Stage 5: Network Disintegration
Years 5 to 15
Timeframe: Years 5 to 15 after clinical onset
Widespread neuronal death, tau tangles, plaques. Severe dementia. All convergence nodes are now maximally active and synergistically destructive.
Key Events
- Widespread neuronal death
- Tau tangles and amyloid plaques fully established
- Severe dementia
- All convergence nodes maximally active
Related Nodes
- Endosomal Nexus
- Cytoskeletal Collapse Node
- Neuroimmune Interface
- Transcriptional-Epigenetic Dysregulation Node
Previous Stage
Source:
kb/wiki/temporal-stages/stage-5-network-disintegration.md