Adult Cognitive DiseaseThe research corpus Monographs

Stage 3: Cytoskeletal Perturbation

Years -5 to 0

Timeframe: Years -5 to 0 (clinical onset)

GSK3beta becomes hyperactive, dendritic spines begin collapsing. First cognitive changes appear. Transition to Mild Cognitive Impairment (MCI).

Key Events

  • GSK3beta hyperactivation
  • Dendritic spine collapse begins
  • First detectable cognitive changes
  • Clinical transition to MCI

Previous / Next

Endosomal Dysregulation | Neuroimmune Activation

Last reviewed 5 April 2026.

Important noticeThis is a research platform, not a medical site. Nothing here is medical advice, a diagnosis, or a treatment recommendation, and none of it has been reviewed by a regulator. The drugs, doses and trials discussed are research literature, not prescriptions. If dementia affects you or someone you care about, speak to a doctor.

Compiled from the knowledge base and the research corpus under the Organic Network Synthesis methodology · the research corpus of Adult Cognitive Disease · the seven monographs are here. 2026.

827 interlinked articles · 120 papers in full · 53 as typeset PDFs · 635 concepts · 7 convergence nodes · 5 temporal stages.

Discussion

Corrections and disagreements are welcome here, and citation corrections most of all. Posting needs a GitHub account. Please read Taking Part first — in particular, nothing here is medical advice.