpaper5
- The Matrix as the Seventh Axis of Collapsepaper5
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper4
- Cytoskeletal disorder as core pathologyconcept3
- Glial contribution to neurodegenerationconcept3
- Locus coeruleus as ground zeroconcept3
- The Synaptic Thesis (Downloadable PDF)paper3
- Cytoskeletal Collapse Nodenode2
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper2
- APOE4 Hubnode1
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper1
- Dynamics of Synaptic Competitionpaper1
GSK3B Amyloid & Tau core 54 docs
Matched on
GSK3B GSK-?3β GSK-?3beta GSK-?3- Lithium in Alzheimer's Diseasepaper93
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper18
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper10
- Three Subtractive Alzheimer's Trials That Engaged Their Target and Left Patients Worsepaper10
- Norepinephrine as a Two-Armed Pincer on Taupaper9
- The Inflammasome Versus the Reelin Brakepaper9
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper8
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper8
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper7
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper6
- The Matrix as the Seventh Axis of Collapsepaper5
- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper3
- Restoring Autophagy in Neurodegenerationpaper3
- The Synaptic Thesis (Downloadable PDF)paper3
- Wnt-GSK3-beta pathway integrating amyloid and tau pathologyconcept3
- Can a Drug Copy the Luckiest Mutation?paper2
- Cofilin Serine 3paper2
- Cytoskeletal Collapse Nodenode2
- Cytoskeletal Perturbationstage2
- Down Syndrome as the Disease Run in Fast-Forwardpaper2
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper2
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper2
- Plaques Are Tombstones, Not Killerspaper2
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper2
- Tau Kindling in the Locus Coeruleuspaper2
- Tau Pathologyconcept2
- The Brain's Architect and the Brake It Puts on Taupaper2
- Adrenergic Signalingconcept1
- Alzheimer's Disease — A Process in Timepaper1
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Amyloid plaques as fibrotic scar tissue from BBB repairconcept1
- Autophagic Flux in Alzheimer's Diseasepaper1
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper1
- Gouraspaper1
- Lipid Metabolismconcept1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Microbleeds as initiating vascular event in ADconcept1
- Multifactorial risk accumulation modelconcept1
- Neurovascular injury-repair cycle driving disease progressionconcept1
- One Sugar Lattice, Three Jobspaper1
- Perineuronal Netsconcept1
- Re-evaluating Höglinger's Complex I → Tau Programpaper1
- Reelin-ApoE receptor axis disruptionconcept1
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper1
- Resilience as key to understanding AD clinical expressionconcept1
- Scott Small's Retromer and Endosomal Theorypaper1
- Somatic mutations as novel therapeutic targetsconcept1
- SuperAgers demonstrate pathology-cognition dissociationconcept1
- The Calcium Hypothesis and the Systems Failure Model of Alzheimer's Diseasepaper1
- The Genes That Protect — Phenocopy the Fortunatepaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper1
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
HSD17B10 Bioenergetic / mito / NAD 4 docs
Matched on
HSD17B10 HSD10 ABAD 17β-HSD10 17beta-HSD10GPX4 Oxidative stress & ferroptosis 20 docs
Matched on
GPX4- Iron Chelation and GPX4 Stabilizationpaper89
- Phase IIpaper54
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper24
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper15
- NAD⁺ Restoration and CD38 Inhibitionpaper9
- Ferroptosisconcept6
- The Genetic Architecture of Neurodegeneration (PhD)paper6
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper4
- Lipid Peroxidationconcept4
- The Locus Coeruleus as Phase Bridgepaper4
- Ferroptosis in Neurodegenerationconcept3
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper3
- Oxidative Stressconcept3
- Iron Brain Paradoxconcept2
- Iron Dyshomeostasisconcept2
- The Clearance Collapse — One Machinery, Three Failurespaper2
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Phase II → III Transitionpaper1
CAV1 (caveolin-1) Vascular / BBB 12 docs
Matched on
CAV1 caveolin-?1- The Indifferent Neuronpaper141
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper52
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper7
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper3
- Cholesterol Homeostasisconcept3
- Synaptic Plasticityconcept2
- The Calcium Hypothesis and the Systems Failure Model of Alzheimer's Diseasepaper2
- The Ventral Tegmental Area in Alzheimer's Diseasepaper2
- AI Disease Model Discoveryconcept1
- Asymptomatic AD Phenotypingconcept1
- Autophagyconcept1
- Membrane Lipid Dysregulationconcept1
SPI1 GWAS / LOAD risk 10 docs
Matched on
SPI1 PU\.1- Amyloid-β Restrains Microglia Twicepaper154
- The Losing Axonpaper23
- The Genetic Architecture of Neurodegeneration (PhD)paper8
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper7
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- BCG Vaccination in Alzheimer's Diseasepaper1
- Fischer's Staged Deposit, 1907–1912paper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Innate-Immune Sensor That Converts the Diseasepaper1
TFEB Autophagy / lysosome / clearance 41 docs
Matched on
TFEB- Restoring Autophagy in Neurodegenerationpaper34
- Autophagic Flux in Alzheimer's Diseasepaper30
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper16
- The Clearance Collapse — One Machinery, Three Failurespaper11
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper10
- The Bredesen ReCODE Protocol Evaluatedpaper9
- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper7
- The Genetic Architecture of Neurodegeneration (PhD)paper7
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper6
- Convergent Autophagic Collapsepaper5
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper5
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper5
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper4
- Cofilin Serine 3paper4
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper4
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper3
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper3
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper3
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper3
- The Mitochondrion as Nexus (PhD Thesis)paper3
- A Counterfactual History of Alzheimer's Research Had Fischer's 1907 Findings Prevailedpaper2
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper2
- Comparing Different Viral Triggerspaper2
- Gut Brain Axisconcept2
- Ralph Nixon's Inside-Out Thesispaper2
- Autophagic Fluxconcept1
- Autophagyconcept1
- Autophagy as the Driver of System-Wide Agingpaper1
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper1
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper1
- Gouraspaper1
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper1
- Lysosomal Acidificationconcept1
- Lysosomal Dysfunctionconcept1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Microbial Pathogenesisconcept1
- Proteostasis Collapseconcept1
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper1
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper1
- Templated Tau Misfolding Across the Three Phasespaper1
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper1
VCAM1 Vascular / BBB 8 docs
Matched on
VCAM-?1- The Vascular Phasing (PhD Thesis)paper75
- Vascular Pathology as a Substrate Across Phasespaper67
- Mapping the Vascular onto the Genetic Dimension (PhD)paper48
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper3
- Alzheimer's Disease — A Process in Timepaper1
- Anatomy of a Neurodegenerative Conduit — The Vagal Interfacepaper1
- Autophagy as the Driver of System-Wide Agingpaper1
- Can Vaccines Protect Against Dementia?paper1
PP2A Amyloid & Tau core 24 docs
Matched on
PP2A PPP2CA- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper48
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper36
- The Microglion That Silences Tau's Phosphatasepaper30
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper21
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper12
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper10
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper7
- Tau Kindling in the Locus Coeruleuspaper4
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper2
- Cofilin Serine 3paper2
- Tau Pathologyconcept2
- The Innate-Immune Sensor That Converts the Diseasepaper2
- The Lipid That Kills Neurons and Spares Tumourspaper2
- Adrenergic Signalingconcept1
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Atherosclerosis as AD driverconcept1
- Gravity-dependent brain vulnerabilityconcept1
- Head-down time and dementiaconcept1
- Lipid Metabolismconcept1
- Lithium in Alzheimer's Diseasepaper1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Re-evaluating Höglinger's Complex I → Tau Programpaper1
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper1
- Vascular-sleep interactionconcept1
TNF Microglia & innate immunity 56 docs
Matched on
TNF- The Losing Axonpaper33
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper14
- The Immunometabolic Nexus of Neurodegenerationpaper10
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper8
- Anti-TNF-alpha therapeutic strategyconcept7
- TNF-alpha as central AD mediatorconcept7
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper6
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper6
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper6
- Activated microglia imaging for treatment guidanceconcept5
- Anatomy of a Neurodegenerative Conduit — The Vagal Interfacepaper5
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper5
- Glial-driven neuroinflammatory disease modelconcept5
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper5
- Restoring Autophagy in Neurodegenerationpaper5
- Amyloid-β Restrains Microglia Twicepaper3
- Neurotropic Viral Invasion of the Central Nervous Systempaper3
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper3
- BCG Vaccination in Alzheimer's Diseasepaper2
- Can Vaccines Protect Against Dementia?paper2
- Cellular Senescenceconcept2
- Depression as Reversible Collapsepaper2
- Endolysosomal Dysfunctionconcept2
- Lithium in Alzheimer's Diseasepaper2
- Microglial Immunometabolismconcept2
- NAD⁺ Restoration and CD38 Inhibitionpaper2
- Neuroinflammationconcept2
- Phase IIpaper2
- Phase IIIpaper2
- Synaptic Competitionconcept2
- Vascular Pathology as a Substrate Across Phasespaper2
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Astrocytespaper1
- Autophagic Collapseconcept1
- Autophagy as the Driver of System-Wide Agingpaper1
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper1
- Beth Stevens's Complement-Pruning Programpaper1
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper1
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper1
- Convergent Autophagic Collapsepaper1
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
- Innate Immunityconcept1
- Lysosomal Acidificationconcept1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Moosmann & Sohrepaper1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- Plaques Are Tombstones, Not Killerspaper1
- The Biomarker Cascade (PhD Thesis)paper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper1
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper1
- The Vascular Phasing (PhD Thesis)paper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
- Vaccines That May Prevent Dementiapaper1
- Zhen Huang's Competitive Synaptic Plasticity and the Amyloid-β Monomer Depletion Modelpaper1
FYN Amyloid & Tau core 26 docs
Matched on
Fyn FYN- Cofilin Serine 3paper47
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper42
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper12
- Can a Drug Copy the Luckiest Mutation?paper12
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper11
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper9
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper8
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper7
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper6
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper5
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper4
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper3
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper2
- Seth Margolis Revisitedpaper2
- The Losing Axonpaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Comparing Different Viral Triggerspaper1
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper1
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper1
- Moosmann & Sohrepaper1
- Rappoportpaper1
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper1
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper1
- The Inflammasome Versus the Reelin Brakepaper1
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper1
- The Strongest Case FOR the Amyloid Cascadepaper1
BACE1 Amyloid & Tau core 65 docs
Matched on
BACE1- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper19
- The Genes That Protect — Phenocopy the Fortunatepaper14
- The Lipid That Kills Neurons and Spares Tumourspaper13
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper10
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper9
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper6
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper5
- Fischer's Staged Deposit, 1907–1912paper4
- Mapping the Vascular onto the Genetic Dimension (PhD)paper4
- Restoring Autophagy in Neurodegenerationpaper4
- The Indifferent Neuronpaper4
- Vascular Pathology as a Substrate Across Phasespaper4
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper3
- Endosomal Traffickingconcept3
- Lithium in Alzheimer's Diseasepaper3
- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper3
- Smallpaper3
- Amyloid clearance as important as depositionconcept2
- Blood-based biomarker panels for preclinical detectionconcept2
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper2
- Endolysosomal Dysfunctionconcept2
- Epigenetic Repressionconcept2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- Gouraspaper2
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper2
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper2
- Nuclear pathology as early AD mechanismconcept2
- Oskar Fischer's Eight Stages of Plaque Formationpaper2
- Oxidative Stress and Autophagy Failure in Alzheimer's Diseasepaper2
- Plaques Are Tombstones, Not Killerspaper2
- Probabilistic multi-cause disease etiologyconcept2
- Scott Small's Retromer and Endosomal Theorypaper2
- Selective Tau Disruptionconcept2
- Tau Scaffolding Interactionsconcept2
- The Genetic Architecture of Neurodegeneration (PhD)paper2
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper2
- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper2
- The Plaque Was Staged Before It Was Countedpaper2
- Vesicular Traffickingconcept2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Aluminum as primary environmental causeconcept1
- Aluminum driving amyloid productionconcept1
- Autophagy Dysfunctionconcept1
- Axonal Transportconcept1
- BDNF and the Trophic Failure of the Synapse in Alzheimer's Diseasepaper1
- Can a Drug Copy the Luckiest Mutation?paper1
- Can Vaccines Protect Against Dementia?paper1
- Cholesterol Homeostasisconcept1
- Endosomal Nexusnode1
- Environmental neurotoxicologyconcept1
- Exponential exposure-prevalence correlationconcept1
- Gut-brain axis in ADconcept1
- Innate Immunityconcept1
- Lipid Metabolismconcept1
- Metabolic-neurodegenerative disease connectionconcept1
- Ralph Nixon's Inside-Out Thesispaper1
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper1
- Silica water as protective interventionconcept1
- Sphingolipid Signalingconcept1
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper1
- The Calcium Hypothesis and the Systems Failure Model of Alzheimer's Diseasepaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The Narrow Gate Every Mitochondrial Protein Must Passpaper1
- The Synaptic Thesis (Downloadable PDF)paper1
- TXNIP as therapeutic targetconcept1
IDO1 Neuromodulator / circadian / kynurenine 10 docs
Matched on
IDO1 IDO- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper92
- From Gut Ecology to the Failed Antidepressant Trialpaper26
- Depression as Reversible Collapsepaper23
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper21
- The Biomarker Cascade (PhD Thesis)paper7
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper2
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- The Coerulean Interface — The Brainstem Origin of Alzheimer'spaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
C1QA Microglia & innate immunity 53 docs
Matched on
C1q C1QA C1QB- Beth Stevens's Complement-Pruning Programpaper19
- The Phase II → III Transitionpaper17
- The Genetic Architecture of Neurodegeneration (PhD)paper10
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper8
- The Losing Axonpaper8
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper6
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper6
- Phase IIIpaper6
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper5
- Collapse, Traced Cell Type by Cell Typepaper4
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper4
- The Load-Bearing Neuronpaper4
- The Somatostatin Interneuron in Alzheimer's Diseasepaper4
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper4
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper3
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper3
- Alzheimer's Disease — A Process in Timepaper3
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper3
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper3
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper3
- Shatz & Brottpaper3
- The Microglial Thesis (Downloadable PDF)paper3
- Antimicrobial hypothesis of amyloidconcept2
- BBB breakdown cascadeconcept2
- Circadian Immune Regulationconcept2
- Down Syndrome as the Disease Run in Fast-Forwardpaper2
- Human-germ interaction modelconcept2
- Neuroimmune Surveillanceconcept2
- Neurovascular unit as disease originconcept2
- Phase IIpaper2
- Seth Margolis Revisitedpaper2
- SORL1 Lysosomal Functionconcept2
- The Cell Biology of the Word 'Ageing'paper2
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper2
- The Mitochondrion as Nexus (PhD Thesis)paper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper1
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper1
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Microglial Restraint as Resiliencepaper1
- Neuroimmune Interfacenode1
- Neuroinflammationconcept1
- Plaques Are Tombstones, Not Killerspaper1
- Scott Small's Retromer and Endosomal Theorypaper1
- Synaptic Pathologyconcept1
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Matrix as the Seventh Axis of Collapsepaper1
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper1
- The Synaptic Thesis (Downloadable PDF)paper1
PYCARD Microglia & innate immunity 19 docs
Matched on
PYCARD ASC- The Innate-Immune Sensor That Converts the Diseasepaper53
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper40
- One Sensor, Two Collapses — Which Arm Matters More?paper17
- The Inflammasome Versus the Reelin Brakepaper16
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper8
- The Mitochondrion as Nexus (PhD Thesis)paper7
- The Microglion That Silences Tau's Phosphatasepaper5
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper5
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper4
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper3
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper3
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper3
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper2
- Autophagy as the Driver of System-Wide Agingpaper1
- Depression as Reversible Collapsepaper1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Phase IIpaper1
- Tau Pathologyconcept1
- The Bredesen ReCODE Protocol Evaluatedpaper1
EPHB2 Reelin, synapse & ECM–PNN 15 docs
Matched on
EphB2 EPHB2- Cofilin Serine 3paper25
- Seth Margolis Revisitedpaper17
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper17
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper16
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper13
- Margolispaper12
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper11
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper10
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper10
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper9
- Structural Instructions at the Synapse Are Terminated by Destruction, Not Dephosphorylationpaper9
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper8
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper6
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper5
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper1
CDC42 Reelin, synapse & ECM–PNN 14 docs
Matched on
CDC42- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper32
- Cofilin Serine 3paper25
- Seth Margolis Revisitedpaper19
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper18
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper16
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper13
- Margolispaper11
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper8
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper6
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper6
- Structural Instructions at the Synapse Are Terminated by Destruction, Not Dephosphorylationpaper6
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper2
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper2
- The Load-Bearing Neuronpaper1
SQSTM1 (p62) Autophagy / lysosome / clearance 29 docs
Matched on
SQSTM1 p62- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper34
- Restoring Autophagy in Neurodegenerationpaper23
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper17
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper14
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper8
- Autophagic Flux in Alzheimer's Diseasepaper8
- Astrocytespaper6
- Autophagy as the Driver of System-Wide Agingpaper6
- The Genetic Architecture of Neurodegeneration (PhD)paper5
- The Immunometabolic Nexus of Neurodegenerationpaper5
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper4
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper4
- Anne Eckert's Neuroendocrine Theory and the Withdrawal of Protection in the Ageing Brainpaper3
- Convergent Autophagic Collapsepaper3
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper3
- The Clearance Collapse — One Machinery, Three Failurespaper3
- The Mitochondrion as Nexus (PhD Thesis)paper3
- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper2
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper2
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper2
