Adult Cognitive DiseaseThe research corpus Monographs
the evidence base

Every source this corpus cites

5,199 distinct works behind 190 papers. 4,351 carry a DOI or PubMed ID, each resolved against PubMed or Crossref and checked against the reference printed beside it. Search it, or start from what the corpus leans on hardest.

The backbone

The works cited by a dozen or more papers here. These are the load-bearing sources: if one of them were overturned, a great deal above it would move.

  1. 44Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brainCrapser · EBioMedicine · 2020
  2. 37Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaquesLee JH · Nature Neuroscience · 2022
  3. 31A unique microglia type associated with restricting development of Alzheimer's diseaseKeren-Shaul · Cell · 2017
  4. 30Complement and microglia mediate early synapse loss in Alzheimer mouse modelsHong · Science · 2016
  5. 29Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case reportArboleda-Velasquez JF · Nature Medicine · 2019
  6. 29Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairmentTerry · Annals of Neurology · 1991
  7. 28Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 yearsBraak H · Journal of Neuropathology and Experimental Neurology · 2011
  8. 28The pathological process underlying Alzheimer's disease in individuals under thirtyBraak · Acta Neuropathologica · 2011
  9. 28Resilience to autosomal dominant Alzheimer's disease in a Reelin-COLBOS heterozygous manLopera F · Nature Medicine · 2023
  10. 26Identification of a unique TGF-β-dependent molecular and functional signature in microgliaButovsky O · Nature Neuroscience · 2014
  11. 24Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's diseaseMorawski M · Neuroscience · 2010
  12. 23C4d, a high-affinity LilrB2 ligand, is elevated in Alzheimer's disease and mediates synapse pruningBrott · Proceedings of the National Academy of Sciences · 2025
  13. 23Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seedsHolmes BB · Proceedings of the National Academy of Sciences USA · 2013
  14. 22Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brainMarschallinger J · Nature Neuroscience · 2020
  15. 22Donanemab in early symptomatic Alzheimer disease: the TRAILBLAZER-ALZ 2 randomized clinical trialSims JR · JAMA · 2023
  16. 22Lecanemab in early Alzheimer's diseasevan Dyck CH · New England Journal of Medicine · 2023
  17. 21The classical complement cascade mediates CNS synapse eliminationStevens · Cell · 2007
  18. 20Neuropathological stageing of Alzheimer-related changesBraak H · Acta Neuropathologica · 1991
  19. 19NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 miceHeneka · Nature · 2013
  20. 19Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylationHiesberger T · Neuron · 1999
  21. 19N-Sulfated Heparan Sulfate Promotes Reelin Signaling as a Co-receptorPan L · Journal of the American Chemical Society · 2025
  22. 18Resilience to Alzheimer's disease associates with alterations in perineuronal netsde Vries · Alzheimer's & Dementia · 2025
  23. 17Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrineHeneka MT · Proceedings of the National Academy of Sciences USA · 2010
  24. 16Perineuronal nets protect fast-spiking interneurons against oxidative stressCabungcal · Proceedings of the National Academy of Sciences · 2013

Important noticeThis is a research platform, not a medical site. Nothing here is medical advice, a diagnosis, or a treatment recommendation, and none of it has been reviewed by a regulator. The drugs, doses and trials discussed are research literature, not prescriptions. If dementia affects you or someone you care about, speak to a doctor.

Compiled from the knowledge base and the research corpus under the Organic Network Synthesis methodology · the research corpus of Adult Cognitive Disease · the seven monographs are here. 2026.

854 interlinked articles · 148 papers in full · 53 as typeset PDFs · 635 concepts · 7 convergence nodes · 5 temporal stages.

Discussion

Corrections and disagreements are welcome here, and citation corrections most of all. Posting needs a GitHub account. Please read Taking Part first — in particular, nothing here is medical advice.