WikiAdultCognitiveDisease.com

Stage 1: Molecular Initiation

Years -30 to -15

Timeframe: Years -30 to -15 before clinical onset

Primary insult accumulates (lipid peroxidation, excitatory insufficiency, or Abeta monomer loss). No histopathology yet. This is the longest preclinical phase, during which the initial molecular damage silently builds.

Key Events

  • Primary insult begins accumulating
  • No detectable histopathology
  • No clinical symptoms
  • Multiple potential initiating mechanisms may operate in parallel

Next Stage

Endosomal Dysregulation

Source: kb/wiki/temporal-stages/stage-1-molecular-initiation.md