Proteostasis Collapse

Proteostasis Collapse enters the Adult Cognitive Disease corpus through the work of Stephen Dominy (submission 74), and is indexed here as one of the concepts that submission puts to work.

The argument it belongs to

Stephen Dominy's submission is summarised in this corpus as:

The periodontal keystone pathogen P. gingivalis is the specific environmental trigger for sporadic Alzheimer's disease, with its gingipain proteases (RgpB and Kgp) serving as direct molecular agents that sabotage the neuronal autophagy-lysosomal system. Gingipains inhibit v-ATPase, proteolytically cleave VAMP8 to block autophagosome-lysosome fusion, and suppress TFEB-mediated lysosomal biogenesis.

Where it sits

The submission scores against the framework's convergence nodes as: endosomal nexus 9 · compensatory paradigm 6 · neuroimmune interface 3 · cytoskeletal collapse 2 · ApoE4 hub 1.

Its declared subject matter: infectious-hypothesis, P-gingivalis, gingipains, periodontitis, lysosomal-dysfunction, autophagy-block, SNARE-complex, oral-microbiome, antimicrobial-peptide, PANTHOS.

Named by the same submission

5 other concepts enter the corpus through the same paper, so they cover adjacent ground: Autophagy · Gut Brain Axis · Innate Immunity · Lysosomal Dysfunction · Microbial Pathogenesis.

Assembled from the corpus rather than written: the summary is quoted from the submission that named it; the node scores are read from its dossier. It has not yet been expanded into an article.