SORL1 Lysosomal Function

Sorl1 Lysosomal Function enters the Adult Cognitive Disease corpus through the work of Beth Stevens (submission 158), and is indexed here as one of the concepts that submission puts to work.

The argument it belongs to

Beth Stevens's submission is summarised in this corpus as:

Beth Stevens's laboratory is the primary experimental source for complement-mediated microglial synaptic pruning in Alzheimer's disease: the classical cascade C1q -> C3 -> CR3-mediated microglial phagocytosis, a developmental synapse-elimination program aberrantly re-activated in the aging and AD brain to eliminate synapses that should be spared (Hong et al. 2016 showed complement knockout rescues synapse loss independent of amyloid). Her program extends to Bmal1-circadian regulation of border-associated macrophages and to SORL1 in microglial lysosomal function. NOTE: submission #158's paper PDF is missing from the corpus (the stored file is the OFP rules document); the 'dance battle between human and germ' hypothesis previously recorded here belongs to submission #168 (Amy Nelson). This entry describes Stevens's documented laboratory program, not a verified OFP submission.

Where it sits

The submission scores against the framework's convergence nodes as: neuroimmune interface 9 · compensatory paradigm 6 · ApoE4 hub 5 · endosomal nexus 4 · transcriptional / epigenetic 3 · cytoskeletal collapse 2.

Its declared subject matter: complement-pruning, C1q, C3, CR3, microglial-synapse-elimination, border-associated-macrophages, Bmal1-circadian, SORL1-microglial-lysosome, homeostatic-microglial-collapse, ANX005, pegcetacoplan, submission-pdf-missing.

Named by the same submission

7 other concepts enter the corpus through the same paper, so they cover adjacent ground: Antimicrobial hypothesis of amyloid · BBB breakdown cascade · Human-germ interaction model · Neurovascular unit as disease origin · Cellular Senescence · Circadian Immune Regulation · Neuroimmune Surveillance.

Assembled from the corpus rather than written: the summary is quoted from the submission that named it; the node scores are read from its dossier. It has not yet been expanded into an article.