- The Bredesen ReCODE Protocol Evaluatedpaper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Lithium in Alzheimer's Diseasepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper1
- Phase IIpaper1
- Plaques Are Tombstones, Not Killerspaper1
PINK1 Bioenergetic / mito / NAD 30 docs
Matched on
PINK1- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper23
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper17
- The Mitochondrion as Nexus (PhD Thesis)paper17
- The Narrow Gate Every Mitochondrial Protein Must Passpaper17
- The Genetic Architecture of Neurodegeneration (PhD)paper14
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper11
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper8
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper7
- TOMM40 Import Gateconcept6
- Autophagy as the Driver of System-Wide Agingpaper5
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper5
- The Bredesen ReCODE Protocol Evaluatedpaper4
- Autophagic Flux in Alzheimer's Diseasepaper3
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper3
- The Clearance Collapse — One Machinery, Three Failurespaper3
- Collapse, Traced Cell Type by Cell Typepaper2
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper2
- Mapping the Vascular onto the Genetic Dimension (PhD)paper2
- Ralph Nixon's Inside-Out Thesispaper2
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Alzheimer's Disease — A Process in Timepaper1
- cGAS–STING in Alzheimer's Diseasepaper1
- Comparing Different Viral Triggerspaper1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- Oxidative Stress and Autophagy Failure in Alzheimer's Diseasepaper1
- Phase IIpaper1
- Restoring Autophagy in Neurodegenerationpaper1
- The Cell Biology of the Word 'Ageing'paper1
- The Glial Consortium and the Temporal Architecture of Neurodegenerationpaper1
NFKB1 (NF-κB) Kinase & growth-factor signalling 46 docs
Matched on
NFKB1 NF-?κB NF-?kB NF-?kappaB- The Mitochondrion as Nexus (PhD Thesis)paper27
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper19
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper9
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper8
- The Vascular Phasing (PhD Thesis)paper8
- Anatomy of a Neurodegenerative Conduit — The Vagal Interfacepaper7
- Mapping the Vascular onto the Genetic Dimension (PhD)paper7
- Norepinephrine as a Two-Armed Pincer on Taupaper7
- Vascular Pathology as a Substrate Across Phasespaper7
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper5
- The Enzyme That Cuts the Protective Latticepaper4
- NAD⁺ Restoration and CD38 Inhibitionpaper3
- Restoring Autophagy in Neurodegenerationpaper3
- The Coerulean Interface — The Brainstem Origin of Alzheimer'spaper3
- Acyloxyacyl Hydrolase Neuroprotectionconcept2
- Bacterial exudate-driven neurodegenerationconcept2
- Barrier dysfunction pathologyconcept2
- GI-tract microbiome neurotoxicityconcept2
- Gut Microbiome Lipid AD Axisconcept2
- NF-kB-miRNA inflammatory cascadeconcept2
- One Sensor, Two Collapses — Which Arm Matters More?paper2
- Phase IIIpaper2
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper2
- The Bredesen ReCODE Protocol Evaluatedpaper2
- The Immunometabolic Nexus of Neurodegenerationpaper2
- The Inflammasome Versus the Reelin Brakepaper2
- The Losing Axonpaper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Autophagy as the Driver of System-Wide Agingpaper1
- Can Vaccines Protect Against Dementia?paper1
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper1
- Energy metabolism declineconcept1
- Epigenetic and genetic interplayconcept1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- Lifestyle and behavioral factorsconcept1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Multifactorial etiologyconcept1
- PARP Inhibitors and the Locus Coeruleuspaper1
- Phase IIpaper1
- The Cell Biology of the Word 'Ageing'paper1
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper1
- The Innate-Immune Sensor That Converts the Diseasepaper1
- The Load-Bearing Neuronpaper1
- The Locus Coeruleus as Phase Bridgepaper1
- The Phase II → III Transitionpaper1
DCX (doublecortin) Reelin, synapse & ECM–PNN 7 docs
Matched on
DCX doublecortin- Cortical Immature Neurons of Layer IIpaper81
- Prenatally Generated Immature Neurons and the Cellular Origin of Alzheimer's Diseasepaper33
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper14
- The Perineuronal Matrix and Cortical Layer Twopaper13
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper11
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper8
- Why Exercise Prevents but Does Not Curepaper1
MAP1LC3B (LC3) Autophagy / lysosome / clearance 31 docs
Matched on
MAP1LC3B LC3- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper38
- Autophagic Flux in Alzheimer's Diseasepaper19
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper13
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper8
- Restoring Autophagy in Neurodegenerationpaper8
- Fischer's Staged Deposit, 1907–1912paper7
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper6
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper6
- Convergent Autophagic Collapsepaper5
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper5
- Astrocytespaper4
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper4
- Autophagy as the Driver of System-Wide Agingpaper4
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper4
- The Genetic Architecture of Neurodegeneration (PhD)paper4
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper3
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper3
- The Immunometabolic Nexus of Neurodegenerationpaper3
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper2
- The Bredesen ReCODE Protocol Evaluatedpaper2
- The Mitochondrion as Nexus (PhD Thesis)paper2
- Comparing Different Viral Triggerspaper1
- Khachaturianpaper1
- Lithium in Alzheimer's Diseasepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Oxidative Stress and Autophagy Failure in Alzheimer's Diseasepaper1
- Plaque Origin What is Establishedconcept1
- Plaques Are Tombstones, Not Killerspaper1
- Ralph Nixon's Inside-Out Thesispaper1
- The Clearance Collapse — One Machinery, Three Failurespaper1
PRKN Bioenergetic / mito / NAD 28 docs
Matched on
PRKN parkin PARK2- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper27
- The Mitochondrion as Nexus (PhD Thesis)paper17
- The Genetic Architecture of Neurodegeneration (PhD)paper14
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper10
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper10
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper9
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper8
- Autophagy as the Driver of System-Wide Agingpaper7
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper7
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper5
- The Bredesen ReCODE Protocol Evaluatedpaper5
- The Narrow Gate Every Mitochondrial Protein Must Passpaper4
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper3
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper3
- The Clearance Collapse — One Machinery, Three Failurespaper3
- Comparing Different Viral Triggerspaper2
- Mapping the Vascular onto the Genetic Dimension (PhD)paper2
- Ralph Nixon's Inside-Out Thesispaper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Alzheimer's Disease — A Process in Timepaper1
- Astrocytespaper1
- cGAS–STING in Alzheimer's Diseasepaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Oxidative Stress and Autophagy Failure in Alzheimer's Diseasepaper1
- Phase IIpaper1
- Restoring Autophagy in Neurodegenerationpaper1
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper1
- The Cell Biology of the Word 'Ageing'paper1
PRNP Neurodegeneration overlap 27 docs
Matched on
PRNP prion protein PrP- Stanley Prusiner's Prion Theory and Templated Neurodegeneration, Critically Evaluatedpaper82
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper7
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper6
- Cofilin Serine 3paper5
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper5
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper5
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper4
- LRP1 and the Templated Spread of Misfolded Proteinpaper4
- Proving That Misfolded Proteins Spread Like Prionspaper3
- The Indifferent Neuronpaper3
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper2
- Can a Drug Copy the Luckiest Mutation?paper2
- Lysosomal Storage Diseaseconcept2
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper2
- The Losing Axonpaper2
- α-Synuclein Templating and Synucleinopathy Propagationpaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Cofilin Serine 3 in Alzheimer's Diseasepaper1
- Convergent Autophagic Collapsepaper1
- Different Tau Strains Cause Different Diseasespaper1
- Fischer's Eighth Stage as a Measurement of Rate Against Host Capacitypaper1
- Iron Chelation and GPX4 Stabilizationpaper1
- Seth Margolis Revisitedpaper1
- Templated Tau Misfolding Across the Three Phasespaper1
- The Strongest Case FOR the Amyloid Cascadepaper1
CLIC1 Microglia & innate immunity 1 doc
Matched on
CLIC1GRN (progranulin) Autophagy / lysosome / clearance 14 docs
Matched on
progranulin GRN- Restoring Autophagy in Neurodegenerationpaper33
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper25
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper20
- The Genetic Architecture of Neurodegeneration (PhD)paper17
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper12
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper7
- Convergent Autophagic Collapsepaper7
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper6
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper4
- Mapping the Vascular onto the Genetic Dimension (PhD)paper4
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper4
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper3
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper2
- Amyloid-β Restrains Microglia Twicepaper1
TOMM40 Bioenergetic / mito / NAD 18 docs
Matched on
TOMM40- The Narrow Gate Every Mitochondrial Protein Must Passpaper104
- TOMM40 Import Gateconcept14
- The Mitochondrion as Nexus (PhD Thesis)paper9
- Mitochondrial Dysfunctionconcept3
- APOE4 Hubnode2
- Abeta as stress response markerconcept1
- Aging as Mechanismconcept1
- Alzheimer's Disease — A Process in Timepaper1
- Anti Ferroptotic Botanicalsconcept1
- Cannabinoid Neuroprotectionconcept1
- Computational AD Subtypingconcept1
- Microglial Lipid Regulationconcept1
- Multipathology convergence theoryconcept1
- Multiple chronic stressorsconcept1
- Omics Driven Profilingconcept1
- Peripheral Lipid Biomarkersconcept1
- Presymptomatic Lipidomic Signaturesconcept1
- Systemic disease beyond CNSconcept1
LRRK2 Neurodegeneration overlap 16 docs
Matched on
LRRK2- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper41
- Convergent Autophagic Collapsepaper32
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper23
- The Genetic Architecture of Neurodegeneration (PhD)paper11
- Restoring Autophagy in Neurodegenerationpaper9
- Comparing Different Viral Triggerspaper8
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper4
- Mapping the Vascular onto the Genetic Dimension (PhD)paper3
- LRP1 and the Templated Spread of Misfolded Proteinpaper2
- Templated Tau Misfolding Across the Three Phasespaper2
- Astrocytespaper1
- Re-evaluating Höglinger's Complex I → Tau Programpaper1
- Scott Small's Retromer and Endosomal Theorypaper1
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper1
- Vascular Pathology as a Substrate Across Phasespaper1
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper1
MAOA/MAOB Neuromodulator / circadian / kynurenine 13 docs
Matched on
MAO-A MAO-B MAOA MAOB monoamine oxidase- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper35
- From Gut Ecology to the Failed Antidepressant Trialpaper32
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper29
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper15
- Tau Kindling in the Locus Coeruleuspaper13
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper5
- Khachaturianpaper2
- PARP Inhibitors and the Locus Coeruleuspaper2
- Depression as Reversible Collapsepaper1
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper1
- Templated Tau Misfolding Across the Three Phasespaper1
- The Ventral Tegmental Area in Alzheimer's Diseasepaper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
HTT (huntingtin) Neurodegeneration overlap 20 docs
Matched on
HTT huntingtin- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper39
- The Mitochondrion as Nexus (PhD Thesis)paper15
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper14
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper12
- Stanley Prusiner's Prion Theory and Templated Neurodegeneration, Critically Evaluatedpaper10
- Restoring Autophagy in Neurodegenerationpaper8
- The Genetic Architecture of Neurodegeneration (PhD)paper7
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper4
- Mapping the Vascular onto the Genetic Dimension (PhD)paper4
- Convergent Autophagic Collapsepaper3
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper2
- Lithium in Alzheimer's Diseasepaper2
- Astrocytespaper1
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper1
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper1
- LRP1 and the Templated Spread of Misfolded Proteinpaper1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- Templated Tau Misfolding Across the Three Phasespaper1
- The Glial Consortium and the Temporal Architecture of Neurodegenerationpaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
C3 Microglia & innate immunity 48 docs
Matched on
C3- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper17
- Beth Stevens's Complement-Pruning Programpaper13
- The Genetic Architecture of Neurodegeneration (PhD)paper7
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper6
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper5
- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper5
- The Losing Axonpaper5
- The Phase II → III Transitionpaper4
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper3
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper3
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper2
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper2
- Alzheimer's Disease — A Process in Timepaper2
- Antimicrobial hypothesis of amyloidconcept2
- BBB breakdown cascadeconcept2
- Circadian Immune Regulationconcept2
- Collapse, Traced Cell Type by Cell Typepaper2
- Human-germ interaction modelconcept2
- Neuroimmune Surveillanceconcept2
- Neurovascular unit as disease originconcept2
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper2
- Phase IIpaper2
- Phase IIIpaper2
- Seth Margolis Revisitedpaper2
- Shatz & Brottpaper2
- SORL1 Lysosomal Functionconcept2
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper2
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper2
- The Microglial Thesis (Downloadable PDF)paper2
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper1
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper1
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper1
- Down Syndrome as the Disease Run in Fast-Forwardpaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Microglial Restraint as Resiliencepaper1
- Neuroimmune Interfacenode1
- Neuroinflammationconcept1
- Ordered Attrition and Resilience as the Two Human-Evidence Anchors of Alzheimer'spaper1
- Plaques Are Tombstones, Not Killerspaper1
- Sleep as the Shared Off-Line State of Every Collapse Axispaper1
- Synaptic Pathologyconcept1
- The Cell Biology of the Word 'Ageing'paper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The Synaptic Thesis (Downloadable PDF)paper1
- Todd Golde's Amyloid Cascade, Read for What It Addspaper1
NGF Trophic / exercise / resilience 18 docs
Matched on
nerve growth factor NGF- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper43
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper22
- The Indifferent Neuronpaper11
- The Pedunculopontine Nucleus in Alzheimer's Diseasepaper8
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper7
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper7
- Collapse, Traced Cell Type by Cell Typepaper6
- Down Syndrome as the Disease Run in Fast-Forwardpaper4
- BDNF and the Trophic Failure of the Synapse in Alzheimer's Diseasepaper3
- Restoring Autophagy in Neurodegenerationpaper3
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper2
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper2
- Brain hemisphere synchronizationconcept1
- Dietary neuroprotectionconcept1
- Lifestyle intervention for neurodegenerationconcept1
- Non-pharmacological cognitive enhancementconcept1
- The Bredesen ReCODE Protocol Evaluatedpaper1
GFAP Astrocyte & glial markers 26 docs
Matched on
GFAP- The Biomarker Cascade (PhD Thesis)paper54
- Telling Different Dementias Apartpaper19
- Mapping the Vascular onto the Genetic Dimension (PhD)paper7
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper6
- Collapse, Traced Cell Type by Cell Typepaper4
- Fischer's Staged Deposit, 1907–1912paper4
- Oskar Fischer's Eight Stages of Plaque Formationpaper3
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper2
- Microglial Restraint as Resiliencepaper2
- The Genetic Architecture of Neurodegeneration (PhD)paper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- Astrocytespaper1
- Autophagic Flux in Alzheimer's Diseasepaper1
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper1
- Cellular Senescenceconcept1
- Fischer's Eighth Stage as a Measurement of Rate Against Host Capacitypaper1
- Fischer's Sixth Stage and the Leptomeningeal Compartment It Never Enteredpaper1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- Phase IIpaper1
- Plaques Are Tombstones, Not Killerspaper1
- Standard Diagnostic Biomarkers Explainedpaper1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Plaque Was Staged Before It Was Countedpaper1
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper1
- The Vascular Phasing (PhD Thesis)paper1
AKT1 (Akt) Kinase & growth-factor signalling 51 docs
Matched on
AKT1 Akt- Lithium in Alzheimer's Diseasepaper16
- Norepinephrine as a Two-Armed Pincer on Taupaper10
- Metabolic-Homeostatic Axisnode6
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper5
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper4
- Can a Drug Copy the Luckiest Mutation?paper4
- The Mitochondrion as Nexus (PhD Thesis)paper4
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper3
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper3
- The Bredesen ReCODE Protocol Evaluatedpaper3
- The Enzyme That Cuts the Protective Latticepaper3
- The Immunometabolic Nexus of Neurodegenerationpaper3
- The Losing Axonpaper3
- Bioenergeticsconcept2
- Can Vaccines Protect Against Dementia?paper2
- Cofilin Serine 3paper2
- Comparing Different Viral Triggerspaper2
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper2
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper2
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper2
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper2
- Tau Kindling in the Locus Coeruleuspaper2
- The Brain's Architect and the Brake It Puts on Taupaper2
- The Indifferent Neuronpaper2
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Amyloid-β Restrains Microglia Twicepaper1
- BDNF and the Trophic Failure of the Synapse in Alzheimer's Diseasepaper1
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper1
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper1
- Depression as Reversible Collapsepaper1
- Endolysosomal Dysfunctionconcept1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Microglial Immunometabolismconcept1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper1
- One Sugar Lattice, Three Jobspaper1
- Synaptic Competitionconcept1
- Synaptic Pathologyconcept1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Biomarker Cascade (PhD Thesis)paper1
- The Inflammasome Versus the Reelin Brakepaper1
- The Microglial Thesis (Downloadable PDF)paper1
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper1
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
- Vaccines That May Prevent Dementiapaper1
- Zhen Huang's Competitive Synaptic Plasticity and the Amyloid-β Monomer Depletion Modelpaper1
MME (neprilysin) Amyloid & Tau core 24 docs
Matched on
MME neprilysin- The Somatostatin Interneuron in Alzheimer's Diseasepaper40
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper17
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper11
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper7
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper7
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper7
- Collapse, Traced Cell Type by Cell Typepaper5
- Why Exercise Prevents but Does Not Curepaper4
- Wandering in Alzheimer's Diseasepaper3
- Aluminum as primary environmental causeconcept1
- Aluminum driving amyloid productionconcept1
- Environmental toxicology of neurodegenerationconcept1
- Exponential exposure-prevalence correlationconcept1
- Fischer's Staged Deposit, 1907–1912paper1
- Glymphatic Clearance Failure in Alzheimer's Disease and the Noradrenergic Switchpaper1
- Gouraspaper1
- LRP1 and the Templated Spread of Misfolded Proteinpaper1
- Mercury as primary AD causeconcept1
- Metal-protein interaction in diseaseconcept1
- Neurotransmitter disruption cascadeconcept1
- Restoring Autophagy in Neurodegenerationpaper1
- Silica water as protective interventionconcept1
- The Load-Bearing Neuronpaper1
- The Losing Axonpaper1
VLDLR Reelin, synapse & ECM–PNN 32 docs
Matched on
VLDLR- Can a Drug Copy the Luckiest Mutation?paper16
- The Enzyme That Cuts the Protective Latticepaper16
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper9
- Norepinephrine as a Two-Armed Pincer on Taupaper8
- The Brain's Architect and the Brake It Puts on Taupaper8
- The Load-Bearing Neuronpaper6
- The Inflammasome Versus the Reelin Brakepaper5
- Tau Kindling in the Locus Coeruleuspaper4
- LRP1 and the Templated Spread of Misfolded Proteinpaper3
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper3
- Reelin-ApoE receptor axis disruptionconcept3
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper3
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper3
- APOE4 Hubnode2
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper2
- Cofilin Serine 3paper2
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper2
- One Sugar Lattice, Three Jobspaper2
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper1
- From Gut Ecology to the Failed Antidepressant Trialpaper1
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper1
- Perineuronal Netsconcept1
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper1
- The Genes That Protect — Phenocopy the Fortunatepaper1
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper1
- The Somatostatin Interneuron in Alzheimer's Diseasepaper1
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper1
C9ORF72 Neurodegeneration overlap 11 docs
