Adult Cognitive DiseaseThe research corpus Monographs
the evidence base

Every source this corpus cites

4,029 distinct works behind 165 papers. 3,257 carry a DOI or PubMed ID, each resolved against PubMed or Crossref and checked against the reference printed beside it. Search it, or start from what the corpus leans on hardest.

The backbone

The works cited by a dozen or more papers here. These are the load-bearing sources: if one of them were overturned, a great deal above it would move.

  1. 40Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brainCrapser · EBioMedicine · 2020
  2. 28Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaquesLee JH · Nature Neuroscience · 2022
  3. 27Complement and microglia mediate early synapse loss in Alzheimer mouse modelsHong · Science · 2016
  4. 27A unique microglia type associated with restricting development of Alzheimer's diseaseKeren-Shaul · Cell · 2017
  5. 26Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case reportArboleda-Velasquez JF · Nature Medicine · 2019
  6. 25The pathological process underlying Alzheimer's disease in individuals under thirtyBraak · Acta Neuropathologica · 2011
  7. 25Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous manLopera F · Nature Medicine · 2023
  8. 24Identification of a unique TGF-β-dependent molecular and functional signature in microgliaButovsky O · Nature Neuroscience · 2014
  9. 23Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 yearsBraak H · Journal of Neuropathology and Experimental Neurology · 2011
  10. 21Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brainMarschallinger J · Nature Neuroscience · 2020
  11. 21Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's diseaseMorawski M · Neuroscience · 2010
  12. 21The classical complement cascade mediates CNS synapse eliminationStevens · Cell · 2007
  13. 21Lecanemab in early Alzheimer's diseasevan Dyck CH · New England Journal of Medicine · 2023
  14. 20C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer's disease and mediates synapse pruningBrott · Proceedings of the National Academy of Sciences · 2025
  15. 20Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seedsHolmes BB · Proceedings of the National Academy of Sciences USA · 2013
  16. 20Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trialSims JR · JAMA · 2023
  17. 20Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairmentTerry · Annals of Neurology · 1991
  18. 17Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrineHeneka MT · Proceedings of the National Academy of Sciences USA · 2010
  19. 17NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 miceHeneka · Nature · 2013
  20. 16N-Sulfated Heparan Sulfate Promotes Reelin Signaling as a Co-receptorPan L · Journal of the American Chemical Society · 2025
  21. 15Neuropathological stageing of Alzheimer-related changesBraak H · Acta Neuropathologica · 1991
  22. 15Resilience to Alzheimer's disease associates with alterations in perineuronal netsde Vries · Alzheimer's & Dementia · 2025
  23. 14Perineuronal nets protect fast-spiking interneurons against oxidative stressCabungcal · Proceedings of the National Academy of Sciences · 2013
  24. 14Resilience to Alzheimer's disease associates with alterations in perineuronal netsde Vries LE · Alzheimer's & Dementia · 2024

Important noticeThis is a research platform, not a medical site. Nothing here is medical advice, a diagnosis, or a treatment recommendation, and none of it has been reviewed by a regulator. The drugs, doses and trials discussed are research literature, not prescriptions. If dementia affects you or someone you care about, speak to a doctor.

Compiled from the knowledge base and the research corpus under the Organic Network Synthesis methodology · the research corpus of Adult Cognitive Disease · the seven monographs are here. 2026.

827 interlinked articles · 120 papers in full · 53 as typeset PDFs · 635 concepts · 7 convergence nodes · 5 temporal stages.

Discussion

Corrections and disagreements are welcome here, and citation corrections most of all. Posting needs a GitHub account. Please read Taking Part first — in particular, nothing here is medical advice.