WikiAdultCognitiveDisease.com
87 companion films

Videos

Most papers in the corpus have a short film on the Adult Cognitive Disease channel. They are laid out here the way the wiki is — along the disease's own fifty-year timeline. Every thumbnail opens the film; the title opens the paper.

Watch the full channel on YouTube →

Start Here 6

The 50-Year Front — The Temporal Architecture of Alzheimer's
The Master Theory: Why All Roads Lead to the Same Failure
One Mechanism, Many Diseases (AD, PD, ALS, HD)

The Record 2

Fischer's Sidelining: A Biographical–Intellectual History
What If We'd Listened to Fischer?

Groundwork 16

The Vascular Phasing (PhD Thesis)
Vascular Pathology as a Substrate Across Phases
The Genetic Architecture of Neurodegeneration (PhD)
Where the Lipid Disorder and the Energy Disorder Are One
The Lipid That Kills Neurons and Spares Tumours
The Genes That Protect — Phenocopy the Fortunate
Down Syndrome as the Disease Run in Fast-Forward
The Cell Biology of the Word 'Ageing'
The Reversible Layer — Erosion of the Cell's Memory
Why Exercise Prevents but Does Not Cure
When the Brain's Trophic Subsidy Is Withdrawn
The Glial Consortium and the Timeline of Collapse
Huang: Aβ as a Two-Faced Molecule
Khachaturian: The Calcium Hypothesis & Systems Failure
Khachaturian: Calcium × Autolysosomal Acidification

Phase I — The Silent Brainstem Erosion 12

The Tryptophan Partition (PhD Thesis)
NAD⁺ Restoration and CD38 Inhibition
Norepinephrine as a Two-Armed Pincer on Tau
The Enzyme That Cuts the Protective Lattice
The Failing Clock That Stops Defending the Brainstem
Sleep as the Shared Off-Line State of Every Collapse Axis
The Coerulean Interface — The Brainstem Origin of Alzheimer's
Anatomy of a Neurodegenerative Conduit — The Vagal Interface
The Bioenergetic Thesis (Downloadable PDF)

Phase II — The Hippocampal Bridgehead 17

The Locus Coeruleus as Phase Bridge
The Innate-Immune Sensor That Converts the Disease
When the Inflammasome Turns on the Matrix
One Sensor, Two Collapses — Which Arm Matters More?
Everything That Corrupts the Brain's Gardener, Ranked
The Immune Cells That Keep the Peace — Until They Don't
The Brain's Border Gate: Source, Sieve, and Sentinel
The Matrix as the Seventh Axis of Collapse
Iron Chelation and GPX4 Stabilization
Fischer's Matrix: The Founder Axis Rediscovered
Perineuronal Nets, Microglial Neuroinflammation, and Alzheimer's
Homeostatic Microglial Collapse
The Peripheral Arm of Homeostatic Collapse
Bioenergetic Collapse

Phase III — The Synaptic Disintegration 11

The Synaptic Thesis (Downloadable PDF)
The Brain's Architect and the Brake It Puts on Tau
One Sugar Lattice, Three Jobs
The Three-Body Clasp at the Membrane
Rappoport: The Lipid-Raft Hypothesis and Adaptive Response Plasticity
Moosmann & Sohre: NMDA Failure as the Root Cause
Ramsden: When Oxidative Damage Reaches the Synapse
Small: The Endosomal Traffic Jam
Gouras: Intraneuronal Aβ and the Inside-Out Paradigm
Margolis: How Synapses Are Dismantled from Within
Shatz & Brott: Complement-Mediated Synaptic Pruning

The Convergence 9

How the Brain Washes Itself — and Why That Fails
Viral Reactivation Across Three Phases (PhD)
The Clearance Collapse — One Machinery, Three Failures
How Plaques Actually Form: A Timeline
How Free Radicals Disable the Recycling System
How Viruses Sabotage Brain Cleanup
Can Vaccines Protect Against Dementia?
Many Causes, One Bottleneck
How to Fix the Broken Recycling System

The Synthesis 12

The Spectrum of Collapse
The Biomarker Cascade (PhD Thesis)
The Whole Architecture, Graded by Evidence
The Ketamine Paradox
The Homeostatic–Matrix–Synaptic (HMS) Collapse Model
Terminal Collapse: Naming the Death

The Frontier 2

Vaccines That May Prevent Dementia
The Therapeutic Landscape of Collapse