Matched on
C9ORF72- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper23
- The Genetic Architecture of Neurodegeneration (PhD)paper16
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper14
- Restoring Autophagy in Neurodegenerationpaper13
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper12
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper7
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper6
- Mapping the Vascular onto the Genetic Dimension (PhD)paper5
- Convergent Autophagic Collapsepaper2
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
- The Glial Consortium and the Temporal Architecture of Neurodegenerationpaper1
CASP1 Microglia & innate immunity 23 docs
Matched on
CASP1 caspase[- ]?1- The Innate-Immune Sensor That Converts the Diseasepaper30
- The Inflammasome Versus the Reelin Brakepaper18
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper11
- One Sensor, Two Collapses — Which Arm Matters More?paper9
- The Microglion That Silences Tau's Phosphatasepaper4
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper3
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper3
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper2
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper2
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Alzheimer's Disease — A Process in Timepaper1
- Autophagy as the Driver of System-Wide Agingpaper1
- Depression as Reversible Collapsepaper1
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The Phase II → III Transitionpaper1
GBA Neurodegeneration overlap 15 docs
Matched on
GBA1 GBA- Convergent Autophagic Collapsepaper19
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper17
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper16
- The Genetic Architecture of Neurodegeneration (PhD)paper14
- Restoring Autophagy in Neurodegenerationpaper10
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper6
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper4
- Comparing Different Viral Triggerspaper3
- Mapping the Vascular onto the Genetic Dimension (PhD)paper3
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper2
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper1
- Stanley Prusiner's Prion Theory and Templated Neurodegeneration, Critically Evaluatedpaper1
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper1
NEFL (NfL) Reelin, synapse & ECM–PNN 21 docs
Matched on
NEFL neurofilament light NfL- The Biomarker Cascade (PhD Thesis)paper45
- Autophagic Flux in Alzheimer's Diseasepaper13
- Telling Different Dementias Apartpaper12
- Choline, Phosphatidylcholine and APOE4 in Alzheimer's Diseasepaper3
- Phase IIpaper3
- Standard Diagnostic Biomarkers Explainedpaper3
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper2
- Pavel Kalvach's Case That Alzheimer's Is Not a Disease, Gradedpaper2
- Templated Tau Misfolding Across the Three Phasespaper2
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper2
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper1
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper1
- Depression as Reversible Collapsepaper1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper1
- Restoring Autophagy in Neurodegenerationpaper1
- Stanley Prusiner's Prion Theory and Templated Neurodegeneration, Critically Evaluatedpaper1
- The Brain's Border Gatepaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
- The Indifferent Neuronpaper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
MMP2 Reelin, synapse & ECM–PNN 33 docs
Matched on
MMP-?2- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper25
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper9
- Phase IIIpaper8
- The Genetic Architecture of Neurodegeneration (PhD)paper4
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper3
- Amyloid-β Restrains Microglia Twicepaper3
- Cellular Senescenceconcept3
- The Enzyme That Cuts the Protective Latticepaper3
- The Microglial Thesis (Downloadable PDF)paper3
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper2
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper2
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper2
- One Sugar Lattice, Three Jobspaper2
- Perineuronal Netsconcept2
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper2
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper2
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- AD as accelerated aging of Abeta managementconcept1
- Aging accelerators and deceleratorsconcept1
- Clearance failure vs. overproductionconcept1
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
- Fischer's Matrixpaper1
- Inflamm-aging as disease driverconcept1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Norepinephrine as a Two-Armed Pincer on Taupaper1
- Oskar Fischer's Eight Stages of Plaque Formationpaper1
- Re-evaluating Tsai's 40 Hz Gamma Programpaper1
- The Cell Biology of the Word 'Ageing'paper1
- The Losing Axonpaper1
- The Phase II → III Transitionpaper1
- The Vascular Phasing (PhD Thesis)paper1
BCAN (brevican) Reelin, synapse & ECM–PNN 31 docs
Matched on
BCAN brevican- The Phase II → III Transitionpaper12
- The Genetic Architecture of Neurodegeneration (PhD)paper8
- Phase IIIpaper7
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper6
- The Enzyme That Cuts the Protective Latticepaper5
- Norepinephrine as a Two-Armed Pincer on Taupaper4
- Collapse, Traced Cell Type by Cell Typepaper3
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper3
- Perineuronal Netsconcept3
- The Matrix as the Seventh Axis of Collapsepaper3
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper3
- The Perineuronal Matrix and Cortical Layer Twopaper3
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper3
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper2
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper2
- Depression as Reversible Collapsepaper2
- Down Syndrome as the Disease Run in Fast-Forwardpaper2
- Fischer's Matrixpaper2
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper2
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper2
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper2
- The Proteolytic Degradation of the Perineuronal Net and the Loss of PV Interneuronspaper2
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper1
- Alzheimer's Disease as a Fifty-Year Process in Time and Spacepaper1
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The Cell Biology of the Word 'Ageing'paper1
- The Load-Bearing Neuronpaper1
- The Locus Coeruleus as Phase Bridgepaper1
SNCA Neurodegeneration overlap 26 docs
Matched on
SNCA α-synuclein alpha-synuclein α-syn- The Mitochondrion as Nexus (PhD Thesis)paper23
- The Genetic Architecture of Neurodegeneration (PhD)paper14
- α-Synuclein Templating and Synucleinopathy Propagationpaper13
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper6
- The Glial Consortium and the Temporal Architecture of Neurodegenerationpaper4
- Mapping the Vascular onto the Genetic Dimension (PhD)paper3
- Proving That Misfolded Proteins Spread Like Prionspaper3
- Restoring Autophagy in Neurodegenerationpaper3
- cGAS–STING in Alzheimer's Diseasepaper2
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper2
- The Gut Ecosystem as the Upstream Originpaper2
- Astrocytespaper1
- Different Tau Strains Cause Different Diseasespaper1
- Estela Area-Gómez's MAM Theorypaper1
- From Gut Ecology to the Failed Antidepressant Trialpaper1
- Infectious etiology of ADconcept1
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper1
- P. gingivalis as keystone pathogenconcept1
- PARP Inhibitors and the Locus Coeruleuspaper1
- Phase IIIpaper1
- Polymicrobial brain infectionconcept1
- Standard Diagnostic Biomarkers Explainedpaper1
- Stanley Prusiner's Prion Theory and Templated Neurodegeneration, Critically Evaluatedpaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
- The Narrow Gate Every Mitochondrial Protein Must Passpaper1
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper1
TOM40 Bioenergetic / mito / NAD 9 docs
Matched on
TOM40- The Narrow Gate Every Mitochondrial Protein Must Passpaper53
- The Mitochondrion as Nexus (PhD Thesis)paper16
- TOMM40 Import Gateconcept5
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper4
- The Clearance Collapse — One Machinery, Three Failurespaper4
- Alzheimer's Disease — A Process in Timepaper3
- Collapse, Traced Cell Type by Cell Typepaper1
- Mitochondrial Dysfunctionconcept1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
CR3 Microglia & innate immunity 35 docs
Matched on
CR3 CD11b ITGAM- Beth Stevens's Complement-Pruning Programpaper12
- The Phase II → III Transitionpaper8
- The Genetic Architecture of Neurodegeneration (PhD)paper6
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper5
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper4
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper3
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper3
- Shatz & Brottpaper3
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper2
- Antimicrobial hypothesis of amyloidconcept2
- BBB breakdown cascadeconcept2
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper2
- Circadian Immune Regulationconcept2
- Collapse, Traced Cell Type by Cell Typepaper2
- Human-germ interaction modelconcept2
- Neuroimmune Surveillanceconcept2
- Neurovascular unit as disease originconcept2
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper2
- Phase IIIpaper2
- Seth Margolis Revisitedpaper2
- SORL1 Lysosomal Functionconcept2
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper2
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper2
- The Microglial Thesis (Downloadable PDF)paper2
- Alzheimer's Disease — A Process in Timepaper1
- Amyloid-β Restrains Microglia Twicepaper1
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper1
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper1
- Down Syndrome as the Disease Run in Fast-Forwardpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Neuroimmune Interfacenode1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- Phase IIpaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Synaptic Thesis (Downloadable PDF)paper1
RAB5A Autophagy / lysosome / clearance 16 docs
Matched on
RAB5A Rab5- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper33
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper10
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper10
- Scott Small's Retromer and Endosomal Theorypaper10
- Fischer's Staged Deposit, 1907–1912paper4
- Autophagic Flux in Alzheimer's Diseasepaper3
- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper3
- Down Syndrome as the Disease Run in Fast-Forwardpaper2
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper1
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper1
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper1
- Cofilin Serine 3paper1
- Endosomal Nexusnode1
- Endosomal Traffickingconcept1
- Restoring Autophagy in Neurodegenerationpaper1
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper1
NTRK2 (TrkB) Trophic / exercise / resilience 19 docs
Matched on
NTRK2 TrkB- BDNF and the Trophic Failure of the Synapse in Alzheimer's Diseasepaper31
- The Indifferent Neuronpaper16
- Depression as Reversible Collapsepaper6
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper4
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper4
- Can a Drug Copy the Luckiest Mutation?paper3
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper2
- Synaptic Plasticityconcept2
- When the Gut Writes the First Depressionpaper2
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper1
- cognitive resilienceconcept1
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper1
- From Gut Ecology to the Failed Antidepressant Trialpaper1
- Lithium in Alzheimer's Diseasepaper1
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper1
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper1
- Structural Instructions at the Synapse Are Terminated by Destruction, Not Dephosphorylationpaper1
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
HIF1A Bioenergetic / mito / NAD 6 docs
Matched on
HIF1A HIF-?1- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper70
- BCG Vaccination in Alzheimer's Diseasepaper5
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper1
- Telling Different Dementias Apartpaper1
- Vaccines That May Prevent Dementiapaper1
BIN1 GWAS / LOAD risk 25 docs
Matched on
BIN1- The Clearance Collapse — One Machinery, Three Failurespaper13
- The Genetic Architecture of Neurodegeneration (PhD)paper12
- BIN1 Autophagic Regulationconcept6
- Age-dependent feedback loops in neurodegenerationconcept4
- AI Neurotherapeutic Discoveryconcept4
- ESCRT III Membrane Scissionconcept4
- Onset vs Progressionconcept4
- Proteasome Tau Feedbackconcept4
- Quality Control Collapseconcept4
- Beth Stevens's Complement-Pruning Programpaper3
- Mapping the Vascular onto the Genetic Dimension (PhD)paper3
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper2
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper2
- The Mitochondrion as Nexus (PhD Thesis)paper2
- Alzheimer's Disease — A Process in Timepaper1
- Autophagyconcept1
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper1
- Endosomal Traffickingconcept1
- Moosmann & Sohrepaper1
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper1
- Rappoportpaper1
- Scott Small's Retromer and Endosomal Theorypaper1
- Smallpaper1
- Templated Tau Misfolding Across the Three Phasespaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
TNR (tenascin-R) Reelin, synapse & ECM–PNN 33 docs
Matched on
tenascin-?R TNR- Fischer's Matrixpaper8
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper7
- Perineuronal Netsconcept5
- Phase IIIpaper5
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper5
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper4
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper3
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper3
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper3
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- The Matrix as the Seventh Axis of Collapsepaper3
- The Microglial Thesis (Downloadable PDF)paper3
- cognitive resilienceconcept2
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper2
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper2
- The Mitochondrion as Nexus (PhD Thesis)paper2
- The Proteolytic Degradation of the Perineuronal Net and the Loss of PV Interneuronspaper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Can a Drug Copy the Luckiest Mutation?paper1
- Collapse, Traced Cell Type by Cell Typepaper1
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- One Sensor, Two Collapses — Which Arm Matters More?paper1
- One Sugar Lattice, Three Jobspaper1
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper1
- Templated Tau Misfolding Across the Three Phasespaper1
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper1
- The Enzyme That Cuts the Protective Latticepaper1
- The Load-Bearing Neuronpaper1
- The Plaque Was Staged Before It Was Countedpaper1
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper1
PLCG2 GWAS / LOAD risk 16 docs
Matched on
PLCG2- The Genes That Protect — Phenocopy the Fortunatepaper17
- The Genetic Architecture of Neurodegeneration (PhD)paper16
- Amyloid-β Restrains Microglia Twicepaper12
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper7
- Microglial Restraint as Resiliencepaper7
- The Losing Axonpaper4
- Todd Golde's Amyloid Cascade, Read for What It Addspaper3
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper2
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Chronobiologic neuroprotection via melatoninconcept1
- Cognitive resilience as dynamic protective conceptconcept1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Multifactorial prevention through modifiable risk factorsconcept1
- Population-specific AD genetic signaturesconcept1
- The Innate-Immune Sensor That Converts the Diseasepaper1
- The Microglial Thesis (Downloadable PDF)paper1
BECN1 Autophagy / lysosome / clearance 20 docs
Matched on
BECN1 Beclin- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper16
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper15
- Comparing Different Viral Triggerspaper8
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper6
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper4
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper4
- Restoring Autophagy in Neurodegenerationpaper3
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper3
- Can Vaccines Protect Against Dementia?paper2
- Viral Pathogenesisconcept2
- APOE4 Pathogen Interactionconcept1
- Autophagyconcept1
- cGAS–STING in Alzheimer's Diseasepaper1
- Convergent Autophagic Collapsepaper1
- Gene Environment Interactionconcept1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Clearance Collapse — One Machinery, Three Failurespaper1
- Trauma Induced Viral Reactivationconcept1
SOD1 Oxidative stress & ferroptosis 20 docs
Matched on
SOD1- Proving That Misfolded Proteins Spread Like Prionspaper13
- Restoring Autophagy in Neurodegenerationpaper10
- The Genetic Architecture of Neurodegeneration (PhD)paper10
- Down Syndrome as the Disease Run in Fast-Forwardpaper8
- The Indifferent Neuronpaper8
- Stanley Prusiner's Prion Theory and Templated Neurodegeneration, Critically Evaluatedpaper7
- Mapping the Vascular onto the Genetic Dimension (PhD)paper3
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper2
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper2
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper1
- LRP1 and the Templated Spread of Misfolded Proteinpaper1
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper1
- Smallpaper1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- The Glial Consortium and the Temporal Architecture of Neurodegenerationpaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
TREX1 Vascular / BBB 7 docs
Matched on
TREX1- Asparaginyl Endopeptidase in the Locus Coeruleuspaper31
- Mapping the Vascular onto the Genetic Dimension (PhD)paper14
- cGAS–STING in Alzheimer's Diseasepaper9
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper9
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper7
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper3
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper2
PPP2R2A (B55α) Kinase & growth-factor signalling 5 docs
Matched on
PPP2R2A B55- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper50
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper21
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Cofilin Serine 3paper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
P2RY12 Microglia & innate immunity 35 docs
Matched on
P2RY12 P2Y12- The Microglion That Silences Tau's Phosphatasepaper9
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper7
- The Microglial Thesis (Downloadable PDF)paper7
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper4
- The Genetic Architecture of Neurodegeneration (PhD)paper4
- BCG Vaccination in Alzheimer's Diseasepaper3
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper3
- The Losing Axonpaper3
- Collapse, Traced Cell Type by Cell Typepaper2
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper2
- Down Syndrome as the Disease Run in Fast-Forwardpaper2
- Fischer's Staged Deposit, 1907–1912paper2
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper2
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Alzheimer's Disease — A Process in Timepaper1
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper1
- Depression as Reversible Collapsepaper1
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Homeostatic Microglial Collapseconcept1
- Iron Chelation and GPX4 Stabilizationpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Microglial Restraint as Resiliencepaper1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- Oskar Fischer's Eight Stages of Plaque Formationpaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The Plaque Was Staged Before It Was Countedpaper1
- The Vascular Phasing (PhD Thesis)paper1
NFE2L2 (NRF2) Oxidative stress & ferroptosis 14 docs
Matched on
NFE2L2 NRF2- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper22
- Phase IIpaper20
- The Bredesen ReCODE Protocol Evaluatedpaper8
- The Genetic Architecture of Neurodegeneration (PhD)paper6
- The Mitochondrion as Nexus (PhD Thesis)paper3
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper2
- Mapping the Vascular onto the Genetic Dimension (PhD)paper2
- NAD⁺ Restoration and CD38 Inhibitionpaper2
- Oxidative Stressconcept2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Iron Chelation and GPX4 Stabilizationpaper1
- Lithium in Alzheimer's Diseasepaper1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper1
UBE3A Autophagy / lysosome / clearance 12 docs
Matched on
UBE3A- Cofilin Serine 3paper14
- Seth Margolis Revisitedpaper12
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper10
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper7
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper6
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper6
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper6
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper4
- Margolispaper3
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper2
- Structural Instructions at the Synapse Are Terminated by Destruction, Not Dephosphorylationpaper1
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper1
CD33 GWAS / LOAD risk 19 docs
Matched on
CD33- The Genes That Protect — Phenocopy the Fortunatepaper18
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper14
- The Genetic Architecture of Neurodegeneration (PhD)paper12
- The Innate-Immune Sensor That Converts the Diseasepaper4
- Restoring Autophagy in Neurodegenerationpaper3
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper2
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper2
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper2
- Mapping the Vascular onto the Genetic Dimension (PhD)paper2
- Microglial Restraint as Resiliencepaper2
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Different Tau Strains Cause Different Diseasespaper1
- Shatz & Brottpaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
- The Losing Axonpaper1
- The Microglial Thesis (Downloadable PDF)paper1
- Vaccines That May Prevent Dementiapaper1
- Zhen Huang's Competitive Synaptic Plasticity and the Amyloid-β Monomer Depletion Modelpaper1
PRKAA (AMPK) Bioenergetic / mito / NAD 22 docs
Matched on
AMPK PRKAA1 PRKAA2- Restoring Autophagy in Neurodegenerationpaper12
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper8
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper6
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper5
- Autophagic Flux in Alzheimer's Diseasepaper5
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper5
- Autophagy as the Driver of System-Wide Agingpaper4
- Depression as Reversible Collapsepaper4
- The Clearance Collapse — One Machinery, Three Failurespaper4
