Psychological origins of neurodegeneration

Psychological origins of neurodegeneration enters the Adult Cognitive Disease corpus through the work of Dana Varadiova (submission 112), and is indexed here as one of the concepts that submission puts to work.

The argument it belongs to

Dana Varadiova's submission is summarised in this corpus as:

AD originates from dysfunction of the Self/Default Mode Network (DMN), driven by failed sense-making processes rooted in early childhood experiences. Psychological conflicts and chronic anxiety from impaired self-awareness lead to adrenergic dysfunction, norepinephrine upregulation, and eventual neurodegeneration in circuits responsible for declarative memory and self-reflection.

Where it sits

The submission scores against the framework's convergence nodes as: compensatory paradigm 3 · neuroimmune interface 1 · transcriptional / epigenetic 1.

Its declared subject matter: default-mode-network, psychology, self-awareness, sense-making, adrenergic-dysfunction, childhood-experience, anxiety, norepinephrine.

Named by the same submission

3 other concepts enter the corpus through the same paper, so they cover adjacent ground: Childhood experience shaping AD vulnerability · Self-DMN dysfunction hypothesis · Sense-making failure and cellular conflict.

Assembled from the corpus rather than written: the summary is quoted from the submission that named it; the node scores are read from its dossier. It has not yet been expanded into an article.