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PDF paper · Comprehensive

One Mechanism, Many Diseases (AD, PD, ALS, HD)

Unified systems analysis of autophagic failure as the convergent endpoint in AD, PD, ALS, FTD, and Huntington's Disease.

Earlier framing

Written when the corpus framed Alzheimer's as a single convergent collapse. The mechanism it describes still holds — but as one component of the three-phase model that superseded the singular framing.

The current model → The Temporal Architecture of Collapse

This paper is published as a typeset PDF — the full text lives there.

Read the paper (PDF) → Slide deck