- The Bredesen ReCODE Protocol Evaluatedpaper3
- NAD⁺ Restoration and CD38 Inhibitionpaper2
- The Mitochondrion as Nexus (PhD Thesis)paper2
- Anne Eckert's Neuroendocrine Theory and the Withdrawal of Protection in the Ageing Brainpaper1
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper1
- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper1
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper1
- Iron Chelation and GPX4 Stabilizationpaper1
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper1
PIK3CA (PI3K) Kinase & growth-factor signalling 41 docs
Matched on
PIK3CA PI3-?kinase PI3K- Metabolic-Homeostatic Axisnode6
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper5
- The Mitochondrion as Nexus (PhD Thesis)paper4
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper3
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper3
- The Bredesen ReCODE Protocol Evaluatedpaper3
- The Load-Bearing Neuronpaper3
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Bioenergeticsconcept2
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper2
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper2
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper2
- The Brain's Architect and the Brake It Puts on Taupaper2
- The Genetic Architecture of Neurodegeneration (PhD)paper2
- The Losing Axonpaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Can Vaccines Protect Against Dementia?paper1
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper1
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper1
- Cofilin Serine 3 in Alzheimer's Diseasepaper1
- Cofilin Serine 3paper1
- Comparing Different Viral Triggerspaper1
- Depression as Reversible Collapsepaper1
- Endolysosomal Dysfunctionconcept1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Microglial Immunometabolismconcept1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper1
- One Sugar Lattice, Three Jobspaper1
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper1
- Synaptic Competitionconcept1
- Synaptic Pathologyconcept1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Biomarker Cascade (PhD Thesis)paper1
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Microglial Thesis (Downloadable PDF)paper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
- Zhen Huang's Competitive Synaptic Plasticity and the Amyloid-β Monomer Depletion Modelpaper1
SIRT1 Bioenergetic / mito / NAD 23 docs
Matched on
SIRT1- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper14
- NAD⁺ Restoration and CD38 Inhibitionpaper8
- The Genes That Protect — Phenocopy the Fortunatepaper6
- PARP Inhibitors and the Locus Coeruleuspaper5
- SIRT1 neuroprotectionconcept5
- The Genetic Architecture of Neurodegeneration (PhD)paper5
- Ayurvedic medicine approachconcept3
- Curcumin multi-target actionconcept3
- Natural product polytherapyconcept3
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper2
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper2
- The Mitochondrion as Nexus (PhD Thesis)paper2
- Autophagyconcept1
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper1
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
- Endolysosomal Dysfunctionconcept1
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper1
- Epigenetic Repressionconcept1
- Restoring Autophagy in Neurodegenerationpaper1
- Selective Tau Disruptionconcept1
- Tau Scaffolding Interactionsconcept1
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper1
- Vesicular Traffickingconcept1
AQP4 Vascular / BBB 6 docs
Matched on
AQP4- Glymphatic Clearance Failure in Alzheimer's Disease and the Noradrenergic Switchpaper30
- Mapping the Vascular onto the Genetic Dimension (PhD)paper18
- Vascular Pathology as a Substrate Across Phasespaper9
- The Vascular Phasing (PhD Thesis)paper7
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper2
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
CX3CR1 Microglia & innate immunity 29 docs
Matched on
CX3CR1- The Brakes on Microglial Activation in Alzheimer's Diseasepaper8
- The Microglion That Silences Tau's Phosphatasepaper7
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper6
- The Microglial Thesis (Downloadable PDF)paper6
- The Genetic Architecture of Neurodegeneration (PhD)paper4
- Amyloid-β Restrains Microglia Twicepaper3
- Alzheimer's Disease — A Process in Timepaper2
- BCG Vaccination in Alzheimer's Diseasepaper2
- Collapse, Traced Cell Type by Cell Typepaper2
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper2
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper2
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper2
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper2
- The Locus Coeruleus as Phase Bridgepaper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- Down Syndrome as the Disease Run in Fast-Forwardpaper1
- Homeostatic Microglial Collapseconcept1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Microglial Restraint as Resiliencepaper1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- Templated Tau Misfolding Across the Three Phasespaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
- The Losing Axonpaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The Vascular Phasing (PhD Thesis)paper1
FTH1/FTL (ferritin) Oxidative stress & ferroptosis 18 docs
Matched on
ferritin FTH1 FTL- Iron Chelation and GPX4 Stabilizationpaper19
- Phase IIpaper14
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper3
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper3
- The Immunometabolic Nexus of Neurodegenerationpaper3
- The Microglial Thesis (Downloadable PDF)paper3
- The Phase II → III Transitionpaper3
- Cellular Senescenceconcept2
- Collapse, Traced Cell Type by Cell Typepaper2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- The Bredesen ReCODE Protocol Evaluatedpaper2
- The Cell Biology of the Word 'Ageing'paper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Phase IIIpaper1
- Ralph Nixon's Inside-Out Thesispaper1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
MAPK14 (p38) Kinase & growth-factor signalling 11 docs
Matched on
MAPK14 p38- The Somatostatin Interneuron in Alzheimer's Diseasepaper41
- Autophagic Flux in Alzheimer's Diseasepaper4
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper4
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper4
- The Microglion That Silences Tau's Phosphatasepaper4
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- Plaques Are Tombstones, Not Killerspaper1
- The Losing Axonpaper1
CSF1R Microglia & innate immunity 21 docs
Matched on
CSF1R- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper7
- Phase IIIpaper7
- The Microglial Thesis (Downloadable PDF)paper7
- Amyloid-β Restrains Microglia Twicepaper6
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper6
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper4
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper4
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper3
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper3
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper2
- Oskar Fischer's Eight Stages of Plaque Formationpaper2
- Perineuronal Netsconcept2
- The Plaque Was Staged Before It Was Countedpaper2
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper1
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Fischer's Matrixpaper1
- Templated Tau Misfolding Across the Three Phasespaper1
- The Losing Axonpaper1
- The Phase II → III Transitionpaper1
AIFM2 (FSP1) Oxidative stress & ferroptosis 4 docs
Matched on
FSP1 AIFM2CTSD Autophagy / lysosome / clearance 21 docs
Matched on
CTSD cathepsin D- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper10
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper5
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper5
- Plaques Are Tombstones, Not Killerspaper5
- Fischer's Staged Deposit, 1907–1912paper4
- Ralph Nixon's Inside-Out Thesispaper4
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper4
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper3
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper3
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper3
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper2
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper2
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper2
- Convergent Autophagic Collapsepaper2
- The Microglial Thesis (Downloadable PDF)paper2
- Collapse, Traced Cell Type by Cell Typepaper1
- Comparing Different Viral Triggerspaper1
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper1
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper1
- Restoring Autophagy in Neurodegenerationpaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
FNDC5 (irisin) Trophic / exercise / resilience 4 docs
Matched on
FNDC5 irisinIL6 Microglia & innate immunity 28 docs
Matched on
IL-?6- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper14
- The Losing Axonpaper7
- Cellular Senescenceconcept4
- Amyloid-β Restrains Microglia Twicepaper3
- Depression as Reversible Collapsepaper3
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper3
- The Immunometabolic Nexus of Neurodegenerationpaper3
- BCG Vaccination in Alzheimer's Diseasepaper2
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper2
- The Vascular Phasing (PhD Thesis)paper2
- Vascular Pathology as a Substrate Across Phasespaper2
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Autophagy as the Driver of System-Wide Agingpaper1
- Beth Stevens's Complement-Pruning Programpaper1
- Can Vaccines Protect Against Dementia?paper1
- Lithium in Alzheimer's Diseasepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- Neurotropic Viral Invasion of the Central Nervous Systempaper1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper1
- Restoring Autophagy in Neurodegenerationpaper1
- Telling Different Dementias Apartpaper1
- The Biomarker Cascade (PhD Thesis)paper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
- Zhen Huang's Competitive Synaptic Plasticity and the Amyloid-β Monomer Depletion Modelpaper1
CTSB Autophagy / lysosome / clearance 19 docs
Matched on
CTSB cathepsin B- Why Exercise Prevents but Does Not Curepaper15
- The Innate-Immune Sensor That Converts the Diseasepaper10
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper6
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper4
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper3
- One Sensor, Two Collapses — Which Arm Matters More?paper3
- The Microglial Thesis (Downloadable PDF)paper3
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper2
- Convergent Autophagic Collapsepaper2
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper2
- Templated Tau Misfolding Across the Three Phasespaper2
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper2
- Autophagic Flux in Alzheimer's Diseasepaper1
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper1
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper1
- Ralph Nixon's Inside-Out Thesispaper1
- The Inflammasome Versus the Reelin Brakepaper1
PSEN2 Amyloid & Tau core 34 docs
Matched on
PSEN2 PS2 presenilin[- ]?2- Estela Area-Gómez's MAM Theorypaper9
- The Genetic Architecture of Neurodegeneration (PhD)paper6
- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper5
- Pavel Kalvach's Case That Alzheimer's Is Not a Disease, Gradedpaper3
- Todd Golde's Amyloid Cascade, Read for What It Addspaper3
- Anne Eckert's Neuroendocrine Theory and the Withdrawal of Protection in the Ageing Brainpaper2
- Convergent Autophagic Collapsepaper2
- Mapping the Vascular onto the Genetic Dimension (PhD)paper2
- Standard Diagnostic Biomarkers Explainedpaper2
- The Strongest Case FOR the Amyloid Cascadepaper2
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Amyloid-β Restrains Microglia Twicepaper1
- APP and tau pathology linked through transport disruptionconcept1
- Autophagic Flux in Alzheimer's Diseasepaper1
- Autophagy-lysosomal failureconcept1
- Axonal transport failure as unifying mechanismconcept1
- Cofilin Serine 3paper1
- Dynamic and region-independent disease mechanismsconcept1
- Epigenetic regulation of AD genesconcept1
- Fischer's Staged Deposit, 1907–1912paper1
- Gene dosage of APP directly causes pathogenesisconcept1
- Gut-brain axis in neuroinflammationconcept1
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper1
- Multi-pathway AD pathophysiology reviewconcept1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper1
- Re-evaluating Tsai's 40 Hz Gamma Programpaper1
- Scott Small's Retromer and Endosomal Theorypaper1
- Smallpaper1
- Solomon Carter Fuller's 1911 Plaque Audit, Read Beside Oskar Fischer'spaper1
- The Calcium Hypothesis and the Systems Failure Model of Alzheimer's Diseasepaper1
- The Genes That Protect — Phenocopy the Fortunatepaper1
- The Losing Axonpaper1
SYK Microglia & innate immunity 12 docs
Matched on
SYK- Amyloid-β Restrains Microglia Twicepaper40
- The Losing Axonpaper9
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper2
- The Microglial Thesis (Downloadable PDF)paper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- Metabolic-Homeostatic Axisnode1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
CLDN5 Vascular / BBB 6 docs
Matched on
CLDN5 claudin-?5- Mapping the Vascular onto the Genetic Dimension (PhD)paper38
- Vascular Pathology as a Substrate Across Phasespaper7
- The Vascular Phasing (PhD Thesis)paper5
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper4
- The Immunometabolic Nexus of Neurodegenerationpaper4
- The Brain's Border Gatepaper2
GSDMD Microglia & innate immunity 9 docs
Matched on
GSDMD gasdermin- The Inflammasome Versus the Reelin Brakepaper22
- The Innate-Immune Sensor That Converts the Diseasepaper21
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper6
- One Sensor, Two Collapses — Which Arm Matters More?paper3
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper2
- Depression as Reversible Collapsepaper1
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper1
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper1
KMO Neuromodulator / circadian / kynurenine 6 docs
Matched on
KMO- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper37
- Depression as Reversible Collapsepaper8
- From Gut Ecology to the Failed Antidepressant Trialpaper8
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper2
- The Biomarker Cascade (PhD Thesis)paper2
- The Genetic Architecture of Neurodegeneration (PhD)paper2
PPP3CA (calcineurin) Kinase & growth-factor signalling 21 docs
Matched on
PPP3CA calcineurin- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper16
- The Load-Bearing Neuronpaper15
- Down Syndrome as the Disease Run in Fast-Forwardpaper2
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper2
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper2
- Restoring Autophagy in Neurodegenerationpaper2
- The Bredesen ReCODE Protocol Evaluatedpaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper1
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- BDNF and the Trophic Failure of the Synapse in Alzheimer's Diseasepaper1
- cGAS–STING in Alzheimer's Diseasepaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- Ralph Nixon's Inside-Out Thesispaper1
- The Calcium Hypothesis and the Systems Failure Model of Alzheimer's Diseasepaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
SRC Kinase & growth-factor signalling 19 docs
Matched on
Src[- ]family Src kinases?- Can a Drug Copy the Luckiest Mutation?paper6
- Cofilin Serine 3paper6
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper5
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper5
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper4
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper4
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper3
- The Load-Bearing Neuronpaper3
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper2
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper2
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper2
- The Brain's Architect and the Brake It Puts on Taupaper2
- The Inflammasome Versus the Reelin Brakepaper2
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper2
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper1
- Cofilin Serine 3 in Alzheimer's Diseasepaper1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- Seth Margolis Revisitedpaper1
- The Enzyme That Cuts the Protective Latticepaper1
ADAMTS4 Reelin, synapse & ECM–PNN 24 docs
Matched on
ADAMTS-?4- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper8
- Fischer's Matrixpaper5
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper5
- The Genetic Architecture of Neurodegeneration (PhD)paper5
- Can a Drug Copy the Luckiest Mutation?paper3
- The Phase II → III Transitionpaper3
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper2
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper2
- Down Syndrome as the Disease Run in Fast-Forwardpaper2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- One Sensor, Two Collapses — Which Arm Matters More?paper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Alzheimer's Disease — A Process in Timepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Oskar Fischer's Eight Stages of Plaque Formationpaper1
- Perineuronal Netsconcept1
- Phase IIIpaper1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Inflammasome Versus the Reelin Brakepaper1
- The Microglial Thesis (Downloadable PDF)paper1
DLG4 (PSD-95) Reelin, synapse & ECM–PNN 25 docs
Matched on
DLG4 PSD-?95- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper7
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper7
- Cofilin Serine 3paper4
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper4
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper4
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper3
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- The Indifferent Neuronpaper3
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Astrocytespaper1
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper1
- Cofilin Serine 3 in Alzheimer's Diseasepaper1
- Cytoskeletal Collapse Nodenode1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper1
- Lithium in Alzheimer's Diseasepaper1
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper1
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper1
- Shatz & Brottpaper1
- Synaptic Pathologyconcept1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Load-Bearing Neuronpaper1
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper1
- The Synaptic Thesis (Downloadable PDF)paper1
TTR (transthyretin) Amyloid & Tau core 2 docs
Matched on
TTR transthyretinNRGN (neurogranin) Reelin, synapse & ECM–PNN 4 docs
Matched on
NRGN neurograninADAM10 Amyloid & Tau core 18 docs
Matched on
ADAM10- From Gut Ecology to the Failed Antidepressant Trialpaper10
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper9
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper4
- Fischer's Staged Deposit, 1907–1912paper3
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper3
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper2
- Endolysosomal Dysfunctionconcept2
- Epigenetic Repressionconcept2
- Selective Tau Disruptionconcept2
- Tau Scaffolding Interactionsconcept2
- The Genes That Protect — Phenocopy the Fortunatepaper2
- The Losing Axonpaper2
- Vesicular Traffickingconcept2
- Phase IIIpaper1
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper1
- The Biomarker Cascade (PhD Thesis)paper1
- The Narrow Gate Every Mitochondrial Protein Must Passpaper1
- TOMM40 Import Gateconcept1
SARM1 Bioenergetic / mito / NAD 8 docs
Matched on
SARM1- The Genetic Architecture of Neurodegeneration (PhD)paper16
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper14
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper7
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper6
- Mapping the Vascular onto the Genetic Dimension (PhD)paper2
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper2
- PARP Inhibitors and the Locus Coeruleuspaper2
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
GRIN2B Reelin, synapse & ECM–PNN 19 docs
Matched on
GRIN2B GluN2B NR2B- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper9
- The Indifferent Neuronpaper6
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper4
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper4
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper3
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper3
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper3
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper3
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Lithium in Alzheimer's Diseasepaper2
- The Genes That Protect — Phenocopy the Fortunatepaper2
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper1
- Can a Drug Copy the Luckiest Mutation?paper1
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper1
- From Gut Ecology to the Failed Antidepressant Trialpaper1
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper1
- Synaptic Plasticityconcept1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper1
NTRK1 (TrkA) Trophic / exercise / resilience 10 docs
Matched on
NTRK1 TrkA- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper35
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper4
- The Pedunculopontine Nucleus in Alzheimer's Diseasepaper3
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper1
- The Indifferent Neuronpaper1
- The Lipid That Kills Neurons and Spares Tumourspaper1
ULK1 Autophagy / lysosome / clearance 14 docs
Matched on
ULK1- Restoring Autophagy in Neurodegenerationpaper8
- Autophagic Flux in Alzheimer's Diseasepaper7
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper5
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper5
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper4
- Autophagy as the Driver of System-Wide Agingpaper3
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper3
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper3
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper2
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper2
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper2
- The Immunometabolic Nexus of Neurodegenerationpaper2
- Can Vaccines Protect Against Dementia?paper1
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper1
ACHE Neuromodulator / circadian / kynurenine 17 docs
Matched on
ACHE acetylcholinesterase AChE- The Pedunculopontine Nucleus in Alzheimer's Diseasepaper8
- Non-enzymatic AChE signalingconcept6
- Neurodegeneration as aberrant developmentconcept4
- Peptide Neurotherapeuticsconcept4
- Region-selective neuronal vulnerabilityconcept4
- T14 feedforward toxicity cascadeconcept4
- T14 Toxin Antagonismconcept4
- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper3
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- Choline, Phosphatidylcholine and APOE4 in Alzheimer's Diseasepaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Gravity-dependent brain perfusionconcept1
- Head-down time hypothesisconcept1
