Adult Cognitive DiseaseThe research corpus Monographs

Neuronal Excitability

Neuronal Excitability enters the Adult Cognitive Disease corpus through the work of Zaven Khachaturian (submission 128), and is indexed here as one of the concepts that submission puts to work.

The argument it belongs to

Zaven Khachaturian's submission is summarised in this corpus as:

The Calcium System Theory of Alzheimer's Disease (CAST-AD) reframes AD as a progressive degradation of neuronal performance driven by chronic failure of intracellular calcium homeostatic control mechanisms. The neuron is modeled as a 'system-process control unit' where calcium dysregulation serves as the upstream control parameter for a nonlinear phase transition from functional to degenerative attractor states.

Where it sits

The submission scores against the framework's convergence nodes as: endosomal nexus 6 · compensatory paradigm 2 · ApoE4 hub 2 · cytoskeletal collapse 1 · neuroimmune interface 1.

Its declared subject matter: calcium-hypothesis, systems-theory, cybernetics, control-theory, nonlinearity, phase-transition, multiscale-modeling, calcium-homeostasis, CAST-AD, neuron-performance.

Use in the corpus

Referred to by 4 documents in the research corpus, including research/collapse-trilogy/convergent-synaptic/ONS_SynapticCollapse_Thesis.md, research/down-syndrome/PhD_Thesis_Compressed_Architecture.md, research/gouras-synaptic-collapse/The_Same_Machine.md, research/ofp-entry/ONS_OFP_Entry.md.

Named by the same submission

4 other concepts enter the corpus through the same paper, so they cover adjacent ground: Bioenergetics · Calcium Homeostasis · Lysosomal Dysfunction · Systems Biology.

Autophagy · cognitive resilience · Oskar Fischer Founder · Cellular Senescence · Ferroptosis · Intracellular Amyloid

Assembled from the corpus rather than written: the summary is quoted from the submission that named it; the node scores are read from its dossier; the reference count is measured across the research corpus. It has not yet been expanded into an article.

Last reviewed 15 August 2026.

Important noticeThis is a research platform, not a medical site. Nothing here is medical advice, a diagnosis, or a treatment recommendation, and none of it has been reviewed by a regulator. The drugs, doses and trials discussed are research literature, not prescriptions. If dementia affects you or someone you care about, speak to a doctor.

Compiled from the knowledge base and the research corpus under the Organic Network Synthesis methodology · the research corpus of Adult Cognitive Disease · the seven monographs are here. 2026.

827 interlinked articles · 120 papers in full · 53 as typeset PDFs · 635 concepts · 7 convergence nodes · 5 temporal stages.

Discussion

Corrections and disagreements are welcome here, and citation corrections most of all. Posting needs a GitHub account. Please read Taking Part first — in particular, nothing here is medical advice.