Stage 2: Endosomal Dysregulation
Years -15 to -5
Timeframe: Years -15 to -5 before clinical onset
Compensatory responses become excessive. Abeta accumulates in endosomes. Retromer dysfunction manifests. Individuals are asymptomatic but amyloid-positive on PET imaging.
Key Events
- Compensatory responses become excessive
- Abeta accumulates in endosomes
- Retromer dysfunction manifests
- Asymptomatic but amyloid-positive