- PARP Inhibitors and the Locus Coeruleuspaper1
- Sleep posture and brain maintenanceconcept1
- Vascular-mechanical etiologyconcept1
MAPT Amyloid & Tau core 13 docs
Matched on
MAPT- The Genetic Architecture of Neurodegeneration (PhD)paper18
- Different Tau Strains Cause Different Diseasespaper6
- Restoring Autophagy in Neurodegenerationpaper6
- Mapping the Vascular onto the Genetic Dimension (PhD)paper4
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper3
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper2
- Templated Tau Misfolding Across the Three Phasespaper2
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- Seth Margolis Revisitedpaper1
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper1
SV2A Reelin, synapse & ECM–PNN 10 docs
Matched on
SV2A- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper14
- Standard Diagnostic Biomarkers Explainedpaper14
- Collapse, Traced Cell Type by Cell Typepaper5
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper4
- Seth Margolis Revisitedpaper4
- The Load-Bearing Neuronpaper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Beth Stevens's Complement-Pruning Programpaper1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
TIMP3 Reelin, synapse & ECM–PNN 6 docs
Matched on
TIMP-?3- Phase IIIpaper24
- The Genetic Architecture of Neurodegeneration (PhD)paper13
- Mapping the Vascular onto the Genetic Dimension (PhD)paper7
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- The Locus Coeruleus as Phase Bridgepaper1
ATP synthase (ATP5x) Bioenergetic / mito / NAD 6 docs
Matched on
ATP5A1 ATP synthase OSCP ATP5POTMEM119 Microglia & innate immunity 27 docs
Matched on
TMEM119- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper7
- The Microglial Thesis (Downloadable PDF)paper7
- BCG Vaccination in Alzheimer's Diseasepaper3
- Down Syndrome as the Disease Run in Fast-Forwardpaper2
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper2
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper2
- The Genetic Architecture of Neurodegeneration (PhD)paper2
- The Microglion That Silences Tau's Phosphatasepaper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Alzheimer's Disease — A Process in Timepaper1
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- Depression as Reversible Collapsepaper1
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Homeostatic Microglial Collapseconcept1
- Iron Chelation and GPX4 Stabilizationpaper1
- Microglial Restraint as Resiliencepaper1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Vascular Phasing (PhD Thesis)paper1
ACAT1 Lipid, sterol & membrane 11 docs
Matched on
ACAT1- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper19
- Estela Area-Gómez's MAM Theorypaper10
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Cholesterol Homeostasisconcept2
- Cholesterol Transportconcept2
- ER Stressconcept2
- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper2
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper2
- Tau Pathologyconcept2
- Lipid Metabolismconcept1
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper1
VPS35 Autophagy / lysosome / clearance 10 docs
Matched on
VPS35- Scott Small's Retromer and Endosomal Theorypaper13
- The Genetic Architecture of Neurodegeneration (PhD)paper8
- Smallpaper7
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper5
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper5
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper3
- Endosomal Nexusnode1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Clearance Collapse — One Machinery, Three Failurespaper1
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper1
CDKN1A (p21) Epigenetic & senescence 14 docs
Matched on
CDKN1A p21- The Cell Biology of the Word 'Ageing'paper11
- Cellular Senescenceconcept7
- The Immunometabolic Nexus of Neurodegenerationpaper6
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper4
- Cofilin Serine 3paper3
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper3
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper2
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper2
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Autophagy as the Driver of System-Wide Agingpaper1
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper1
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper1
- The Load-Bearing Neuronpaper1
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper1
NAMPT Bioenergetic / mito / NAD 8 docs
Matched on
NAMPT- NAD⁺ Restoration and CD38 Inhibitionpaper16
- The Genetic Architecture of Neurodegeneration (PhD)paper8
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper6
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper6
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper3
- PARP Inhibitors and the Locus Coeruleuspaper3
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper1
OPTN Neurodegeneration overlap 11 docs
Matched on
OPTN optineurin- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper15
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper6
- Restoring Autophagy in Neurodegenerationpaper6
- The Genetic Architecture of Neurodegeneration (PhD)paper6
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper2
- The Clearance Collapse — One Machinery, Three Failurespaper2
- The Mitochondrion as Nexus (PhD Thesis)paper2
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper2
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
CHAT (ChAT) Neuromodulator / circadian / kynurenine 9 docs
Matched on
ChAT choline acetyltransferase- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper21
- The Pedunculopontine Nucleus in Alzheimer's Diseasepaper6
- Anatomy of a Neurodegenerative Conduit — The Vagal Interfacepaper5
- Collapse, Traced Cell Type by Cell Typepaper3
- Choline, Phosphatidylcholine and APOE4 in Alzheimer's Diseasepaper2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper1
- Microglial Restraint as Resiliencepaper1
- PARP Inhibitors and the Locus Coeruleuspaper1
MEF2C GWAS / LOAD risk 9 docs
Matched on
MEF2C- The Brakes on Microglial Activation in Alzheimer's Diseasepaper13
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper11
- The Genetic Architecture of Neurodegeneration (PhD)paper7
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper3
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper2
- The Immunometabolic Nexus of Neurodegenerationpaper2
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper1
- cGAS–STING in Alzheimer's Diseasepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
HTRA1 Vascular / BBB 1 doc
Matched on
HTRA1ATF4 Cell death & ER stress 11 docs
Matched on
ATF4- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper17
- The Genetic Architecture of Neurodegeneration (PhD)paper7
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper5
- PARP Inhibitors and the Locus Coeruleuspaper2
- Comparing Different Viral Triggerspaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper1
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper1
- The Vascular Phasing (PhD Thesis)paper1
GRIA1 (GluA1) Reelin, synapse & ECM–PNN 17 docs
Matched on
GRIA1 GluA1 GluR1- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper6
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper4
- The Load-Bearing Neuronpaper4
- Cofilin Serine 3 in Alzheimer's Diseasepaper3
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper3
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper3
- Astrocytespaper2
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper2
- Cofilin Serine 3paper2
- Endosomal Traffickingconcept2
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper1
- LRP1 and the Templated Spread of Misfolded Proteinpaper1
- Scott Small's Retromer and Endosomal Theorypaper1
- Synaptic Pathologyconcept1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
NCAN (neurocan) Reelin, synapse & ECM–PNN 20 docs
Matched on
NCAN neurocan- The Perineuronal Matrix and Cortical Layer Twopaper13
- Phase IIIpaper3
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper2
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Fischer's Matrixpaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Norepinephrine as a Two-Armed Pincer on Taupaper1
- Perineuronal Netsconcept1
- The Enzyme That Cuts the Protective Latticepaper1
- The Load-Bearing Neuronpaper1
- The Matrix as the Seventh Axis of Collapsepaper1
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper1
- The Phase II → III Transitionpaper1
- The Proteolytic Degradation of the Perineuronal Net and the Loss of PV Interneuronspaper1
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper1
NOTCH3 Vascular / BBB 1 doc
Matched on
NOTCH3ROCK2 Reelin, synapse & ECM–PNN 12 docs
Matched on
ROCK2- Seth Margolis Revisitedpaper7
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper6
- Cofilin Serine 3paper5
- Smallpaper4
- The Load-Bearing Neuronpaper4
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper3
- Scott Small's Retromer and Endosomal Theorypaper3
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper2
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper1
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper1
- Structural Instructions at the Synapse Are Terminated by Destruction, Not Dephosphorylationpaper1
TBK1 Microglia & innate immunity 9 docs
Matched on
TBK1- Restoring Autophagy in Neurodegenerationpaper13
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper7
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper5
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper4
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper2
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper2
- cGAS–STING in Alzheimer's Diseasepaper1
- Convergent Autophagic Collapsepaper1
APPL1 Autophagy / lysosome / clearance 8 docs
Matched on
APPL1- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper13
- Scott Small's Retromer and Endosomal Theorypaper7
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper5
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper5
- Fischer's Staged Deposit, 1907–1912paper3
- Autophagic Flux in Alzheimer's Diseasepaper2
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper1
- Khachaturianpaper1
CX3CL1 (fractalkine) Microglia & innate immunity 15 docs
Matched on
CX3CL1 fractalkine- The Brakes on Microglial Activation in Alzheimer's Diseasepaper7
- The Losing Axonpaper6
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper5
- The Locus Coeruleus as Phase Bridgepaper5
- The Microglion That Silences Tau's Phosphatasepaper4
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- BCG Vaccination in Alzheimer's Diseasepaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Microglial Restraint as Resiliencepaper1
- Templated Tau Misfolding Across the Three Phasespaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
- The Microglial Thesis (Downloadable PDF)paper1
SDC (syndecan) Reelin, synapse & ECM–PNN 6 docs
Matched on
SDC1 SDC2 SDC3 SDC4 syndecan- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper12
- The Enzyme That Cuts the Protective Latticepaper9
- One Sugar Lattice, Three Jobspaper8
- Norepinephrine as a Two-Armed Pincer on Taupaper5
- The Inflammasome Versus the Reelin Brakepaper2
- Todd Golde's Amyloid Cascade, Read for What It Addspaper1
TYROBP GWAS / LOAD risk 16 docs
Matched on
TYROBP DAP12- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper7
- The Microglial Thesis (Downloadable PDF)paper7
- The Genetic Architecture of Neurodegeneration (PhD)paper6
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper4
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Metabolic-Homeostatic Axisnode1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- Oskar Fischer's Eight Stages of Plaque Formationpaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The Plaque Was Staged Before It Was Countedpaper1
HDAC2 Epigenetic & senescence 3 docs
Matched on
HDAC2SNAP25 Reelin, synapse & ECM–PNN 6 docs
Matched on
SNAP-?25VCAN (versican) Reelin, synapse & ECM–PNN 24 docs
Matched on
VCAN versican- Phase IIIpaper3
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper3
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper3
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper2
- Perineuronal Netsconcept2
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper2
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper2
- cognitive resilienceconcept1
- Collapse, Traced Cell Type by Cell Typepaper1
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Homeostatic Microglial Collapseconcept1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Norepinephrine as a Two-Armed Pincer on Taupaper1
- The Enzyme That Cuts the Protective Latticepaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Load-Bearing Neuronpaper1
- The Matrix as the Seventh Axis of Collapsepaper1
- The Perineuronal Matrix and Cortical Layer Twopaper1
- The Phase II → III Transitionpaper1
- The Plaque Was Staged Before It Was Countedpaper1
- The Proteolytic Degradation of the Perineuronal Net and the Loss of PV Interneuronspaper1
BACE2 Amyloid & Tau core 4 docs
Matched on
BACE2EIF2S1 (eIF2α) Cell death & ER stress 10 docs
Matched on
EIF2S1 eIF2- The Genetic Architecture of Neurodegeneration (PhD)paper9
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper7
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper6
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper3
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper3
- Comparing Different Viral Triggerspaper2
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper1
MFSD2A Vascular / BBB 6 docs
Matched on
MFSD2A- Mapping the Vascular onto the Genetic Dimension (PhD)paper17
- Choline, Phosphatidylcholine and APOE4 in Alzheimer's Diseasepaper8
- Vascular Pathology as a Substrate Across Phasespaper4
- The Vascular Phasing (PhD Thesis)paper3
- The Indifferent Neuronpaper2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
ABCA1 GWAS / LOAD risk 16 docs
Matched on
ABCA1- The Genetic Architecture of Neurodegeneration (PhD)paper5
- Cholesterol Homeostasisconcept4
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper4
- Estela Area-Gómez's MAM Theorypaper3
- Brain Lipid Homeostasis Restorationconcept2
- Dietary Fatty Acid APOE4 Rescueconcept2
- Lipid Metabolismconcept2
- Lipid Transportconcept2
- Membrane Biologyconcept2
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper2
- Autophagic Collapseconcept1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Rappoportpaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper1
- Zhen Huang's Competitive Synaptic Plasticity and the Amyloid-β Monomer Depletion Modelpaper1
SALL1 Microglia & innate immunity 23 docs
Matched on
SALL1- BCG Vaccination in Alzheimer's Diseasepaper5
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper3
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper2
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper2
- The Microglial Thesis (Downloadable PDF)paper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Alzheimer's Disease — A Process in Timepaper1
- Can Vaccines Protect Against Dementia?paper1
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Depression as Reversible Collapsepaper1
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Homeostatic Microglial Collapseconcept1
- Iron Chelation and GPX4 Stabilizationpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Vascular Phasing (PhD Thesis)paper1
SIRT3 Bioenergetic / mito / NAD 11 docs
Matched on
SIRT3- NAD⁺ Restoration and CD38 Inhibitionpaper8
- PARP Inhibitors and the Locus Coeruleuspaper8
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper5
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper3
- The Genes That Protect — Phenocopy the Fortunatepaper2
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper1
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The Clearance Collapse — One Machinery, Three Failurespaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
TRPML1 Autophagy / lysosome / clearance 16 docs
Matched on
TRPML1 MCOLN1- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper6
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper5
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper4
- Ralph Nixon's Inside-Out Thesispaper3
- Comparing Different Viral Triggerspaper2
- Khachaturianpaper2
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper2
- Restoring Autophagy in Neurodegenerationpaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Autophagic Fluxconcept1
- Lysosomal Dysfunctionconcept1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper1
KL (klotho) Trophic / exercise / resilience 9 docs
Matched on
klotho- The Genes That Protect — Phenocopy the Fortunatepaper17
- Atherosclerosis as AD driverconcept2
- Gravity-dependent brain vulnerabilityconcept2
- Head-down time and dementiaconcept2
- Immunosenescence as central aging mechanismconcept2
- Limbic brain as circavital clock locusconcept2
- Programmed aging clock model of ADconcept2
- Systemic circulating factors governing neurodegenerationconcept2
- Vascular-sleep interactionconcept2
MS4A GWAS / LOAD risk 9 docs
Matched on
MS4A4A MS4A6A MS4A- The Genetic Architecture of Neurodegeneration (PhD)paper15
- The Genes That Protect — Phenocopy the Fortunatepaper9
- Mapping the Vascular onto the Genetic Dimension (PhD)paper2
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- Microglial Restraint as Resiliencepaper1
- The Innate-Immune Sensor That Converts the Diseasepaper1
- The Microglial Thesis (Downloadable PDF)paper1
NLRP1 Microglia & innate immunity 3 docs
Matched on
NLRP1PICALM GWAS / LOAD risk 16 docs
Matched on
PICALM- The Genetic Architecture of Neurodegeneration (PhD)paper9
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper4
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper3
- Mapping the Vascular onto the Genetic Dimension (PhD)paper3
- Comparing Different Viral Triggerspaper2
- Autophagyconcept1
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper1
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper1
- Endosomal Traffickingconcept1
- Khachaturianpaper1
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper1
- Rappoportpaper1
- Scott Small's Retromer and Endosomal Theorypaper1
- Smallpaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper1
AGER (RAGE) Vascular / BBB 8 docs
Matched on
AGER RAGE- Mapping the Vascular onto the Genetic Dimension (PhD)paper17
- The Somatostatin Interneuron in Alzheimer's Diseasepaper4
- Vascular Pathology as a Substrate Across Phasespaper4
- The Vascular Phasing (PhD Thesis)paper2
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper1
- Depression as Reversible Collapsepaper1
- Down Syndrome as the Disease Run in Fast-Forwardpaper1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
ADAMTS5 Reelin, synapse & ECM–PNN 10 docs
Matched on
ADAMTS-?5- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper11
- Down Syndrome as the Disease Run in Fast-Forwardpaper5
- One Sensor, Two Collapses — Which Arm Matters More?paper4
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- Can a Drug Copy the Luckiest Mutation?paper2
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- The Inflammasome Versus the Reelin Brakepaper1
- The Phase II → III Transitionpaper1
SMPD1 (acid sphingomyelinase) Lipid, sterol & membrane 3 docs
Matched on
SMPD1 acid sphingomyelinase ASMaseSMPD3 Lipid, sterol & membrane 3 docs
Matched on
SMPD3 neutral sphingomyelinaseTLR4 Microglia & innate immunity 18 docs
Matched on
TLR4- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper4
- Can Vaccines Protect Against Dementia?paper3
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper3
- The Innate-Immune Sensor That Converts the Diseasepaper3
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper2
- Neurotropic Viral Invasion of the Central Nervous Systempaper2
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper2
- Depression as Reversible Collapsepaper1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- Neuroinflammationconcept1
- One Sensor, Two Collapses — Which Arm Matters More?paper1
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper1
- Phase IIpaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
- Vaccines That May Prevent Dementiapaper1
TPH2 Neuromodulator / circadian / kynurenine 5 docs
Matched on
TPH2- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper13
- From Gut Ecology to the Failed Antidepressant Trialpaper6
- Depression as Reversible Collapsepaper5
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper5
- The Genetic Architecture of Neurodegeneration (PhD)paper1
ACSL4 Oxidative stress & ferroptosis 8 docs
Matched on
ACSL4- Estela Area-Gómez's MAM Theorypaper9
- Phase IIpaper6
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper5
- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper3
- The Genetic Architecture of Neurodegeneration (PhD)paper2
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The Locus Coeruleus as Phase Bridgepaper1
- The Phase II → III Transitionpaper1
ARNTL (BMAL1) Neuromodulator / circadian / kynurenine 10 docs
Matched on
BMAL1 ARNTL- Beth Stevens's Complement-Pruning Programpaper11
- Antimicrobial hypothesis of amyloidconcept2
- BBB breakdown cascadeconcept2
- Circadian Immune Regulationconcept2
- Human-germ interaction modelconcept2
- Neuroimmune Surveillanceconcept2
- Neurovascular unit as disease originconcept2
- SORL1 Lysosomal Functionconcept2
- The Failing Clock That Stops Defending the Brainstempaper2
- Viral Pathogenesisconcept1
CD68 Microglia & innate immunity 14 docs
Matched on
CD68- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper6
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper4
- The Plaque Was Staged Before It Was Countedpaper4
- Oskar Fischer's Eight Stages of Plaque Formationpaper3
- Microglial Restraint as Resiliencepaper2
- Depression as Reversible Collapsepaper1
- Fischer's Eighth Stage as a Measurement of Rate Against Host Capacitypaper1
- Fischer's Sixth Stage and the Leptomeningeal Compartment It Never Enteredpaper1
- Fischer's Staged Deposit, 1907–1912paper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- Lithium in Alzheimer's Diseasepaper1
- Phase IIIpaper1
- Sleep as the Shared Off-Line State of Every Collapse Axispaper1
CYCS (cytochrome c) Bioenergetic / mito / NAD 10 docs
Matched on
CYCS cytochrome c(?! oxidase)- The Mitochondrion as Nexus (PhD Thesis)paper11
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper6
- Blocking the Aβ–ABAD Complex — A Pharmacologypaper4
- Autophagic Collapseconcept1
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper1
- Plaques Are Tombstones, Not Killerspaper1
- Ralph Nixon's Inside-Out Thesispaper1
- The Narrow Gate Every Mitochondrial Protein Must Passpaper1
- TOMM40 Import Gateconcept1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
SSH1 (slingshot-1) Reelin, synapse & ECM–PNN 3 docs
Matched on
SSH1 slingshot[- ]?1- The Load-Bearing Neuronpaper26
- Cofilin Serine 3paper1
- Shatz & Brottpaper1
ABCA7 GWAS / LOAD risk 8 docs
