Transcriptional-Epigenetic Dysregulation Node

Progressive gene expression changes that lock in the pathological state, making neurodegeneration self-sustaining.

Converging Mechanisms

• CREB-mediated transcriptional changes from NMDA hypofunction (Moosmann)
• HDAC6 upregulation and chromatin remodeling (Rappoport)
• miRNA dysregulation (miR-134, let-7) affecting spine stability
• LINE-1 transposable element reactivation
• Progressive gene expression changes that lock in pathological state

Key Concept

Once transcriptional programs shift, the disease becomes self-reinforcing at the epigenetic level, independent of the original triggers.

Related Researchers

To be populated after CSC grading.

See Also

• Compensatory Paradigm Nexus
• Cytoskeletal Collapse Node