Cytoskeletal Collapse Node
Actin and microtubule cytoskeleton attacked by multiple mechanisms, leading to dendritic spine loss and synaptic failure.
Converging Mechanisms
- LIMK1 hyperactivation and cofilin inactivation (Ramsden: GSK3beta cascade)
- Ephexin5-RhoA-ROCK-mediated actin-myosin contraction (Margolis)
- Competitive synaptic plasticity dysregulation (Huang)
- Complement-mediated dendritic spine destruction (Shatz/Brott)
Key Molecules
GSK3beta, LIMK1, cofilin, Ephexin5, RhoA, ROCK, PSD95
Related Researchers
To be populated after CSC grading.
See Also
Papers converging on this axis
8
Convergent Synaptic Collapse (CSC) — Grading Reference
1 concept · 4 genes shared
The Matrix of Collapse
1 concept · 3 genes shared
The Clearance Collapse
2 concepts shared
The Architect's Handshake
2 genes shared
Margolis
1 gene shared
The Architect's Reprieve
1 gene shared
The Architect's Scaffold
1 gene shared
The Architecture of Resistance
1 gene shared
Concepts on this axis
8Source:
kb/wiki/convergence-nodes/cytoskeletal-collapse.md