Matched on
ABCA7- The Genetic Architecture of Neurodegeneration (PhD)paper13
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper5
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper3
- Mapping the Vascular onto the Genetic Dimension (PhD)paper2
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper1
- Estela Area-Gómez's MAM Theorypaper1
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper1
- The Innate-Immune Sensor That Converts the Diseasepaper1
ABI3 GWAS / LOAD risk 15 docs
Matched on
ABI3- The Genetic Architecture of Neurodegeneration (PhD)paper8
- Todd Golde's Amyloid Cascade, Read for What It Addspaper3
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper2
- Microglial Restraint as Resiliencepaper2
- The Genes That Protect — Phenocopy the Fortunatepaper2
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Amyloid-β Restrains Microglia Twicepaper1
- Chronobiologic neuroprotection via melatoninconcept1
- Cognitive resilience as dynamic protective conceptconcept1
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Multifactorial prevention through modifiable risk factorsconcept1
- Population-specific AD genetic signaturesconcept1
- The Losing Axonpaper1
- The Microglial Thesis (Downloadable PDF)paper1
BCL2 (Bcl-2) Cell death & ER stress 12 docs
Matched on
BCL2 Bcl-?2- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper6
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper3
- Lithium in Alzheimer's Diseasepaper3
- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper3
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper2
- Comparing Different Viral Triggerspaper2
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper2
- Cellular Senescenceconcept1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- Plaques Are Tombstones, Not Killerspaper1
- Restoring Autophagy in Neurodegenerationpaper1
- The Cell Biology of the Word 'Ageing'paper1
CHI3L1 (YKL-40) Astrocyte & glial markers 6 docs
Matched on
CHI3L1 YKL-?40- The Biomarker Cascade (PhD Thesis)paper20
- The Vascular Phasing (PhD Thesis)paper2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper1
- Phase IIpaper1
- Standard Diagnostic Biomarkers Explainedpaper1
DYRK1A Amyloid & Tau core 2 docs
Matched on
DYRK1AKCNC (Kv3) Neuromodulator / circadian / kynurenine 6 docs
Matched on
Kv3 KCNC1 KCNC3- The Genetic Architecture of Neurodegeneration (PhD)paper10
- Phase IIIpaper5
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper5
- The Somatostatin Interneuron in Alzheimer's Diseasepaper3
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper2
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
MAPK1/3 (ERK1/2) Kinase & growth-factor signalling 13 docs
Matched on
MAPK[13] ERK1/2 ERK- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper4
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper3
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper3
- The Indifferent Neuronpaper3
- Depression as Reversible Collapsepaper2
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper2
- From Gut Ecology to the Failed Antidepressant Trialpaper2
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper2
- BDNF and the Trophic Failure of the Synapse in Alzheimer's Diseasepaper1
- Can a Drug Copy the Luckiest Mutation?paper1
- Gouraspaper1
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
SLC2A1 (GLUT1) Vascular / BBB 5 docs
Matched on
GLUT1 SLC2A1- Mapping the Vascular onto the Genetic Dimension (PhD)paper15
- Vascular Pathology as a Substrate Across Phasespaper6
- The Vascular Phasing (PhD Thesis)paper3
- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
VDAC1 Bioenergetic / mito / NAD 6 docs
Matched on
VDAC1 VDAC- LL-37, CLIC1 and Microglial Lysosomal Failurepaper11
- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper7
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper3
- cGAS–STING in Alzheimer's Diseasepaper2
- The Mitochondrion as Nexus (PhD Thesis)paper2
- The Narrow Gate Every Mitochondrial Protein Must Passpaper1
ABCB1 (P-gp) Vascular / BBB 8 docs
Matched on
ABCB1 P-?glycoprotein- Mapping the Vascular onto the Genetic Dimension (PhD)paper8
- The Lipid That Kills Neurons and Spares Tumourspaper5
- PARP Inhibitors and the Locus Coeruleuspaper3
- Vascular Pathology as a Substrate Across Phasespaper3
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- The Vascular Phasing (PhD Thesis)paper2
- Restoring Autophagy in Neurodegenerationpaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
CHRNA7 Neuromodulator / circadian / kynurenine 9 docs
Matched on
CHRNA7 7 ?nAChR alpha-?7 nicotinic- Anatomy of a Neurodegenerative Conduit — The Vagal Interfacepaper17
- Denervation supersensitivityconcept1
- Moosmann & Sohrepaper1
- Neurodegeneration as aberrant developmentconcept1
- Non-enzymatic AChE signalingconcept1
- Peptide Neurotherapeuticsconcept1
- Region-selective neuronal vulnerabilityconcept1
- T14 feedforward toxicity cascadeconcept1
- T14 Toxin Antagonismconcept1
CLU GWAS / LOAD risk 12 docs
Matched on
clusterin CLU- The Genetic Architecture of Neurodegeneration (PhD)paper8
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper4
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- Mapping the Vascular onto the Genetic Dimension (PhD)paper2
- The Losing Axonpaper2
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper1
- Khachaturianpaper1
- Phase IIpaper1
- The Brain's Border Gatepaper1
- The Microglial Thesis (Downloadable PDF)paper1
- Todd Golde's Amyloid Cascade, Read for What It Addspaper1
EIF2AK3 (PERK) Cell death & ER stress 13 docs
Matched on
EIF2AK3 PERK- PERK DLX1 Tau Axisconcept4
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- Abeta aggregation as necessary initiating eventconcept2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- Genetic evidence as gold standard for causalityconcept2
- Long preclinical phase of AD pathologyconcept2
- Multifactorial modulation of disease trajectoryconcept2
- Todd Golde's Amyloid Cascade, Read for What It Addspaper2
- Translational Regulation in Tauopathyconcept2
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper1
FUS Neurodegeneration overlap 9 docs
Matched on
FUS- The Genetic Architecture of Neurodegeneration (PhD)paper10
- Restoring Autophagy in Neurodegenerationpaper5
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper2
- cGAS–STING in Alzheimer's Diseasepaper2
- Mapping the Vascular onto the Genetic Dimension (PhD)paper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper1
- Fischer's Sideliningpaper1
- Proving That Misfolded Proteins Spread Like Prionspaper1
IL18 Microglia & innate immunity 13 docs
Matched on
IL-?18- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper6
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper4
- The Inflammasome Versus the Reelin Brakepaper4
- NMDA Receptor Blockade, Perineuronal Net Dynamics and Cell Death Modalities in Alzheimer'spaper2
- Autophagy as the Driver of System-Wide Agingpaper1
- Can Vaccines Protect Against Dementia?paper1
- Depression as Reversible Collapsepaper1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- Tau Pathologyconcept1
- The Immunometabolic Nexus of Neurodegenerationpaper1
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
LAMP1 Autophagy / lysosome / clearance 10 docs
Matched on
LAMP-?1- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper7
- Fischer's Staged Deposit, 1907–1912paper4
- The Plaque Was Staged Before It Was Countedpaper4
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper3
- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper2
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper1
- Comparing Different Viral Triggerspaper1
- Oskar Fischer's Eight Stages of Plaque Formationpaper1
- Ralph Nixon's Inside-Out Thesispaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
SNAP29 Autophagy / lysosome / clearance 7 docs
Matched on
SNAP29- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper6
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper6
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper4
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper3
- Comparing Different Viral Triggerspaper2
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper2
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper2
GGA3 Autophagy / lysosome / clearance 3 docs
Matched on
GGA3NMNAT2 Bioenergetic / mito / NAD 6 docs
Matched on
NMNAT2- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper8
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper6
- The Genetic Architecture of Neurodegeneration (PhD)paper6
- Mapping the Vascular onto the Genetic Dimension (PhD)paper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
QPRT Neuromodulator / circadian / kynurenine 2 docs
Matched on
QPRTCASP3 Cell death & ER stress 15 docs
Matched on
CASP3 caspase-?3- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper7
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper2
- Seth Margolis Revisitedpaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Can a Drug Copy the Luckiest Mutation?paper1
- Environmental neurotoxicologyconcept1
- Gut-brain axis in ADconcept1
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper1
- Metabolic-neurodegenerative disease connectionconcept1
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper1
- Plaques Are Tombstones, Not Killerspaper1
- The Failing Clock That Stops Defending the Brainstempaper1
- The Lipid That Kills Neurons and Spares Tumourspaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- TXNIP as therapeutic targetconcept1
CDKN2A (p16) Epigenetic & senescence 3 docs
Matched on
CDKN2A p16INK4a p16IFNAR1/2 Down-syndrome chr21 4 docs
Matched on
IFNAR1 IFNAR2 IFNARATG5 Autophagy / lysosome / clearance 10 docs
Matched on
ATG5- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper8
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- Can Vaccines Protect Against Dementia?paper2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper2
- Astrocytespaper1
- Autophagic Flux in Alzheimer's Diseasepaper1
- Autophagy as the Driver of System-Wide Agingpaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
ATP13A2 (PARK9) Autophagy / lysosome / clearance 7 docs
Matched on
ATP13A2- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper7
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper6
- Restoring Autophagy in Neurodegenerationpaper4
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Comparing Different Viral Triggerspaper1
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper1
DNM1L Bioenergetic / mito / NAD 14 docs
Matched on
DRP1 DNM1L- The Indifferent Neuronpaper4
- The Mitochondrion as Nexus (PhD Thesis)paper4
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Anne Eckert's Neuroendocrine Theory and the Withdrawal of Protection in the Ageing Brainpaper1
- Autophagy as the Driver of System-Wide Agingpaper1
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper1
- Energy metabolism declineconcept1
- Epigenetic and genetic interplayconcept1
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper1
- Lifestyle and behavioral factorsconcept1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Multifactorial etiologyconcept1
IAPP Neurodegeneration overlap 5 docs
Matched on
IAPP amylinMBP (myelin basic protein) Myelin & axon inhibition 9 docs
Matched on
MBP myelin basic protein- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper7
- Astrocytespaper5
- The Genetic Architecture of Neurodegeneration (PhD)paper4
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- Lithium in Alzheimer's Diseasepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Templated Tau Misfolding Across the Three Phasespaper1
MTHFR Trophic / exercise / resilience 6 docs
Matched on
MTHFR- MTHFR as catalytic pre-existing factorconcept6
- Infectious-toxic-genetic synergyconcept4
- Personalized multifactorial etiologyconcept4
- Three-actor-group pathogenesisconcept4
- Mapping the Vascular onto the Genetic Dimension (PhD)paper3
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
OTX2 Reelin, synapse & ECM–PNN 8 docs
Matched on
OTX2- One Sugar Lattice, Three Jobspaper6
- The Perineuronal Matrix and Cortical Layer Twopaper4
- The Enzyme That Cuts the Protective Latticepaper3
- The Phase II → III Transitionpaper3
- Perineuronal Netsconcept2
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper2
- Matrix Sulfation Nodeconcept1
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper1
RAC1 Reelin, synapse & ECM–PNN 8 docs
Matched on
RAC1- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper12
- Cofilin Serine 3paper3
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper2
- Alzheimer's Disease as a Failure of Proteolytic Timing, Read Out at Cofilin Serine 3paper1
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper1
- Seth Margolis Revisitedpaper1
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper1
SYN1 (synapsin) Reelin, synapse & ECM–PNN 7 docs
Matched on
SYN1 synapsin- The Indifferent Neuronpaper12
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper5
- Collapse, Traced Cell Type by Cell Typepaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- LRP1 and the Templated Spread of Misfolded Proteinpaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
- α-Synuclein Templating and Synucleinopathy Propagationpaper1
CD36 Microglia & innate immunity 10 docs
Matched on
CD36- The Innate-Immune Sensor That Converts the Diseasepaper7
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper3
- The Drivers of Microglial Dysfunction in Alzheimer's Disease, Ranked by Causal Weightpaper3
- Amyloid-β Restrains Microglia Twicepaper2
- Astrocytespaper1
- One Sensor, Two Collapses — Which Arm Matters More?paper1
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper1
- Phase IIpaper1
- The Inflammasome Versus the Reelin Brakepaper1
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper1
CR1 GWAS / LOAD risk 10 docs
Matched on
CR1- The Genetic Architecture of Neurodegeneration (PhD)paper8
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper3
- Mapping the Vascular onto the Genetic Dimension (PhD)paper3
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Beth Stevens's Complement-Pruning Programpaper1
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
- The Microglial Thesis (Downloadable PDF)paper1
- Vaccines That May Prevent Dementiapaper1
- Zhen Huang's Competitive Synaptic Plasticity and the Amyloid-β Monomer Depletion Modelpaper1
NDST1 Reelin, synapse & ECM–PNN 10 docs
Matched on
NDST1- Can a Drug Copy the Luckiest Mutation?paper6
- The Load-Bearing Neuronpaper3
- Cofilin Serine 3 in Alzheimer's Diseasepaper2
- Cofilin Serine 3paper2
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper2
- One Sugar Lattice, Three Jobspaper2
- Cortical Immature Neurons of Layer IIpaper1
- Different Tau Strains Cause Different Diseasespaper1
- Tau Kindling in the Locus Coeruleuspaper1
- The Inflammasome Versus the Reelin Brakepaper1
TDO2 Neuromodulator / circadian / kynurenine 5 docs
Matched on
TDO2 TDOTH (tyrosine hydroxylase) Neuromodulator / circadian / kynurenine 9 docs
Matched on
tyrosine hydroxylase- The Ventral Tegmental Area in Alzheimer's Diseasepaper8
- The Timing of Locus Coeruleus Loss in Alzheimer's Diseasepaper4
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper3
- Collapse, Traced Cell Type by Cell Typepaper1
- Iron Chelation and GPX4 Stabilizationpaper1
- PARP Inhibitors and the Locus Coeruleuspaper1
- Templated Tau Misfolding Across the Three Phasespaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
- α-Synuclein Templating and Synucleinopathy Propagationpaper1
CD200 Microglia & innate immunity 5 docs
Matched on
CD200- The Brakes on Microglial Activation in Alzheimer's Diseasepaper12
- The Locus Coeruleus as Phase Bridgepaper5
- Alzheimer's Disease — A Process in Timepaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
CDK5 Amyloid & Tau core 11 docs
Matched on
CDK5- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper5
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper3
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper3
- Plaques Are Tombstones, Not Killerspaper2
- Can a Drug Copy the Luckiest Mutation?paper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Re-evaluating Höglinger's Complex I → Tau Programpaper1
- Tau Pathologyconcept1
- The Calcium Hypothesis and the Systems Failure Model of Alzheimer's Diseasepaper1
- The Locus Coeruleus and the Noradrenergic Prodrome of Alzheimer's Diseasepaper1
- The Microglion That Silences Tau's Phosphatasepaper1
HAPLN1 Reelin, synapse & ECM–PNN 10 docs
Matched on
HAPLN1- Phase IIIpaper5
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper3
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- Perineuronal Netsconcept2
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper2
- Can a Drug Copy the Luckiest Mutation?paper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The Raphe Nuclei in Alzheimer's Disease as a Subject in Their Own Rightpaper1
MMP3 Reelin, synapse & ECM–PNN 11 docs
Matched on
MMP-?3- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper6
- The Genetic Architecture of Neurodegeneration (PhD)paper3
- Down Syndrome as the Disease Run in Fast-Forwardpaper2
- Phase IIIpaper2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Cell Biology of the Word 'Ageing'paper1
- The Inflammasome Versus the Reelin Brakepaper1
- The Phase II → III Transitionpaper1
- The Vascular Phasing (PhD Thesis)paper1
RIPK1 Cell death & ER stress 5 docs
Matched on
RIPK1 RIP1 kinase- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper15
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper2
- A Cell-Type-Resolved Map of Death Modalities Across the Progression of Alzheimer'spaper1
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper1
- The Lipid That Kills Neurons and Spares Tumourspaper1
SYP (synaptophysin) Reelin, synapse & ECM–PNN 15 docs
Matched on
SYP synaptophysin- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper2
- Collapse, Traced Cell Type by Cell Typepaper2
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper2
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper2
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper2
- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper1
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper1
- Fischer's Staged Deposit, 1907–1912paper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Lithium in Alzheimer's Diseasepaper1
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper1
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper1
- Synaptic Pathologyconcept1
- Synaptic Plasticityconcept1
- The Microglion That Silences Tau's Phosphatasepaper1
IDE Amyloid & Tau core 8 docs
Matched on
IDE- IDE-insulin-Abeta competitionconcept5
- Lifestyle intervention for cognitive reversalconcept3
- Metabolic dysfunction as AD driverconcept3
- Network-based combination therapyconcept3
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper2
- LRP1 and the Templated Spread of Misfolded Proteinpaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
- α-Synuclein Templating and Synucleinopathy Propagationpaper1
IRF (3/7/8) Microglia & innate immunity 6 docs
Matched on
IRF3 IRF7 IRF8- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper12
- Amyloid-β Restrains Microglia Twicepaper3
- BCG Vaccination in Alzheimer's Diseasepaper1
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper1
- cGAS–STING in Alzheimer's Diseasepaper1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
P2RX7 Microglia & innate immunity 6 docs
Matched on
P2RX7 P2X7- The Inflammasome Versus the Reelin Brakepaper8
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper3
- The Innate-Immune Sensor That Converts the Diseasepaper3
- The Mitochondrion as Nexus (PhD Thesis)paper2
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper2
- cGAS–STING in Alzheimer's Diseasepaper1
PRKACA (PKA) Kinase & growth-factor signalling 14 docs
Matched on
PRKACA PKA- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Astrocytespaper2
- Calcium Homeostasisconcept2
- Lysosomal Acidificationconcept2
- Restoring Autophagy in Neurodegenerationpaper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper1
- Autophagic Flux in Alzheimer's Diseasepaper1
- Autophagy Failure Mechanisms in Neurodegeneration, and the Timeline of Plaque Formationpaper1
- Bioenergeticsconcept1
- Disciplinary Silos in Alzheimer's Disease Research, 1950–2020paper1
- Norepinephrine as a Two-Armed Pincer on Taupaper1
- The Cell Biology of the Word 'Ageing'paper1
- Three Subtractive Alzheimer's Trials That Engaged Their Target and Left Patients Worsepaper1
TMEM175 Autophagy / lysosome / clearance 6 docs
Matched on
TMEM175- LL-37, CLIC1 and Microglial Lysosomal Failurepaper5
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper5
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper4
- Comparing Different Viral Triggerspaper2
- Restoring Autophagy in Neurodegenerationpaper2
- The Genetic Architecture of Neurodegeneration (PhD)paper1
TOMM20 Bioenergetic / mito / NAD 8 docs
Matched on
TOM20 TOMM20- The Narrow Gate Every Mitochondrial Protein Must Passpaper8
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper2
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper2
- The Clearance Collapse — One Machinery, Three Failurespaper2
- The Mitochondrion as Nexus (PhD Thesis)paper2
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper1
- Alzheimer's Disease — A Process in Timepaper1
- TOMM40 Import Gateconcept1
ZBP1 Microglia & innate immunity 2 docs
Matched on
ZBP1AIF1 (Iba1) Microglia & innate immunity 9 docs
Matched on
AIF1 Iba-?1- Oskar Fischer's Eight Stages of Plaque Formationpaper5
- Fischer's Staged Deposit, 1907–1912paper3
- The Plaque Was Staged Before It Was Countedpaper3
- Autophagic Flux in Alzheimer's Diseasepaper2
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- Fischer's Eighth Stage as a Measurement of Rate Against Host Capacitypaper1
- Fischer's Sideliningpaper1
- Fischer's Sixth Stage and the Leptomeningeal Compartment It Never Enteredpaper1
- Microglial Restraint as Resiliencepaper1
ATG7 Autophagy / lysosome / clearance 10 docs
Matched on
ATG7- The Genetic Architecture of Neurodegeneration (PhD)paper5
- Autophagic Flux in Alzheimer's Diseasepaper2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper2
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper2
- Can Vaccines Protect Against Dementia?paper1
- Fischer's Staged Deposit, 1907–1912paper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
CTNNB1 (β-catenin) Kinase & growth-factor signalling 8 docs
Matched on
CTNNB1 catenin- Lithium in Alzheimer's Diseasepaper8
- Mapping the Vascular onto the Genetic Dimension (PhD)paper3
- Oligodendroglial Autophagy Failure and the Glial Network in Proteostatic Crisispaper2
- cGAS–STING in Alzheimer's Diseasepaper1
- Cofilin Serine 3paper1
- LRP1 and the Templated Spread of Misfolded Proteinpaper1
- Seth Margolis Revisitedpaper1
