7 articles

Convergence Nodes

The cross-researcher axes where independent hypotheses converge on shared mechanism.

The early endosome — and the endosomal–lysosomal–autophagy network it opens onto — as the critical anatomical compartment where multiple ind

Actin and microtubule cytoskeleton attacked by multiple mechanisms, leading to dendritic spine loss and synaptic failure.

Hallmark pathological features (amyloid, tau) reinterpreted as initially protective responses that become pathologically reinforced over tim

Microglial-complement pruning cascade that accelerates synaptic loss through immune-mediated destruction.

A single polymorphism activating 8+ pathogenic mechanisms simultaneously — both loss-of-function AND gain-of-function.

Progressive gene expression changes that lock in the pathological state, making neurodegeneration self-sustaining.

Systemic insulin resistance, mitochondrial decline, and brain bioenergetic failure converge on the same PI3K/AKT/mTOR and TGF-β/SMAD signali