Adult Neurogenesis

Adult Neurogenesis enters the Adult Cognitive Disease corpus through the work of Carlo Abbate (submission 76), and is indexed here as one of the concepts that submission puts to work.

The argument it belongs to

Carlo Abbate's submission is summarised in this corpus as:

Alzheimer's disease originates in neural stem cells within adult neurogenesis niches. Factors inherent to neurogenesis and migration trigger pathological tau hyperphosphorylation, amplified by amyloid pathology.

The source paper puts the concept to work directly:

Therefore, the current model of tau pathogenesis based on adult neurogenesis and migration in a special case of brain injury fits well for explaining the peculiar sites of pathological tau deposition in CTE.

Where it sits

The submission scores against the framework's convergence nodes as: neuroimmune interface 6 · endosomal nexus 4 · cytoskeletal collapse 3 · compensatory paradigm 2 · ApoE4 hub 1 · transcriptional / epigenetic 1.

Its declared subject matter: adult-neurogenesis, neural-stem-cells, tau-propagation, neuroinflammation, reactive-neurogenesis, neuroblast-migration, Braak-staging, LOAD, EOAD, PANTHOS, plaque-cognition-dissociation, diagnostic-criteria-critique.

Use in the corpus

Referred to by 7 documents in the research corpus, including research/abbate-evaluation/Abbate_Evaluation_Paper.md, research/bdnf-subsidy/PhD_Thesis_Withdrawn_Subsidy.md, research/collapse-trilogy/bioenergetic/PhD_Thesis_Tryptophan_Partition_Node.md, research/collapse-trilogy/convergent-synaptic/Adult_Neurogenesis_Paper.md.

Named by the same submission

7 other concepts enter the corpus through the same paper, so they cover adjacent ground: Amyloid Clinical Disconnect · Autophagic Collapse · Cellular Vectors · Neuroinflammation · Synaptic Pathology · Syndromic Complexity · Tau Propagation.

Related

Synaptic Plasticity · cognitive resilience · Convergent Synaptic Collapse · Perineuronal Nets

Assembled from the corpus rather than written: the summary is quoted from the submission that named it; the passage is quoted from that submission's source paper; the node scores are read from its dossier; the reference count is measured across the research corpus. It has not yet been expanded into an article.