- Structural Instructions at the Synapse Are Terminated by Destruction, Not Dephosphorylationpaper1
GRIN2A Reelin, synapse & ECM–PNN 7 docs
Matched on
GRIN2A GluN2A NR2A- The Indifferent Neuronpaper9
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper3
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Synaptic Plasticityconcept1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper1
HS3ST2 Reelin, synapse & ECM–PNN 6 docs
Matched on
HS3ST2- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper7
- Can a Drug Copy the Luckiest Mutation?paper4
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper3
- Cortical Immature Neurons of Layer IIpaper2
- Different Tau Strains Cause Different Diseasespaper1
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper1
LIMK1 Reelin, synapse & ECM–PNN 7 docs
Matched on
LIMK1- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper5
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper3
- The Matrix as the Seventh Axis of Collapsepaper3
- Cytoskeletal Collapse Nodenode2
- The Load-Bearing Neuronpaper2
- The Synaptic Thesis (Downloadable PDF)paper2
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper1
NPY Neuromodulator / circadian / kynurenine 9 docs
Matched on
NPY neuropeptide Y- The Load-Bearing Neuronpaper9
- Cofilin Serine 3 in Alzheimer's Diseasepaper2
- Cofilin Serine 3paper1
- Matrix Sulfation Nodeconcept1
- Perineuronal Netsconcept1
- Reelin-ApoE receptor axis disruptionconcept1
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper1
- The Losing Axonpaper1
- The Somatostatin Interneuron in Alzheimer's Diseasepaper1
RORB Reelin, synapse & ECM–PNN 4 docs
Matched on
RORBTMEM106B Autophagy / lysosome / clearance 3 docs
Matched on
TMEM106BCOL4A1 Vascular / BBB 1 doc
Matched on
COL4A1CRP Microglia & innate immunity 8 docs
Matched on
CRP C-?reactive protein- Autophagic Flux in Alzheimer's Diseasepaper4
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper4
- Sleep as the Shared Off-Line State of Every Collapse Axispaper3
- Autophagy as the Driver of System-Wide Agingpaper2
- BCG Vaccination in Alzheimer's Diseasepaper1
- Depression as Reversible Collapsepaper1
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper1
- Restoring Autophagy in Neurodegenerationpaper1
MFN2 Bioenergetic / mito / NAD 8 docs
Matched on
MFN2- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper7
- The Genetic Architecture of Neurodegeneration (PhD)paper4
- Estela Area-Gómez's MAM Theorypaper1
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper1
- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
RTN4R (NgR) Myelin & axon inhibition 9 docs
Matched on
RTN4R NgR1? Nogo receptor- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper6
- The Pruning Receptor, the Licensing Architecture Above Cofilin, and One Shared Compartmentpaper3
- The Load-Bearing Neuronpaper2
- Cofilin Serine 3 in Alzheimer's Diseasepaper1
- Cofilin Serine 3paper1
- Endolysosomal Dysfunctionconcept1
- Microglial Immunometabolismconcept1
- Synaptic Competitionconcept1
- The Losing Axonpaper1
SLC18A2 (VMAT2) Neuromodulator / circadian / kynurenine 5 docs
Matched on
SLC18A2 VMAT2SLC1A2 (EAAT2/GLT-1) Astrocyte & glial markers 6 docs
Matched on
SLC1A2 EAAT2 GLT-?1- Collapse, Traced Cell Type by Cell Typepaper5
- The Cell Biology of the Word 'Ageing'paper5
- A Graded Synthesis of the Temporal, Cellular and Ecological Mechanisms of Alzheimer'spaper2
- Cellular Senescenceconcept2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper1
TXN Oxidative stress & ferroptosis 9 docs
Matched on
thioredoxin TXN- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper7
- The Bredesen ReCODE Protocol Evaluatedpaper2
- The Mitochondrion as Nexus (PhD Thesis)paper2
- From Synapse Loss to Neuronal Death in Alzheimer's Diseasepaper1
- Metabolic-neurodegenerative disease axisconcept1
- Oxidative stress and apoptosis pathwaysconcept1
- Pharmacological neuroprotectionconcept1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
- Type 2 diabetes as AD risk factorconcept1
CAT (catalase) Oxidative stress & ferroptosis 10 docs
Matched on
catalase- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper4
- Restoring Autophagy in Neurodegenerationpaper3
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper2
- Anne Eckert's Neuroendocrine Theory and the Withdrawal of Protection in the Ageing Brainpaper1
- Down Syndrome as the Disease Run in Fast-Forwardpaper1
- Environmental neurotoxicologyconcept1
- Gut-brain axis in ADconcept1
- Metabolic-neurodegenerative disease connectionconcept1
- The Mitochondrion as Nexus (PhD Thesis)paper1
- TXNIP as therapeutic targetconcept1
CLEC7A (dectin-1) Microglia & innate immunity 7 docs
Matched on
CLEC7A dectin-?1- Amyloid-β Restrains Microglia Twicepaper7
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper2
- The Losing Axonpaper2
- The Microglial Thesis (Downloadable PDF)paper2
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
DLX1 Reelin, synapse & ECM–PNN 7 docs
Matched on
DLX1- PERK DLX1 Tau Axisconcept4
- Abeta aggregation as necessary initiating eventconcept2
- Genetic evidence as gold standard for causalityconcept2
- Long preclinical phase of AD pathologyconcept2
- Multifactorial modulation of disease trajectoryconcept2
- Todd Golde's Amyloid Cascade, Read for What It Addspaper2
- Translational Regulation in Tauopathyconcept2
LPL Microglia & innate immunity 9 docs
Matched on
LPL- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper4
- The Microglial Thesis (Downloadable PDF)paper4
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper2
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Alzheimer's Disease — A Process in Timepaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Lithium in Alzheimer's Diseasepaper1
- Phase IIpaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
SLC40A1 (ferroportin) Oxidative stress & ferroptosis 5 docs
Matched on
SLC40A1 ferroportinAXL Microglia & innate immunity 5 docs
Matched on
AXLCAMK2A (CaMKII) Reelin, synapse & ECM–PNN 7 docs
Matched on
CAMK2A CaMKII- The Indifferent Neuronpaper4
- Cortical Immature Neurons of Layer IIpaper3
- The Microglion That Silences Tau's Phosphatasepaper3
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper1
- Margolispaper1
- The Innate-Immune Sensor That Converts the Diseasepaper1
EP300 (p300) Epigenetic & senescence 8 docs
Matched on
EP300 p300- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper4
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper3
- Autophagy as the Driver of System-Wide Agingpaper2
- How the Gut Nerve Reaches the Brainstempaper2
- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Genes That Protect — Phenocopy the Fortunatepaper1
HTR1A Neuromodulator / circadian / kynurenine 4 docs
Matched on
HTR1A 5-?HT1ALDLR Lipid, sterol & membrane 10 docs
Matched on
LDLR LDL receptor- LRP1 and the Templated Spread of Misfolded Proteinpaper6
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- Neurotropic Viral Invasion of the Central Nervous Systempaper1
- Reelin, N-Sulfated Heparan Sulfate and ApoER2paper1
- Restoring Autophagy in Neurodegenerationpaper1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper1
- α-Synuclein Templating and Synucleinopathy Propagationpaper1
PDGFRB Vascular / BBB 2 docs
Matched on
PDGFRB PDGFR-?βSLC17A8 (VGLUT3) Neuromodulator / circadian / kynurenine 2 docs
Matched on
SLC17A8 VGLUT3STIM1 Cell death & ER stress 4 docs
Matched on
STIM1TFAM Bioenergetic / mito / NAD 8 docs
Matched on
TFAM- The Genetic Architecture of Neurodegeneration (PhD)paper5
- cGAS–STING, DNA Surveillance and Synaptic Resilience in Alzheimer's Diseasepaper3
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper2
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper1
- cGAS–STING in Alzheimer's Diseasepaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
TP53 (p53) Epigenetic & senescence 9 docs
Matched on
TP53 p53- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper4
- The Cell Biology of the Word 'Ageing'paper3
- cGAS–STING in Alzheimer's Diseasepaper2
- Autophagy as the Driver of System-Wide Agingpaper1
- Cellular Senescenceconcept1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- PARP Inhibitors and the Locus Coeruleuspaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
TXNIP Microglia & innate immunity 9 docs
Matched on
TXNIP- TXNIP as therapeutic targetconcept3
- Metabolic-neurodegenerative disease axisconcept2
- Oxidative stress and apoptosis pathwaysconcept2
- Pharmacological neuroprotectionconcept2
- Type 2 diabetes as AD risk factorconcept2
- Environmental neurotoxicologyconcept1
- Gut-brain axis in ADconcept1
- Metabolic-neurodegenerative disease connectionconcept1
- The Mitochondrion as Nexus (PhD Thesis)paper1
VIP Neuromodulator / circadian / kynurenine 6 docs
Matched on
VIP vasoactive intestinal peptide- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper5
- The Somatostatin Interneuron in Alzheimer's Diseasepaper4
- Collapse, Traced Cell Type by Cell Typepaper2
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper2
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper1
- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper1
CCL2 (MCP-1) Microglia & innate immunity 8 docs
Matched on
CCL2 MCP-?1- The Vascular Phasing (PhD Thesis)paper3
- Vascular Pathology as a Substrate Across Phasespaper3
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper2
- The Losing Axonpaper2
- Cellular Senescenceconcept1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The Cell Biology of the Word 'Ageing'paper1
CDK3 Epigenetic & senescence 6 docs
Matched on
CDK3INPP5D GWAS / LOAD risk 5 docs
Matched on
INPP5D SHIP1MAVS Microglia & innate immunity 3 docs
OLIG2 Down-syndrome chr21 3 docs
Matched on
OLIG2PEMT Lipid, sterol & membrane 1 doc
Matched on
PEMTSNAP47 Autophagy / lysosome / clearance 4 docs
Matched on
SNAP47SPP1 Microglia & innate immunity 9 docs
Matched on
SPP1 osteopontin- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper3
- The Microglial Thesis (Downloadable PDF)paper3
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper2
- Amyloid-β Restrains Microglia Twicepaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
- The Losing Axonpaper1
BAX Cell death & ER stress 6 docs
Matched on
BAX- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper4
- Ceramide as a Structural and Signalling Node in Alzheimer's Diseasepaper3
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper3
- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper1
- cGAS–STING in Alzheimer's Diseasepaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
BNIP3L (NIX) Bioenergetic / mito / NAD 4 docs
Matched on
BNIP3L NIXDDIT3 (CHOP) Cell death & ER stress 6 docs
Matched on
DDIT3 CHOP- The Genetic Architecture of Neurodegeneration (PhD)paper7
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper2
- Autophagy as the Driver of System-Wide Agingpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The Lipid That Kills Neurons and Spares Tumourspaper1
- The Vascular Phasing (PhD Thesis)paper1
FOXC1 Vascular / BBB 1 doc
Matched on
FOXC1HCAR2 (GPR109A) Bioenergetic / mito / NAD 2 docs
Matched on
HCAR2 GPR109A HCA2HSPA1A (Hsp70) Cell death & ER stress 7 docs
Matched on
HSPA1A Hsp70- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper4
- Restoring Autophagy in Neurodegenerationpaper3
- The Narrow Gate Every Mitochondrial Protein Must Passpaper2
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper1
- Autophagy as the Driver of System-Wide Agingpaper1
- Iron Chelation and GPX4 Stabilizationpaper1
- Oxidative Stress and Autophagy Failure in Alzheimer's Diseasepaper1
MSR1 Microglia & innate immunity 9 docs
Matched on
MSR1- The Brakes on Microglial Activation in Alzheimer's Diseasepaper4
- The Immunometabolic Nexus of Neurodegenerationpaper2
- Brain Immune Interfaceconcept1
- Immune Checkpoint Therapyconcept1
- Immunometabolic Checkpointsconcept1
- Meningeal T Cell Regulationconcept1
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper1
- Neuroimmunologyconcept1
- Phagocytic Clearanceconcept1
NEK7 Microglia & innate immunity 6 docs
Matched on
NEK7- The Innate-Immune Sensor That Converts the Diseasepaper6
- The Inflammasome Versus the Reelin Brakepaper3
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
- One Sensor, Two Collapses — Which Arm Matters More?paper1
- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper1
- The NLRP Inflammasome and the Perineuronal Net in Alzheimer's Diseasepaper1
NMRK1 Bioenergetic / mito / NAD 6 docs
Matched on
NMRK1 NRK1- The Genetic Architecture of Neurodegeneration (PhD)paper4
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper3
- NAD⁺ Restoration and CD38 Inhibitionpaper2
- PARP Inhibitors and the Locus Coeruleuspaper2
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
PLG (plasminogen) Vascular / BBB 5 docs
Matched on
PLG plasminogen- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper5
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper3
- Can a Drug Copy the Luckiest Mutation?paper2
- LRP1 and the Templated Spread of Misfolded Proteinpaper2
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper1
S100B Reelin, synapse & ECM–PNN 2 docs
Matched on
S100B S100βVAMP8 Autophagy / lysosome / clearance 7 docs
Matched on
VAMP8- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper6
- Gut Brain Axisconcept2
- Autophagyconcept1
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper1
- Microbial Pathogenesisconcept1
- Proteostasis Collapseconcept1
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper1
VMA21 Autophagy / lysosome / clearance 2 docs
CST7 (cystatin F) Microglia & innate immunity 9 docs
Matched on
CST7 cystatin F- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper2
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper2
- The Microglial Thesis (Downloadable PDF)paper2
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper1
- LL-37, Innate Immunity and Autophagic Collapse in Alzheimer's Diseasepaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
GAD1 (GAD67) Reelin, synapse & ECM–PNN 4 docs
Matched on
GAD1 GAD67GLP1R Neuromodulator / circadian / kynurenine 7 docs
Matched on
GLP-?1R GLP-?1 receptor- Depression as Reversible Collapsepaper5
- The Mitochondrion as Nexus (PhD Thesis)paper2
- Autophagic Flux in Alzheimer's Diseasepaper1
- Bioenergeticsconcept1
- Metabolic-Homeostatic Axisnode1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
HEXB Autophagy / lysosome / clearance 11 docs
Matched on
HEXB- The Brakes on Microglial Activation in Alzheimer's Diseasepaper2
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper1
- Alzheimer's Disease — A Process in Timepaper1
- BCG Vaccination in Alzheimer's Diseasepaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- Mitochondrial, Autophagy-Lysosomal and Metabolic Quality Control in Alzheimer's Diseasepaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- The Microglial Thesis (Downloadable PDF)paper1
- The Vascular Phasing (PhD Thesis)paper1
IL10 Microglia & innate immunity 9 docs
Matched on
IL-?10- The Brakes on Microglial Activation in Alzheimer's Diseasepaper4
- Can Vaccines Protect Against Dementia?paper1
- Carlo Abbate's Adult Neurogenesis Theory of Alzheimer's Disease, Critically Evaluatedpaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper1
- Restoring Autophagy in Neurodegenerationpaper1
- The Immunometabolic Nexus of Neurodegenerationpaper1
- Todd Golde's Amyloid Cascade, Read for What It Addspaper1
- Vaccines That May Prevent Dementiapaper1
LCMT1 Kinase & growth-factor signalling 3 docs
NLRP2 Microglia & innate immunity 2 docs
Matched on
NLRP2PPP1CA (PP1) Kinase & growth-factor signalling 11 docs
Matched on
PPP1CA PP1- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper2
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper1
- Comparing Different Viral Triggerspaper1
- Compensatory Architecture at the Alzheimer Synapse Is Turnover Rate, Not Reservepaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- HSV-1 Suppression of Neuronal Autophagy as a Viral Route into Alzheimer's Diseasepaper1
- Tau Kindling in the Locus Coeruleuspaper1
- The Bredesen Protocol Compared Against the Convergent Collapse Frameworkpaper1
- The Microglion That Silences Tau's Phosphatasepaper1
- The Morphological and Molecular Basis of Convergent Autophagic Collapsepaper1
PRKCA (PKC) Kinase & growth-factor signalling 8 docs
Matched on
PRKCA PKC- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper3
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Layer II Immature Neurons, Disease-Associated Microglia and the Reelin–Ephexin5 Axispaper2
- cGAS–STING in Alzheimer's Diseasepaper1
- Margolispaper1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- Seth Margolis Revisitedpaper1
- The Indifferent Neuronpaper1
PTGS2 (COX-2) Microglia & innate immunity 8 docs
Matched on
PTGS2 COX-?2- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper5
- Environmental toxicology of neurodegenerationconcept1
- Lithium in Alzheimer's Diseasepaper1
- Mercury as primary AD causeconcept1
- Metal-protein interaction in diseaseconcept1
- Neurotransmitter disruption cascadeconcept1
- Phase IIIpaper1
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper1
RAB7A Autophagy / lysosome / clearance 6 docs
Matched on
RAB7A Rab7- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper5
- Axonal Transportconcept2
- The Cholinergic Nucleus Basalis in Alzheimer's Diseasepaper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper1
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper1
SMAD3 Kinase & growth-factor signalling 7 docs
Matched on
SMAD3- The Genetic Architecture of Neurodegeneration (PhD)paper4
- The Microglion That Silences Tau's Phosphatasepaper3
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The Biomarker Cascade (PhD Thesis)paper1
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper1
- The Microglial Thesis (Downloadable PDF)paper1
TIMP1 Reelin, synapse & ECM–PNN 5 docs
Matched on
TIMP-?1VCP Neurodegeneration overlap 6 docs
Matched on
VCP- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper3
- Restoring Autophagy in Neurodegenerationpaper3
- The Narrow Gate Every Mitochondrial Protein Must Passpaper2
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper2
- Convergent Autophagic Collapsepaper1
- TOMM40 Import Gateconcept1
VDR Neuromodulator / circadian / kynurenine 4 docs
Matched on
VDR vitamin D receptorABCG2 (BCRP) Vascular / BBB 3 docs
Matched on
ABCG2 BCRPC5AR1 Microglia & innate immunity 6 docs
Matched on
C5aR C5AR1- The Inflammasome–Complement–TREM2 Nexus in Alzheimer's Diseasepaper6
- Age-related immune dysfunction enables neurotropic virusesconcept1
- Neuroinflammation as primary driver connecting all AD subsystemsconcept1
- Systems approach to interconnected AD pathological hallmarksconcept1
- The Brakes on Microglial Activation in Alzheimer's Diseasepaper1
- Viral infection triggers chronic brain inflammationconcept1
CD2AP GWAS / LOAD risk 6 docs
Matched on
CD2APDEGS1 Lipid, sterol & membrane 2 docs
Matched on
DEGS1FGA/FGB/FGG (fibrinogen) Vascular / BBB 5 docs
Matched on
FGA FGB FGG fibrinogenFOXP3 Microglia & innate immunity 2 docs
Matched on
FOXP3HAPLN4 (Bral2) Reelin, synapse & ECM–PNN 8 docs
Matched on
HAPLN4 Bral2- Perineuronal Netsconcept2
- Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer'spaper2
- The Genetic Architecture of Neurodegeneration (PhD)paper2
- Collapse, Traced Cell Type by Cell Typepaper1
- Forty-Hertz Sensory Entrainment as a Candidate Disease-Modifying Therapy in Alzheimer'spaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Phase IIIpaper1
- Templated Misfolding as the Fourth Substrate of the Homeostatic–Matrix–Synaptic Modelpaper1
HAS1/2/3 Reelin, synapse & ECM–PNN 5 docs
Matched on
HAS1 HAS2 HAS3 hyaluronan synthaseIGF1 Trophic / exercise / resilience 9 docs
Matched on
IGF-?1- Adult Hippocampal Neurogenesis and the Substrate of Cognitive Reservepaper3
- Aging-epigenetic-genetic interactionconcept1
- Anne Eckert's Neuroendocrine Theory and the Withdrawal of Protection in the Ageing Brainpaper1
- ATN biomarker classification systemconcept1
- Autophagy as the Driver of System-Wide Agingpaper1
- Can Vaccines Protect Against Dementia?paper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Integrated molecular-to-network perspectiveconcept1
- Multi-level heterogeneity of ADconcept1
ITGAX Microglia & innate immunity 8 docs
Matched on
ITGAX CD11c- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper2
- Aleksandra Deczkowska's DAM Program and the Matrix-Degrading Armpaper2
- The Microglial Thesis (Downloadable PDF)paper2
- Collapse, Traced Cell Type by Cell Typepaper1
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper1
- Phase IIpaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
SOAT1 Lipid, sterol & membrane 6 docs
Matched on
SOAT1- Estela Area-Gómez's MAM Theorypaper4
- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Mitochondria-Associated ER Membranes and Ceramide in Alzheimer's Diseasepaper2
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- The Mitochondria-Associated Membrane Hypothesis of Alzheimer's Disease, Evaluatedpaper1
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper1
TIMM23 Bioenergetic / mito / NAD 3 docs
Matched on
TIM23 TIMM23CD4 Microglia & innate immunity 3 docs
Matched on
CD4LEP (leptin) Neuromodulator / circadian / kynurenine 2 docs
Matched on
LEP leptinMRC1 (CD206) Microglia & innate immunity 7 docs
Matched on
MRC1 CD206- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper2
- The Immunometabolic Nexus of Neurodegenerationpaper2
- The Microglial Thesis (Downloadable PDF)paper2
- BCG Vaccination in Alzheimer's Diseasepaper1
- Beth Stevens's Complement-Pruning Programpaper1
- The Vascular Phasing (PhD Thesis)paper1
- Vascular Pathology as a Substrate Across Phasespaper1
NOS2 (iNOS) Microglia & innate immunity 5 docs
Matched on
NOS2 iNOSPDHA1 (PDH) Bioenergetic / mito / NAD 7 docs
Matched on
PDHA1 pyruvate dehydrogenase- Anne Eckert's Neuroendocrine Theory and the Withdrawal of Protection in the Ageing Brainpaper4
- Bioenergeticsconcept1
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper1
- CSF1R Inhibition Restores the Perineuronal Matrix and Destabilises the Rhythm It Supportspaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Metabolic-Homeostatic Axisnode1
- The Bredesen ReCODE Protocol Evaluatedpaper1
PPIF (cyclophilin D) Bioenergetic / mito / NAD 5 docs
Matched on
PPIF cyclophilin[- ]?D CypDRELCH Autophagy / lysosome / clearance 5 docs
Matched on
RELCH KIAA1468- The Indifferent Neuronpaper5
- Cholesterol Homeostasisconcept2
- AI Disease Model Discoveryconcept1
- Asymptomatic AD Phenotypingconcept1
- Membrane Lipid Dysregulationconcept1
SMAD7 Kinase & growth-factor signalling 6 docs
Matched on
SMAD7- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper2
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper2
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper2
- The Microglial Thesis (Downloadable PDF)paper2
