Stage 3: Cytoskeletal Perturbation

Timeframe: Years -5 to 0 (clinical onset)

GSK3beta becomes hyperactive, dendritic spines begin collapsing. First cognitive changes appear. Transition to Mild Cognitive Impairment (MCI).

Key Events

• GSK3beta hyperactivation
• Dendritic spine collapse begins
• First detectable cognitive changes
• Clinical transition to MCI

Related Nodes

• Cytoskeletal Collapse Node
• Endosomal Nexus

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Endosomal Dysregulation | Neuroimmune Activation