The Homeostatic–Matrix–Synaptic (HMS) Collapse Model

Integrates twenty-one research programs across the Synaptic, Microglial, and PNN theses into a single trilayered framework in which TGF-β/SMAD collapse simultaneously unleashes post-homeostatic microglia, licenses matrix degradation, and reactivates developmental synaptic pruning — with the parvalbumin-positive interneuron and its perineuronal net as the shared anatomical pivot.