- Michal Schwartz's Protective Autoimmunity as the Systemic Upstream of the Microglial Nichepaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
STAT (1/3/6) Microglia & innate immunity 6 docs
Matched on
STAT1 STAT3 STAT6- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper4
- The Losing Axonpaper2
- Can Vaccines Protect Against Dementia?paper1
- From Gut Ecology to the Failed Antidepressant Trialpaper1
- Lithium in Alzheimer's Diseasepaper1
- Tryptophan Allocation Across the Kynurenine, NAD⁺ and Serotonergic Branchespaper1
VPS26 Autophagy / lysosome / clearance 6 docs
Matched on
VPS26- Scott Small's Retromer and Endosomal Theorypaper5
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper1
- Smallpaper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Clearance Collapse — One Machinery, Three Failurespaper1
VPS4A Autophagy / lysosome / clearance 7 docs
Matched on
VPS4A- Cofilin Serine 3 and the Two Endosomal Programmes That Describe Its Removalpaper3
- The Clearance Collapse — One Machinery, Three Failurespaper2
- Fischer's Staged Deposit, 1907–1912paper1
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- Residence Time as the Common Variable in Endosomal Traffic, Amyloid and Proteolysispaper1
- The Mitochondrion as Nexus (PhD Thesis)paper1
ADAMTS1 Reelin, synapse & ECM–PNN 4 docs
Matched on
ADAMTS-?1CD22 Microglia & innate immunity 1 doc
Matched on
CD22DNM2 Autophagy / lysosome / clearance 8 docs
Matched on
DNM2- The Clearance Collapse — One Machinery, Three Failurespaper2
- Age-dependent feedback loops in neurodegenerationconcept1
- AI Neurotherapeutic Discoveryconcept1
- BIN1 Autophagic Regulationconcept1
- ESCRT III Membrane Scissionconcept1
- Onset vs Progressionconcept1
- Proteasome Tau Feedbackconcept1
- Quality Control Collapseconcept1
HTR2A Neuromodulator / circadian / kynurenine 4 docs
Matched on
HTR2A 5-?HT2AIL1B Microglia & innate immunity 5 docs
Matched on
IL-?1β IL-?1beta IL1B IL-?1bINSR Neuromodulator / circadian / kynurenine 7 docs
Matched on
INSR insulin receptor- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper2
- Restoring Autophagy in Neurodegenerationpaper2
- Carla Shatz's Synaptic Restraint System and the C4d–LilrB2 Resultpaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper1
MAP2 Reelin, synapse & ECM–PNN 6 docs
Matched on
MAP2- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper3
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper2
- Fischer's Staged Deposit, 1907–1912paper1
- Gunnar Gouras's Intraneuronal Amyloid and the Synaptic Endosome, Twenty-Eight Years Onpaper1
- Nine Accounts of the Failing Synapse, and the One Lesion They Describepaper1
- The Indifferent Neuronpaper1
NPC1 Autophagy / lysosome / clearance 3 docs
PPARGC1A Bioenergetic / mito / NAD 1 doc
Matched on
PPARGC1A PGC-?1α PGC-?1alpha PGC-?1aPQBP1 Epigenetic & senescence 3 docs
RNASEH2A/B/C Microglia & innate immunity 2 docs
Matched on
RNASEH2[ABC] RNase H2SIRT6 Bioenergetic / mito / NAD 6 docs
Matched on
SIRT6- The Genes That Protect — Phenocopy the Fortunatepaper3
- Epigenetic Erosion as the Reversible Information Layer of Alzheimer's Diseasepaper2
- Bess Frost's Chromatin Programme, the Elements It Releases, and the Restraint on cGASpaper1
- cGAS–STING in Alzheimer's Diseasepaper1
- NAD⁺ Restoration and CD38 Inhibitionpaper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
SLC7A11 (xCT) Oxidative stress & ferroptosis 5 docs
Matched on
SLC7A11 xCTSOD2 Oxidative stress & ferroptosis 4 docs
Matched on
SOD2ALOX15 Oxidative stress & ferroptosis 5 docs
Matched on
ALOX15 15-LOXASAH1 (acid ceramidase) Lipid, sterol & membrane 1 doc
Matched on
ASAH1 acid ceramidaseCD74 Microglia & innate immunity 3 docs
Matched on
CD74Often named withMIF
HAMP (hepcidin) Oxidative stress & ferroptosis 1 doc
Matched on
HAMP hepcidinHMOX1 Oxidative stress & ferroptosis 3 docs
Matched on
HMOX1 HO-1 heme oxygenaseMAPK8 (JNK) Kinase & growth-factor signalling 5 docs
Matched on
MAPK8 JNK- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper3
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- BDNF and the Trophic Failure of the Synapse in Alzheimer's Diseasepaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- The Somatostatin Interneuron in Alzheimer's Diseasepaper1
MLKL Cell death & ER stress 2 docs
OPA1 Bioenergetic / mito / NAD 4 docs
Matched on
OPA1PLD3 GWAS / LOAD risk 4 docs
SATB1 Epigenetic & senescence 3 docs
SLC7A5 (LAT1) Vascular / BBB 4 docs
Matched on
SLC7A5 LAT1SMAD2 Kinase & growth-factor signalling 6 docs
Matched on
SMAD2- The Brakes on Microglial Activation in Alzheimer's Diseasepaper2
- The Homeostatic–Matrix–Synaptic (HMS) Collapse Modelpaper2
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Containment, Not Clearance, as the Variable That Changes First in the Ageing Brainpaper1
- The Microglial Thesis (Downloadable PDF)paper1
- The Microglion That Silences Tau's Phosphatasepaper1
TET1/2/3 Epigenetic & senescence 2 docs
Matched on
TET1 TET2 TET3TFE3 Autophagy / lysosome / clearance 5 docs
Matched on
TFE3- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper3
- The Genetic Architecture of Neurodegeneration (PhD)paper2
- A Funnel Model from Upstream Etiologies to PANTHOS in Alzheimer's Diseasepaper1
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
TLR2 Microglia & innate immunity 5 docs
Matched on
TLR2VEGF Trophic / exercise / resilience 6 docs
Matched on
VEGF- Glymphatic Clearance Failure in Alzheimer's Disease and the Noradrenergic Switchpaper2
- Telling Different Dementias Apartpaper2
- Biomarkers of Vascular Dementia and Their Overlap with Alzheimer's Diseasepaper1
- Cellular Senescenceconcept1
- Margolispaper1
- The Sulfated Matrix That Gates Astrocytic Cholesterol Delivery to the Synapsepaper1
ACSL1 Lipid, sterol & membrane 5 docs
Matched on
ACSL1- Choline, Phosphatidylcholine and APOE4 in Alzheimer's Diseasepaper2
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper2
- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- Collapse, Traced Cell Type by Cell Typepaper1
- The Microglial Thesis (Downloadable PDF)paper1
ADAMTS2 Reelin, synapse & ECM–PNN 6 docs
Matched on
ADAMTS-?2AIM2 Microglia & innate immunity 4 docs
Matched on
AIM2CD163 Microglia & innate immunity 7 docs
Matched on
CD163- A Unified Synthesis of Microglial Contributions to Alzheimer's Diseasepaper1
- BCG Vaccination in Alzheimer's Diseasepaper1
- Beth Stevens's Complement-Pruning Programpaper1
- Pathogen Reactivation Across the Three Temporal Phases of Alzheimer's Diseasepaper1
- The Microglial Thesis (Downloadable PDF)paper1
- The Vascular Phasing (PhD Thesis)paper1
- Vascular Pathology as a Substrate Across Phasespaper1
CD28 Microglia & innate immunity 1 doc
Matched on
CD28CD47 Microglia & innate immunity 2 docs
Matched on
CD47CHL1 Reelin, synapse & ECM–PNN 5 docs
Matched on
CHL1- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper2
- Scott Small's Retromer and Endosomal Theorypaper2
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper1
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper1
- Smallpaper1
DBH Neuromodulator / circadian / kynurenine 3 docs
Matched on
DBH dopamine β-hydroxylaseFANCC Epigenetic & senescence 2 docs
Matched on
FANCCFLVCR2 Vascular / BBB 1 doc
Matched on
FLVCR2HEXIM1 Epigenetic & senescence 7 docs
Matched on
HEXIM1- Entropy as organizing principleconcept1
- Evolutionary mismatch hypothesisconcept1
- Microglial Protein Biomarkersconcept1
- Modifiability of AD riskconcept1
- Mosaic model of aging brainconcept1
- SorLA Lipid ER Regulationconcept1
- Transcriptional Pause Releaseconcept1
HSF1 Cell death & ER stress 2 docs
Matched on
HSF1ICAM1 Vascular / BBB 4 docs
Matched on
ICAM-?1IDO2 Neuromodulator / circadian / kynurenine 4 docs
Matched on
IDO2LAMP2 Autophagy / lysosome / clearance 6 docs
Matched on
LAMP-?2- Load, Capacity and the Boundary of Convergent Clearance Failure in Neurodegenerationpaper2
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- Oxidative Stress and Autophagy Failure in Alzheimer's Diseasepaper1
- Restoring Autophagy in Neurodegenerationpaper1
- The Bredesen ReCODE Protocol Evaluatedpaper1
- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper1
LILRB5 GWAS / LOAD risk 2 docs
Matched on
LILRB5NGFR (p75NTR) Trophic / exercise / resilience 4 docs
Matched on
NGFR p75-?NTR p75 neurotrophin receptorNQO2 Oxidative stress & ferroptosis 3 docs
Matched on
NQO2NRG1 (neuregulin-1) Reelin, synapse & ECM–PNN 5 docs
Matched on
NRG1 neuregulin-?1- The Genetic Architecture of Neurodegeneration (PhD)paper3
- Christopher Ramsden's ApoE-Peroxidation and ApoER2 Theory, Revisitedpaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- Lipid Peroxidation and ApoER2–Dab1 Disruption in Sporadic Alzheimer's Diseasepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
OGDH (KGDH) Bioenergetic / mito / NAD 2 docs
Matched on
OGDH KGDH ketoglutarate dehydrogenaseRIPK3 Cell death & ER stress 2 docs
ROCK1 Reelin, synapse & ECM–PNN 5 docs
Matched on
ROCK1SIRPA Microglia & innate immunity 2 docs
Matched on
SIRPA SIRPSIRT7 Bioenergetic / mito / NAD 4 docs
Matched on
SIRT7TFRC Oxidative stress & ferroptosis 4 docs
Matched on
TFRC transferrin receptorTSPO Microglia & innate immunity 5 docs
Matched on
TSPO translocator protein- Anne Eckert's Neuroendocrine Theory and the Withdrawal of Protection in the Ageing Brainpaper3
- Autophagic Flux in Alzheimer's Diseasepaper1
- Depression as Reversible Collapsepaper1
- Existing and Candidate Interventions Mapped onto the Convergent Collapse Frameworkpaper1
- LL-37, CLIC1 and Microglial Lysosomal Failurepaper1
VPS29 Autophagy / lysosome / clearance 4 docs
Matched on
VPS29VPS41 Autophagy / lysosome / clearance 2 docs
ACOX1 Lipid, sterol & membrane 3 docs
ADRB (β-AR) Neuromodulator / circadian / kynurenine 1 doc
Matched on
ADRB1 ADRB2 β[12]?-AR β-adrenergicAOAH Microglia & innate immunity 6 docs
Matched on
AOAHAPAF1 Cell death & ER stress 6 docs
Matched on
APAF1 Apaf-?1- Blocking the Aβ–ABAD Complex — A Pharmacologypaper1
- Cell Death Modalities in Alzheimer's Disease and Their Convergence at the Perineuronal Netpaper1
- Environmental neurotoxicologyconcept1
- Gut-brain axis in ADconcept1
- Metabolic-neurodegenerative disease connectionconcept1
- TXNIP as therapeutic targetconcept1
ATP2A2 (SERCA2) Cell death & ER stress 3 docs
Matched on
ATP2A2 SERCA- Khachaturianpaper4
- Calcium Homeostasisconcept1
- The Mitochondrion as Nexus (PhD Thesis)paper1
CANX (calnexin) Cell death & ER stress 4 docs
Matched on
CANX calnexin- Where Autophagic Failure Causes Neurodegeneration, and Where It Is a Consequencepaper3
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper1
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper1
- Scott Small's Retromer and Endosomal Theorypaper1
CD14 Microglia & innate immunity 4 docs
CHST3 Reelin, synapse & ECM–PNN 3 docs
Matched on
CHST3EPHA1 GWAS / LOAD risk 3 docs
FASN Lipid, sterol & membrane 3 docs
Matched on
FASN fatty acid synthaseGAP43 Reelin, synapse & ECM–PNN 2 docs
Matched on
GAP-?43GRAMD1B (Aster-B) Lipid, sterol & membrane 2 docs
Matched on
GRAMD1B Aster-?BH2AX Epigenetic & senescence 3 docs
Matched on
H2AXHDAC6 Epigenetic & senescence 3 docs
Matched on
HDAC6HMGB1 Microglia & innate immunity 5 docs
Matched on
HMGB1LPCAT3 Lipid, sterol & membrane 3 docs
Matched on
LPCAT3MCU Bioenergetic / mito / NAD 3 docs
Matched on
MCU mitochondrial calcium uniporterMFN1 Bioenergetic / mito / NAD 4 docs
Matched on
MFN1 mitofusin-?1NOS3 (eNOS) Vascular / BBB 1 doc
Matched on
NOS3 eNOSPLEKHM1 Autophagy / lysosome / clearance 3 docs
Matched on
PLEKHM1PLP1 Myelin & axon inhibition 3 docs
PPP5C (PP5) Kinase & growth-factor signalling 5 docs
Matched on
PPP5C PP5- Amyloid-β, the Oxidative Burst and Three Routes to a Disabled Phosphatasepaper2
- Asparaginyl Endopeptidase in the Locus Coeruleuspaper1
- Four Ways to Switch Off Protein Phosphatase 2A in the Cortical Neuronpaper1
- Tau Kindling in the Locus Coeruleuspaper1
- The Microglion That Silences Tau's Phosphatasepaper1
RAB11A Autophagy / lysosome / clearance 4 docs
Matched on
RAB11A Rab11- Ralph Nixon's Endosomal–Autophagic–Lysosomal Framework of Alzheimer's Disease, Gradedpaper2
- The Indifferent Neuronpaper2
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper1
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper1
SLC5A7 (CHT1) Neuromodulator / circadian / kynurenine 1 doc
Matched on
SLC5A7 CHT1STX17 (syntaxin-17) Autophagy / lysosome / clearance 3 docs
Matched on
STX17 syntaxin-?17TGFB1 Kinase & growth-factor signalling 6 docs
Matched on
TGFB1 TGF-?β1 TGF-?beta1- Alzheimer's Disease — A Process in Timepaper1
- Lysosomal Membrane Damage as the Upstream Determinant of Microglial Statepaper1
- Mapping the Vascular onto the Genetic Dimension (PhD)paper1
- The 50-Year Front — The Temporal Architecture of Alzheimer'spaper1
- The Biomarker Cascade (PhD Thesis)paper1
- The Genetic Architecture of Neurodegeneration (PhD)paper1
VAPB Neurodegeneration overlap 2 docs
Matched on
VAPBAANAT Neuromodulator / circadian / kynurenine 3 docs
Matched on
AANATADAR Microglia & innate immunity 2 docs
Matched on
ADAR1?ALOX5 Oxidative stress & ferroptosis 4 docs
Matched on
ALOX5 5-?LOXAPLP2 Amyloid & Tau core 2 docs
Matched on
APLP2CHST11 Reelin, synapse & ECM–PNN 3 docs
Matched on
CHST11CRH Neuromodulator / circadian / kynurenine 2 docs
Matched on
CRH corticotropin[- ]releasing hormoneDGAT2 Lipid, sterol & membrane 4 docs
Matched on
DGAT2EGFR Kinase & growth-factor signalling 3 docs
Matched on
EGFREPG5 Autophagy / lysosome / clearance 2 docs
GAD2 (GAD65) Reelin, synapse & ECM–PNN 2 docs
Matched on
GAD2 GAD65GAS6 Microglia & innate immunity 3 docs
GCLC Oxidative stress & ferroptosis 3 docs
Matched on
GCLCGPHN (gephyrin) Reelin, synapse & ECM–PNN 2 docs
Matched on
GPHN gephyrinHSP90AA1 (Hsp90) Cell death & ER stress 3 docs
Matched on
HSP90AA1 Hsp90ITM2B (BRI2) Amyloid & Tau core 2 docs
Matched on
ITM2B BRI2ITPR1 (IP3R) Cell death & ER stress 2 docs
Matched on
ITPR1 IP3 ?receptor IP3RJAK1 Microglia & innate immunity 4 docs
Matched on
JAK1JAK2 Microglia & innate immunity 1 doc
Matched on
JAK2KEAP1 Oxidative stress & ferroptosis 2 docs
Matched on
KEAP1LMNB1 Epigenetic & senescence 4 docs
Matched on
LMNB1 lamin B1MOG Myelin & axon inhibition 2 docs
Matched on
MOG myelin oligodendrocyte glycoproteinMRE11 Epigenetic & senescence 2 docs
Matched on
MRE11NMRK2 Bioenergetic / mito / NAD 4 docs
Matched on
NMRK2 NRK2NPTX2 Reelin, synapse & ECM–PNN 3 docs
Matched on
NPTX2 NarpPARL Bioenergetic / mito / NAD 3 docs
POLG Bioenergetic / mito / NAD 2 docs
Matched on
POLGSMCR8 Autophagy / lysosome / clearance 3 docs
Matched on
SMCR8SYNJ1 Down-syndrome chr21 1 doc
Matched on
SYNJ1WDR91 Autophagy / lysosome / clearance 2 docs
APBB1 Amyloid & Tau core 1 doc
APLP1 Amyloid & Tau core 2 docs
APOC1 GWAS / LOAD risk 2 docs
Matched on
APOC1AVP (vasopressin) Neuromodulator / circadian / kynurenine 2 docs
Matched on
AVP vasopressinCASP8 Cell death & ER stress 2 docs
Matched on
CASP8 caspase-?8CCR5 Microglia & innate immunity 2 docs
Matched on
CCR5CSNK1D (CK1δ) Kinase & growth-factor signalling 2 docs
Matched on
CSNK1D CK1 casein kinase 1ERBB4 Reelin, synapse & ECM–PNN 2 docs
Matched on
ERBB4EXT1 Reelin, synapse & ECM–PNN 3 docs
Matched on
EXT1FKBP5 Neuromodulator / circadian / kynurenine 2 docs
Matched on
FKBP5GPX1 Oxidative stress & ferroptosis 3 docs
Matched on
GPX1HK1 Bioenergetic / mito / NAD 4 docs
Matched on
HK1 hexokinase-? ?1- Energy metabolism declineconcept1
- Epigenetic and genetic interplayconcept1
- Lifestyle and behavioral factorsconcept1
- Multifactorial etiologyconcept1
LHX6 Reelin, synapse & ECM–PNN 2 docs
Matched on
LHX6LPCAT4 Lipid, sterol & membrane 2 docs
Matched on
LPCAT4MAG Myelin & axon inhibition 3 docs
Matched on
myelin[- ]associated glycoproteinNAPRT Bioenergetic / mito / NAD 4 docs
Matched on
NAPRTNOD2 Microglia & innate immunity 4 docs
Matched on
NOD2PLIN2 (perilipin-2) Lipid, sterol & membrane 4 docs
Matched on
PLIN2 perilipin-?2PROS1 Microglia & innate immunity 2 docs
Matched on
PROS1PTEN Kinase & growth-factor signalling 4 docs
Matched on
PTEN- Ari Rappoport's Lipid-Raft Theory of Plasticity, Revisitedpaper1
- Autophagic Failure as the Convergent Endpoint in Alzheimer's, Parkinson's, ALS and Huntington'spaper1
- Autophagy-Lysosomal Choke Points and Bistable Decline in Neurodegenerationpaper1
- Lysosomal Acidification Failure as the Convergent Lesion of Neurodegenerationpaper1
RECK Reelin, synapse & ECM–PNN 2 docs
Matched on
RECKRILPL1 Autophagy / lysosome / clearance 2 docs
Matched on
RILPL1SHH Kinase & growth-factor signalling 3 docs
Matched on
sonic hedgehog ShhSLC6A3 (DAT) Neuromodulator / circadian / kynurenine 1 doc
Matched on
SLC6A3 DATSREBF2 (SREBP-2) Lipid, sterol & membrane 3 docs
Matched on
SREBF2 SREBP-?2SUMF1 Autophagy / lysosome / clearance 2 docs
Matched on
SUMF1TAX1BP1 Autophagy / lysosome / clearance 4 docs
Matched on
TAX1BP1TBC1D24 Neurodegeneration overlap 2 docs
TGFBR1 Kinase & growth-factor signalling 3 docs
Matched on
TGFBR1TIMP2 Reelin, synapse & ECM–PNN 3 docs
Matched on
TIMP-?2TLR6 Microglia & innate immunity 2 docs
Matched on
TLR6TRIM44 Autophagy / lysosome / clearance 2 docs
Matched on
TRIM44ACE2 Vascular / BBB 2 docs
Matched on
ACE2ATAD1 (Thorase) Bioenergetic / mito / NAD 2 docs
Matched on
ATAD1 ThoraseATF3 Cell death & ER stress 3 docs
Matched on
ATF3ATG16L1 Autophagy / lysosome / clearance 3 docs
Matched on
ATG16L1ATP8B4 GWAS / LOAD risk 2 docs
Matched on
ATP8B4B2M Microglia & innate immunity 2 docs
Matched on
B2M microglobulinCAST (calpastatin) Reelin, synapse & ECM–PNN 2 docs
Matched on
calpastatinCD44 Microglia & innate immunity 2 docs
Matched on
CD44CDKN2D (p19INK4d) Epigenetic & senescence 2 docs
Matched on
CDKN2D p19INK4dCHAC1 Oxidative stress & ferroptosis 3 docs
Matched on
CHAC1CTSS (cathepsin S) Autophagy / lysosome / clearance 1 doc
Matched on
CTSS cathepsin SCXCL1 Microglia & innate immunity 3 docs
Matched on
CXCL1CXCR4 Microglia & innate immunity 2 docs
Matched on
CXCR4FUNDC1 Bioenergetic / mito / NAD 3 docs
Matched on
FUNDC1GLUL (glutamine synthetase) Astrocyte & glial markers 3 docs
Matched on
GLUL glutamine synthetaseHLA-DRB1 GWAS / LOAD risk 2 docs
Matched on
HLA-DRB1 HLA-DRB5 HLA-DRHSPA5 (BiP/GRP78) Cell death & ER stress 1 doc
ITGAM Microglia & innate immunity 2 docs
Matched on
ITGAMLDHA Bioenergetic / mito / NAD 3 docs
Matched on
LDHA lactate dehydrogenaseMIF Microglia & innate immunity 3 docs
Matched on
MIF macrophage migration inhibitory factorOften named withCD74
MTNR1A/B Neuromodulator / circadian / kynurenine 1 doc
Matched on
MTNR1A MTNR1B melatonin receptorNR3C1 (GR) Epigenetic & senescence 3 docs
Matched on
NR3C1 glucocorticoid receptorNRF1 (nuclear respiratory factor 1) Bioenergetic / mito / NAD 2 docs
Matched on
NRF1OMA1 Bioenergetic / mito / NAD 2 docs
Matched on
OMA1OXR1 Oxidative stress & ferroptosis 2 docs
P2RY13 Microglia & innate immunity 2 docs
Matched on
P2RY13 P2Y13RCAN1 Down-syndrome chr21 1 doc
Matched on
RCAN1 DSCR1SAMHD1 Microglia & innate immunity 2 docs
Matched on
SAMHD1SLC11A2 (DMT1) Oxidative stress & ferroptosis 2 docs
Matched on
SLC11A2 DMT1- Phase IIpaper2
- Iron Chelation and GPX4 Stabilizationpaper1
SLC19A1 Trophic / exercise / resilience 2 docs
Matched on
SLC19A1SOX2 Epigenetic & senescence 2 docs
TLR9 Microglia & innate immunity 2 docs
Matched on
TLR9TPH1 Neuromodulator / circadian / kynurenine 3 docs
WDR41 Autophagy / lysosome / clearance 3 docs
YAP1 Kinase & growth-factor signalling 2 docs
Matched on
YAP1 YAPADRA2A Neuromodulator / circadian / kynurenine 2 docs
Matched on
ADRA2A alpha-?2[- ]adrenergicATF6 Cell death & ER stress 2 docs
Matched on
ATF6ATG9A Autophagy / lysosome / clearance 2 docs
Matched on
ATG9A?BCL2L1 (Bcl-xL) Cell death & ER stress 2 docs
Matched on
BCL2L1 Bcl-?xL- Cellular Senescenceconcept1
- The Cell Biology of the Word 'Ageing'paper1
BHMT Trophic / exercise / resilience 1 doc
Matched on
BHMTCASP9 Cell death & ER stress 2 docs
Matched on
CASP9 caspase-?9CCR2 Microglia & innate immunity 2 docs
Matched on
CCR2CLIC4 Microglia & innate immunity 1 doc
Matched on
CLIC4CST3 (cystatin C) Amyloid & Tau core 2 docs
Matched on
CST3 cystatin CCTSL (cathepsin L) Autophagy / lysosome / clearance 2 docs
Matched on
CTSL cathepsin LCYP46A1 Lipid, sterol & membrane 2 docs
Matched on
CYP46A1 24S-?hydroxylaseFOXO3 Trophic / exercise / resilience 2 docs
GCLM Oxidative stress & ferroptosis 1 doc
GGA2 Autophagy / lysosome / clearance 1 doc
Matched on
GGA2GHRL (ghrelin) Neuromodulator / circadian / kynurenine 1 doc
Matched on
GHRL ghrelinHMGCR Lipid, sterol & membrane 2 docs
Matched on
HMGCR HMG-?CoA reductaseIFITM3 Microglia & innate immunity 1 doc
Matched on
IFITM3KYNU Neuromodulator / circadian / kynurenine 1 doc
Matched on
KYNULRP2 (megalin) Vascular / BBB 1 doc
Matched on
LRP2 megalin- The Brain's Border Gatepaper2
NR1H3 (LXRα) Lipid, sterol & membrane 2 docs
Matched on
NR1H3 LXROMG (OMgp) Myelin & axon inhibition 1 doc
Matched on
OMgpPIN1 Amyloid & Tau core 2 docs
Matched on
Pin1RIN3 GWAS / LOAD risk 2 docs
Matched on
RIN3RTN4 (Nogo-A) Myelin & axon inhibition 1 doc
Matched on
RTN4 Nogo-?A Nogo(?! ?receptor)SMAD4 Kinase & growth-factor signalling 2 docs
Matched on
SMAD4WWTR1 (TAZ) Kinase & growth-factor signalling 1 doc
Matched on
WWTR1 TAZATG13 Autophagy / lysosome / clearance 1 doc
Matched on
ATG13C3AR1 Microglia & innate immunity 1 doc
Matched on
C3aR C3AR1CYBB (NOX2) Microglia & innate immunity 1 doc
Matched on
CYBB NOX2ERN1 (IRE1) Cell death & ER stress 1 doc
Matched on
ERN1 IRE1MTR (methionine synthase) Trophic / exercise / resilience 1 doc
Matched on
methionine synthaseNMNAT1 Bioenergetic / mito / NAD 1 doc
Matched on
NMNAT1NQO1 Oxidative stress & ferroptosis 1 doc
Matched on
NQO1PAK1 Reelin, synapse & ECM–PNN 1 doc
Matched on
PAK1PCSK9 Lipid, sterol & membrane 1 doc
Matched on
PCSK9PLA2G4A (cPLA2) Microglia & innate immunity 1 doc
Matched on
PLA2G4A cPLA2RB1CC1 (FIP200) Autophagy / lysosome / clearance 1 doc
Matched on
RB1CC1 FIP200SERPINA3 Amyloid & Tau core 1 doc
SERPINE1 (PAI-1) Vascular / BBB 1 doc
Matched on
SERPINE1 PAI-?1SHANK3 Reelin, synapse & ECM–PNN 1 doc
Matched on
SHANK3SIRT2 Bioenergetic / mito / NAD 1 doc
Matched on
SIRT2SLC6A2 (NET) Neuromodulator / circadian / kynurenine 1 doc
Matched on
SLC6A2 norepinephrine transporterSPOCK3 (testican-3) Reelin, synapse & ECM–PNN 1 doc
SSH2 Reelin, synapse & ECM–PNN 1 doc
Matched on
SSH2- The Load-Bearing Neuronpaper1
No genes match that filter.
Method
Counts come from a case-insensitive, word-bounded text scan of each published page — the 148 papers rendered in full plus the concept, node and stage pages. The 53 PDF-only papers carry no text on the site and are not scanned. Each gene matches its symbol and its curated aliases (RELN also counts reelin; APOE counts ApoE4 and apolipoprotein E). A sentence naming two spellings counts twice. The entrant and external-scientist dossiers are withheld from this edition and are not scanned, so these tallies run lower than the full corpus.